ACTIVE-SITE DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE

Design of Active-Site-Directed Irreversible Enzyme Inhibitors.

1967 • 387 citations

Puromycin. Synthetic Studies. VIII. Synthesis of 3-Amino-3-deoxy-D-ribofuranoside Derivatives. A Second Synthesis of 3-Amino-3-deoxy-D-ribose

1955 • 97 citations

POTENTIAL ANTICANCER AGENTS.¹ LXVI. NON-CLASSICAL ANTIMETABOLITES. III.² 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR OF GLUTAMIC DEHYDROGENASE

1961 • 72 citations

Puromycin. Synthetic Studies. IX. Total Synthesis

1955 • 64 citations

Potential Anticancer Agents --L. Non-Classical Antimetabolites--II. Some Factors in the Design of Exo-Alkylating Enzyme Inhibitors, partcularly of Lactic Dehydrogenase

1960 • 63 citations

Analogs of Tetrahydrofolic Acid. X.^1,2 Synthetic and Enzymic Studies on the Contribution of the p-Aminobenzoyl-L-glutamate Moiety of Pyrimidyl Analogs to Binding to Some Folic Cofactor Area Enzymes

1964 • 59 citations

Relative reversal by vitamins (rho-aminobenzoic, folic, and folinic acids) of the effects of sulfadiazine and pyrimethamine on Toxoplasma, mouse and man.

1957 • 55 citations

Analogs of tetrahydrofolic acid. XII. On the relative contribution by the 2‐amino and 4‐hydroxy groups of 2‐amino‐5‐(3‐anilinopropyl)‐6‐methyl‐4‐pyrimidinol to inhibition of folic reductase and thymidylate synthetase

1964 • 52 citations

Irreversible enzyme inhibitors. CXLIX. Tissue-specific irreversible inhibitors of dihydrofolic reductase

1969 • 44 citations

A Study of the Uptake and Degradation of Folic Acid, Citrovorum Factor, Aminopterin, and Pyrimethamine by Bacteria

1959 • 42 citations

Irreversible Enzyme Inhibitors. CV.^1,2 Differential Irreversible Inhibition of Vertebrate Dihydrofolic Reductases by Derivatives of 4,6-Diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazines Substituted with a Terminal Sulfonyl Fluoride³

1967 • 40 citations

Specific Irreversible Enzyme Inhibitors

1970 • 40 citations

Effect of Pyrimethamine on Folic Acid Metabolism in Streptococcus faecalis and Escherichia coli

1959 • 30 citations

Analogs of Tetrahydrofolic Acid VII

1963 • 24 citations

Methotrexate and folic reductase in human cancer

1966 • 20 citations

Nonclassical Antimetabolites XV.

1964 • 18 citations

Irreversible enzyme inhibitors. CLXXVII. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(phenylalkylphenyl)-s-triazines. II

1970 • 16 citations

Irreversible enzyme inhibitors. CLXXV. Irreversible inhibition of purifed dihydrofolic reductase

1970 • 13 citations

Non-classical antimetabolites. XI

1963 • 12 citations

Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-[p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido]-o-toluenesulfonyl fluoride (NSC-113423), and active-site-directed irreversible inhibitor of dihydrofolic reductase

1970 • 11 citations

Irreversible enzyme inhibitors. CLXXIII. Cure of Walker 256 ascites by reversible and irreversible inhibitors of dihydrofolic reductase derived from 1-(substituted-phenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine

1970 • 11 citations

Irreversible enzyme inhibitors. CXXXIII. Differential irreversible inhibition of dihydrofolic reductase from three strains of L1210 leukemia, liver, spleen, and intestine of the mouse

1969 • 10 citations

Irreversible enzyme inhibitors. CXIX. Active-site-directed irreversible inhibitors of dihydrofolic reductase with tissue specificity derived from 2,4,6-triaminopyrimidine with a terminal sulfonyl fluoride at the 5 position

1968 • 7 citations