Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1982 • 1,160 citations

Suitability of urethane anesthesia for physiopharmacological investigations in various systems Part 1: General considerations

1986 • 389 citations

Minireview: Multiple MU opiate receptors

1986 • 348 citations

Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.

1982 • 296 citations

Rabbit vas deferens: A specific bioassay for opioid κ-receptor agonists

1981 • 180 citations

Intracerebroventricular Infusion of Aldosterone Induces Hypertension in Rats*

1986 • 178 citations

β-Endorphin: Possible Involvement in the Antihypertensive Effect of Central α-Receptor Activation

1981 • 163 citations

Interconverting mu and delta forms of the opiate receptor in rat striatal patches.

1981 • 159 citations

NALOXONE REVERSES THE ANTIHYPERTENSIVE EFFECT OF CLONIDINE

1979 • 153 citations

Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.

1980 • 141 citations

Evidence favouring the Existence of a Single Adrenergic Receptor

1968 • 107 citations

A protein-lipid model of the opiate receptor

1980 • 105 citations

Cardiovascular effects of β-endorphin after microinjection into the nucleus tractus solitarii of the anaesthetised rat

1982 • 92 citations

beta-endorphin acting on the brainstem is involved in the antihypertensive action of clonidine and alpha-methyldopa in rats.

1983 • 63 citations

Multiple opioid receptors in endotoxic shock: evidence for delta involvement and mu-delta interactions in vivo.

1984 • 63 citations

Mu receptors at discrete hypothalamic and brainstem sites mediate opioid peptide-induced increases in central sympathetic outflow

1986 • 62 citations

Allosteric modulation by leucine-enkephalin of [3H]naloxone binding in rat brain

1981 • 57 citations

Mechanism of inverse regulation of alpha1- and beta-adrenergic receptors

1987 • 49 citations

Adrenergic reactivity of the myocardium in hypertension

1978 • 49 citations

Time-dependent conversion of alpha 1- to beta-adrenoceptor-mediated glycogenolysis in isolated rat liver cells: role of membrane phospholipase A2.

1984 • 43 citations

A COMPARISON OF THE CARDIOVASCULAR AND SEDATIVE ACTIONS OF THE α‐ADRENOCEPTOR AGONISTS, FLA‐136 AND CLONIDINE, IN THE RAT

1982 • 39 citations

Central cardiovascular effects of κ agonists dynorphin-(1–13) and ethylketocyclazocine in the anaesthetized rat

1983 • 38 citations

Selective δ-opioid receptor antagonism by ICI 174,864 in the central nervous system

1984 • 34 citations

Sites of Action of Clonidine: Centrally Mediated Increase in Vagal Tone, Centrally Mediated Hypotensive and Sympatho-inhibitory Effects

1977 • 31 citations

Endorphinergic mechanism in the central cardiovascular and analgesic effects of clonidine

1987 • 31 citations

Clonidine stimulated the release of dynorphin in the spinal cord of the rat: A possible mechanism for its depressor effects

1986 • 30 citations

Analysis of cardiovascular effects of morphine in the cat

1986 • 30 citations

Opioid-Mediated Cardiovascular Effects of Clonidine in Spontaneously Hypertensive Rats: Elimination by Neonatal Treatment with Monosodium Glutamate*

1986 • 27 citations

On the relationship between clonidine hypotension and brain beta-endorphin in the spontaneously hypertensive rat: studies with alpha adrenergic and opiate blockers.

1987 • 22 citations

The sensitivity of opioid receptor types to regulation by sodium and GTP

1984 • 21 citations

Effect of clonidine and naloxone on the pressor response during contraction of cat hind-limb muscles

1985 • 19 citations

Endorphins and the hypotensive response to stimulation of alpha-receptors in the brainstem by alpha-methylnoradrenaline

1984 • 16 citations

Effect of Naloxone on the Hypotensive Action of Clonidine in the Conscious, Normotensive Goat

1983 • 13 citations

Antihypertensive activity of tibalosine (CP 804 S) in the rat. Possible involvement of a central alpha 1-adrenergic receptor blockade.

1984 • 4 citations