Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Sigma receptors: biology and function.

1990 • 799 citations

A proposal for the classification of sigma binding sites

1992 • 743 citations

Beta adrenergic receptor binding in membrane preparations from mammalian brain.

1976 • 576 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

1984 • 348 citations

Classification and nomenclature of phencyclidine and sigma receptor sites

1987 • 272 citations

Naloxone-inaccessible sigma receptor in rat central nervous system.

1983 • 214 citations

Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.

1984 • 199 citations

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

1983 • 187 citations

Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain

1988 • 176 citations

Synthesis and evaluation of optically pure [³H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors

1989 • 141 citations

Phencyclidine and σ opiate receptors in brain: Biochemical and autoradiographical differentiation

1985 • 124 citations

NE-100, a novel sigma receptor ligand: In vivo tests

1993 • 116 citations

Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors

1984 • 104 citations

High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.

1983 • 96 citations

Sigma opioid receptor: characterization and co-identity with the phencyclidine receptor.

1985 • 86 citations

Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.

1989 • 85 citations

NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain

1994 • 82 citations

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (σ sites) exhibit a unique distribution in rat brain subcellular fractions

1990 • 72 citations

High-affinity dextromethorphan binding sites in guinea pig brain. I. Initial characterization.

1983 • 71 citations

[3H]DTG and [3H](+)-3-PPP label pharmacologically distinct σ binding sites in guinea pig brain membranes

1991 • 66 citations

Psychotomimetic opiate receptors labelled and visualized with (+)[^3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine

1984 • 57 citations

Phencyclidine/SKF-10,047 binding sites: Evaluation of function

1989 • 50 citations

Computer-assisted modeling of multiple dextromethorphan and sigma binding sites in guinea pig brain

1991 • 49 citations

Heterogeneous Binding of Sigma Radioligands in the Rat Brain and Liver: Possible Relationship to Subforms of Cytochrome P‐450

1991 • 39 citations

Stereoselective behavioral effects of N-allylnormetazocine in pigeons and squirrel monkeys.

1985 • 38 citations

Receptor site topographies for phencyclidine-like and sigma drugs: predictions from quantitative conformational, electrostatic potential, and radioreceptor analyses.

1988 • 36 citations

Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites

1988 • 30 citations

Allosteric modulation of dextromethorphan binding sites

1987 • 23 citations

H1 antihistamines interact with central sigma receptors

1990 • 20 citations

[3H]DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'- oxoethyl)-piperidine HBr]: a receptor binding profile of a high-affinity novel sigma receptor ligand in guinea pig brain.

1992 • 14 citations

FH-510, a potent and selective ligand for rat brain σ recognition sites

1993 • 9 citations

Binding of [3H]FH-510 to σ ligand recognition sites in guinea-pig brain membranes

1993 • 1 citations

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