CD3/CD28-costimulated T1 and T2 subsets: differential in vivo allosensitization generates distinct GVT and GVHD effects

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

1999 • 1,218 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts

1985 • 517 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells.

1997 • 337 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Generation and in vivo persistence of polarized Th1 and Th2 memory cells

1994 • 283 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer.

1998 • 252 citations

Differential roles of IL-1 and TNF-α on graft-versus-host disease and graft versus leukemia

1999 • 249 citations

Differential Effects of Anti-Fas Ligand and Anti-Tumor Necrosis Factor α Antibodies on Acute Graft-Versus-Host Disease Pathologies

1998 • 228 citations

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

1994 • 210 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

Successful Treatment of Metastatic Renal Cell Carcinoma With a Nonmyeloablative Allogeneic Peripheral-Blood Progenitor-Cell Transplant: Evidence for a Graft-Versus-Tumor Effect

1999 • 203 citations

Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells.

1996 • 201 citations

Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect

2001 • 187 citations

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

1998 • 179 citations

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

2001 • 174 citations

Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection

2002 • 169 citations

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4⁺ T cells and induce similar patterns of cytokine secretion in vitro

1995 • 152 citations

Graft-Versus-Leukemia Effect and Graft-Versus-Host Disease Can Be Differentiated by Cytotoxic Mechanisms in a Murine Model of Allogeneic Bone Marrow Transplantation

1999 • 144 citations

Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function

1997 • 141 citations

Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.

1996 • 137 citations

Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

1995 • 129 citations

Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences.

1985 • 125 citations

Therapeutic Effects of Tumor-Reactive Type 1 and Type 2 CD8+ T Cell Subpopulations in Established Pulmonary Metastases

1999 • 115 citations

CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4.

1993 • 112 citations

Involvement of Donor T-Cell Cytotoxic Effector Mechanisms in Preventing Allogeneic Marrow Graft Rejection

1998 • 90 citations

The Role of Adoptively Transferred CD8 T Cells and Host Cells in the Control of the Growth of the EG7 Thymoma: Factors That Determine the Relative Effectiveness and Homing Properties of Tc1 and Tc2 Effectors

2001 • 85 citations

Type 1 and Type 2 CD8+ Effector T Cell Subpopulations Promote Long-Term Tumor Immunity and Protection to Progressively Growing Tumor

2000 • 84 citations

CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation

1999 • 78 citations

T Cells Coactivated with Immobilized Anti-CD3 and Anti-CD28 as Potential Immunotherapy for Cancer

1999 • 77 citations

Active Vaccination Against IL-5 Bypasses Immunological Tolerance and Ameliorates Experimental Asthma

2001 • 77 citations

Interleukin-12 Inhibits Graft-Versus-Host Disease Through an Fas-Mediated Mechanism Associated With Alterations in Donor T-Cell Activation and Expansion

1998 • 76 citations

Allogeneic cell therapy for a murine mammary carcinoma.

1998 • 75 citations

Fas-DeficientlprMice Are More Susceptible to Graft-Versus-Host Disease

2000 • 72 citations

Differential Dynamics of CD4⁺and CD8⁺T-Lymphocyte Proliferation and Activation in Acute Simian Immunodeficiency Virus Infection

2000 • 69 citations

Allospecific CD4+, Th1/Th2 and CD8+, Tc1/Tc2 populations in murine GVL: type I cells generate GVL and type II cells abrogate GVL.

1996 • 63 citations

Functional skewing of bone marrow-derived dendritic cells by Th1- or Th2-inducing cytokines

1999 • 59 citations

Immunopotentiating Role of IFN-γ in Early and Late Stages of Type 1 CD8 Effector Cell-Mediated Tumor Rejection

2001 • 56 citations

Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-β–treated alloreactive T cells that do not induce graft-versus-host disease

2001 • 49 citations

Immune Modulation in Cancer Patients After Adoptive Transfer of Anti-CD3/Anti-CD28–Costimulated T Cells—Phase I Clinical Trial

2001 • 43 citations

CD3-mediated activation of tumor-reactive lymphocytes from patients with advanced cancer

2001 • 41 citations

A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo

2000 • 33 citations

Anti-CD3/Anti-CD28 Bead Stimulation Overcomes CD3 Unresponsiveness in Patients With Head and Neck Squamous Cell Carcinoma

2000 • 31 citations

Antibody-dependent cell-mediated cytolysis (ADCC) with antibody-coated effectors: new methods for enhancing antibody binding and cytolysis.

1980 • 18 citations

Modulation of graft-versus-tumor effects in a murine allogeneic bone marrow transplantation model by tumor-derived transforming growth factor-betaI

2001 • 14 citations

Graft-versus-leukemia for AKR spontaneous leukemia-lymphoma.

1976 • 10 citations