Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Homocysteine and Risk of Ischemic Heart Disease and Stroke

2002 • 2,000 citations

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

2002 • 1,921 citations

Endothelial Nitric Oxide Synthase in Vascular Disease

2006 • 1,777 citations

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

2006 • 1,639 citations

Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction

2006 • 1,424 citations

Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death

2004 • 1,360 citations

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

2004 • 1,015 citations

A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes

1995 • 759 citations

Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults

2004 • 726 citations

Homocysteine Impairs the Nitric Oxide Synthase Pathway

2001 • 663 citations

Homocystinemia

1974 • 655 citations

Homocyst(e)ine, Diet, and Cardiovascular Diseases

1999 • 583 citations

Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels

2001 • 538 citations

Homocysteine and cardiovascular disease: cause or effect?

2000 • 442 citations

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials

2005 • 438 citations

Mechanisms of homocysteine-induced oxidative stress

2005 • 389 citations

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels

2006 • 352 citations

Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis

2003 • 339 citations

Will mandatory folic acid fortification prevent or promote cancer?

2004 • 336 citations

Folate Therapy and In-Stent Restenosis after Coronary Stenting

2004 • 332 citations

Improvement in Stroke Mortality in Canada and the United States, 1990 to 2002

2006 • 328 citations

Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells.

1993 • 314 citations

Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia

2003 • 308 citations

Blood Levels of Homocysteine and Increased Risks of Cardiovascular Disease

2000 • 304 citations

Predisposition to Atherosclerosis by Infections

2002 • 301 citations

Increased Superoxide Production in Coronary Arteries in Hyperhomocysteinemia

2003 • 273 citations

Vascular Outcome in Patients With Homocystinuria due to Cystathionine β-Synthase Deficiency Treated Chronically

2001 • 249 citations

Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid

1997 • 215 citations

Hyperhomocysteinemia Activates Nuclear Factor-κB in Endothelial Cells via Oxidative Stress

2003 • 181 citations

Asymmetric Dimethylarginine Produces Vascular Lesions in Endothelial Nitric Oxide Synthase–Deficient Mice

2004 • 180 citations

Homocysteine and Hemostasis: Pathogenetic Mechanisms Predisposing to Thrombosis

1996 • 166 citations

Homocysteine induces oxidative stress by uncoupling of no synthase activity through reduction of tetrahydrobiopterin

2004 • 159 citations

Long-Term Homocysteine-Lowering Treatment With Folic Acid Plus Pyridoxine Is Associated With Decreased Blood Pressure but Not With Improved Brachial Artery Endothelium-Dependent Vasodilation or Carotid Artery Stiffness

2001 • 150 citations

Secondary prevention with folic acid: effects on clinical outcomes

2003 • 146 citations

Hyperhomocystinemia Impairs Endothelial Function and eNOS Activity via PKC Activation

2005 • 146 citations

Asymmetric Dimethylarginine Predicts Major Adverse Cardiovascular Events in Patients With Advanced Peripheral Artery Disease

2006 • 142 citations

HOMOCYSTINURIA, THROMBOSIS, AND THE BLOOD-PLATELETS

1964 • 138 citations

Modification of Fibrinogen by Homocysteine Thiolactone Increases Resistance to Fibrinolysis: A Potential Mechanism of the Thrombotic Tendency in Hyperhomocysteinemia

2006 • 130 citations

Effect of thiol oxidation and thiol export from erythrocytes on determination of redox status of homocysteine and other thiols in plasma from healthy subjects and patients with cerebral infarction

1995 • 128 citations

Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C.

