Use of Inhibitors of γ‐Aminobutyric Acid (GABA) Transaminase for the Estimation of GABA Turnover in Various Brain Regions of Rats: A Reevaluation of Aminooxyacetic Acid

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples

1978 • 6,494 citations

Some properties of L-glutamic decarboxylase in mouse brain

1963 • 335 citations

THE FLUORIMETRIC MEASUREMENT OF GLUTAMIC DECARBOXYLASE and ITS DISTRIBUTION IN BRAIN*

1958 • 330 citations

Studies on the GABA pathway—I

1961 • 287 citations

Benzodiazepine receptors

1984 • 253 citations

The Distribution of Glutamic-γ-Aminobutyric Transaminase in the Nervous System of the Rhesus Monkey

1959 • 192 citations

Effect of Inhibitors of GABA Transaminase on the Synthesis, Binding, Uptake and Metabolism of GABA

1980 • 167 citations

Is amygdala kindling in rats a model for drug-resistant partial epilepsy?

1986 • 163 citations

Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications

1981 • 154 citations

Dynamics of neurotransmitter function

1984 • 105 citations

Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

1981 • 98 citations

Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs

1982 • 86 citations

The Use of Inhibitors of GABA‐Transaminase for the Determination of GABA Turnover in Mouse Brain Regions: An Evaluation of Aminooxyacetic Acid and Gabaculine

1982 • 85 citations

STABILITY OF SYNAPTOSOMAL GABA LEVELS AND THEIR USE IN DETERMINING THE IN VIVO EFFECTS OF DRUGS: CONVULSANT AGENTS

1979 • 85 citations

A comparative study of the pharmacology of inhibitors of GABA-metabolism

1980 • 83 citations

Effect of aminooxyacetic acid, thiosemicarbazide and haloperidol on the metabolism and half-lives of glutamate and GABA in rat brain

1973 • 82 citations

The effect of aminooxyacetic acid on the metabolism of γ-aminobutyric acid in brain

1966 • 79 citations

Anticonvulsant properties of amino-oxyacetic acid

1961 • 73 citations

Application of principles of steady-state kinetics to the estimation of gamma-aminobutyric acid turnover rate in nuclei of rat brain.

1977 • 73 citations

In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat

1985 • 66 citations

GABA—2-oxoglutarate transaminase, glutamate decarboxylase and the half-life of GABA in different areas of rat brain

1972 • 62 citations

Improved Method for Isolating Synaptosomes from 11 Regions of One Rat Brain: Electron Microscopic and Biochemical Characterization and Use in the Study of Drug Effects on Nerve Terminal γ‐Aminobutyric Acid in Vivo

1985 • 61 citations

Aminooxyacetic acid: Correlation between biochemical effects, anticonvulsant action and toxicity in mice

1978 • 58 citations

Contribution of the GABA Bypath to Glucose Oxidation, and the Development of Compartmentation in the Brain

1970 • 52 citations

Intracerebral injection of gamma vinyl GABA: Method for measuring rates of GABA synthesis in specific brain regions

1981 • 50 citations

EFFECTS OF AMINOOXYACETIC ACID AND <scp>l</scp>‐GLUTAMIC ACID‐γ‐HYDRAZIDE ON GABA METABOLISM IN SPECIFIC BRAIN REGIONS

1978 • 45 citations

EFFECT OF DIAZEPAM AND PENTOBARBITAL ON AMINOOXYACETIC ACID‐INDUCED ACCUMULATION OF GABA

1977 • 43 citations

Development of a synaptosomal model to determine drug-induced in vivo changes in GABA-levels of nerve endings in 11 brain regions of the rat

1984 • 43 citations

Regulation of Monoamine Synthesis and Utilization by Receptors

1980 • 41 citations

High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.

1983 • 39 citations

Relationship between drug-induced increases of GABA levels in discrete brain areas and different pharmacological effects in rats

1984 • 37 citations

Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion

1987 • 36 citations

POST‐MORTEM AND AMINOOXYACETIC ACID‐INDUCED ACCUMULATION OF GABA: EFFECT OF GAMMA‐BUTYROLACTONE AND PICROTOXIN

1978 • 32 citations

Effect of aminooxyacetic acid (AOAA) on GABA levels in some parts of the rat brain

1980 • 29 citations

Correlation between alterations in brain GABA metabolism and seizure excitability following administration of GABA aminotransferase inhibitors and valproic acid—a re-evaluation

1981 • 27 citations

Studies on the GABA pathway-II. The lack of effect of pyridoxal phosphate on GABA-KGA transaminase inhibition induced by amino-oxyacetic acid

1961 • 23 citations

Comparison of results obtained with different methods for estimating GABA turnover in rat neostriatum

1987 • 22 citations

On the importance of GABA-ergic neurons for the AOAA induced accumulation of GABA in the rat brain

1980 • 20 citations

Constant infusion of [13C6]glucose: Simultaneous measurement of turnover of GABA and glutamate in defined regions of the brain of individual animals

1988 • 19 citations

On the Use of Enzyme Inhibitors to Study the Synthesis and Utilization of Brain GABA

1984 • 19 citations

Return of γ-aminobutyrate transaminase activity in mouse brain after inhibition by aminooxyacetic acid: Chemical and histochemical observations

1967 • 14 citations

Comparative study of the inhibition of GABA aminotransferase by different anticonvulsant drugs.

1980 • 13 citations

Is the estimation of GABA turnover rate in vivo a tool to differentiate between various types of drugs interfering with the GABA/benzodiazepine/ionophore receptor complex?

1984 • 8 citations

GABA Synthesis: Its Dynamics in Relation to Glutamate and Glutamine Metabolism

1982 • 5 citations

Drug-Induced Changes of Physiologically Active Agents in the Central Nervous System and Their Significance

1969 • 1 citations