Pharmacokinetics of morphine in plasma and discrete areas of the rat brain

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Advances in Drug Research

1964 • 615 citations

Drug and tracer kinetics

1966 • 452 citations

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

1968 • 303 citations

Some Formal Approaches to the Analysis of Kinetic Data in Terms of Linear Compartmental Systems

1962 • 169 citations

Quantitative determination of morphine in serum by radioimmunoassay.

1971 • 116 citations

Analgesic Action and Brain and Plasma Levels of Morphine and Codeine in Morphine Tolerant, Codeine Tolerant and Non‐Tolerant Rats

1964 • 95 citations

Quantitative determination of morphine in biological samples by gas-liquid chromatography and electron-capture detection

1975 • 73 citations

Drug distribution and pharmacologic effects

1971 • 67 citations

Disposition of Morphine in Man

1971 • 64 citations

Multicompartment Pharmacokinetic Models and Pharmacologic Effects

1969 • 62 citations

Distribution of N-C-14-methyl labeled morphine. I. In central nervous system of nontolerant and tolerant dogs.

1962 • 56 citations

The influence of physiologic and pharmacologic factors on the disposition of morphine as determined by radioimmunoassay.

1974 • 48 citations

Intracerebral distribution pattern of radioactive morphine and morphine-like drugs after intraventricular and intrathecal injection

1970 • 47 citations

Transport of narcotic analgesics by choroid plexus and kidney tissue in vitro

1967 • 47 citations

Rat tissue levels of carbon-14 labeled analgetics as related to pharmacological activity.

1955 • 46 citations

Studies on the uptake of morphine by the choroid plexus in vitro.

1966 • 38 citations

The precursor-product relationship.

1961 • 32 citations

Application of clearance concepts to some literature data on drug metabolism in the isolated perfused liver preparation and in vivo

1972 • 28 citations

Physiological Disposition of Narcotic Agonists and Antagonists

1971 • 25 citations

Advances in Drug Research, vol. 5

1971 • 21 citations

Studies on the Relationship between Morphine Analgesia and the Brain Catecholamines in Mice

1971 • 20 citations

Pentazocine analgesia and regional rat brain catecholamines

1974 • 19 citations

Distribution of N-C-14-methyl labeled morphine. II. Effect of nalorphine in the central nervous system of nontolerant dogs and observations on metabolism.

1962 • 18 citations

Studies on the Relationship between the Analgesic Activity of Salicylic Acid and the Brain Catecholamines in Mice

1973 • 17 citations

Studies on the transport of morphine into the cerebrospinal fluid of rabbits.

1972 • 15 citations

Blood and brain concentration of morphine and its relation to the analgesic activity in mice.

1971 • 8 citations

Differences in the Autoradiographic Localization of Labelled Morphine‐Like Analgesics in the Mouse

1973 • 8 citations