2000 • 125 citations

Global Improvement of Vascular Function and Redox State With Low-Dose Folic Acid

2007 • 125 citations

Homocysteine induces VCAM-1 gene expression through NF-κB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants

2007 • 120 citations

Effect of Plasma Homocysteine Concentration on Early and Late Events in Patients With Acute Coronary Syndromes

2000 • 119 citations

Redox-Sensitive Regulation of LOX-1 Gene Expression in Vascular Endothelium

2001 • 117 citations

Influence of Hyperhomocysteinemia on the Cellular Redox State – Impact on Homocysteine-Induced Endothelial Dysfunction

2003 • 116 citations

High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury

2008 • 115 citations

Classical homocystinuria: Vascular risk and its prevention

2003 • 111 citations

Glutathione Peroxidase-1 and Homocysteine for Cardiovascular Risk Prediction

2005 • 108 citations

Oxidative Stress, Antioxidant Vitamins, and Atherosclerosis

2003 • 107 citations

Elevated total plasma homocysteine, a risk factor for thrombosis. Relation to coagulation and fibrinolytic parameters

1993 • 99 citations

Elevated endothelin concentrations are associated with reduced coronary vasomotor responses in patients with chest pain and normal coronary arteriograms

1999 • 99 citations

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

2008 • 96 citations

Homocysteine impairs coronary microvascular dilator function in humans

2002 • 90 citations

A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease

2001 • 90 citations

Atherosclerosis and Oxidant Stress: The End of the Road for Antioxidant Vitamin Treatment?

2007 • 89 citations

Homocysteine induces endothelial dysfunction via inhibition of arginine transport.

2007 • 80 citations

Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12

2005 • 78 citations

HEALTH AND SOCIAL CLASS.

1965 • 76 citations

Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype

2005 • 69 citations

Coronary endothelial function in hyperhomocysteinemia: improvement after treatment with folic acid and cobalamin in patients with coronary artery disease

2002 • 67 citations

Effect of Folic Acid on Endothelial Function Following Acute Myocardial Infarction

2006 • 66 citations

Homocysteine stimulates nuclear factor κB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C

2000 • 65 citations

Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype

2005 • 54 citations

Carotid artery stiffness in patients with end-stage renal disease: no effect of long-term homocysteine-lowering therapy.

2000 • 52 citations

Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines

2006 • 45 citations

Novel Therapies Targeting Vascular Endothelium

2006 • 45 citations

Contribution of whole blood to the control of plasma asymmetrical dimethylarginine

2006 • 44 citations

Hyperhomocysteinemic Subjects Have Enhanced Expression of Lectin-Like Oxidized LDL Receptor-1 in Mononuclear Cells

2003 • 44 citations

Homocysteine stimulates nuclear factor κB activity and interleukin-6 expression in rat vascular smooth muscle cells

2006 • 41 citations

Homocyst(e)ine-Lowering Therapy Does Not Affect Plasma Asymmetrical Dimethylarginine Concentrations in Patients with Peripheral Artery Disease

2005 • 35 citations

Homocysteine and Endothelial Function in Human Studies

2005 • 34 citations

The effects of folate supplementation on some coagulation parameters and oxidative status surrogates

2002 • 33 citations

Effects of homocysteine on the levels of caveolin-1 and eNOS in caveolae of human coronary artery endothelial cells

2006 • 27 citations

Homocysteine Modulates the CD40/CD40L System

2007 • 26 citations

Homocysteine: a risk factor for coronary artery disease?

2005 • 20 citations

Homocysteine decreases endothelin-1 expression by interfering with the AP-1 signaling pathway

2002 • 20 citations

Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by interfering with MAPK kinase pathway

2005 • 18 citations

Methionine-Loading Rapidly Impairs Endothelial Function, by Mechanisms Independent of Endothelin-1: Evidence for an Association of Fasting Total Homocysteine with Plasma Endothelin-1 Levels

2008 • 16 citations

Homocysteine predicts adverse clinical outcomes in unstable angina and non-ST elevation myocardial infarction: implications from the folate intervention in non-ST elevation myocardial infarction and unstable angina study

2008 • 13 citations

Plasma Homocysteine Levels and Late Outcome in Patients with Unstable Angina

2007 • 12 citations

[The pathogenic mechanism of homocysteine -induced endothelial nitric oxide synthase dysfunction and the antagonistic effects by folic acid].

2007 • 10 citations

[Non-invasive assessment of endothelial function].

1998 • 3 citations