Oligomerization of Expanded-Polyglutamine Domain Fluorescent Fusion Proteins in Cultured Mammalian Cells

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

1997 • 1,283 citations

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2

1996 • 1,081 citations

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases.

1994 • 1,065 citations

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

1996 • 824 citations

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT

1996 • 745 citations

Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

1995 • 646 citations

A huntingtin-associated protein enriched in brain with implications for pathology

1995 • 597 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivo

1996 • 546 citations

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

1995 • 445 citations

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH

1996 • 435 citations

HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

1997 • 384 citations

HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system

1997 • 335 citations

Organization of organelles and membrane traffic by microtubules

1995 • 324 citations

Trinucleotide Repeats in Neurogenetic Disorders

1996 • 323 citations

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.

1995 • 299 citations

Expression analysis of the ataxin–1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

1995 • 294 citations

Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.

1995 • 223 citations

Glutamine repeats and inherited neurodegenerative diseases: molecular aspects

1996 • 206 citations

Abnormal gene product identified in hereditary dentatorubral–pallidoluysian atrophy (DRPLA) brain

1995 • 160 citations

The cortical neuritic pathology of Huntington's disease

1995 • 89 citations

Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS.

1995 • 81 citations

Immunohistochemical localization and immunoblotting of androgen receptor in spinal neurons of male and female rats

1996 • 47 citations

Association of vimentin intermediate filaments with the centrosome

1995 • 45 citations

Toxicity of expanded polyglutamine‐domain proteins in Escherichia coli

1996 • 44 citations

Specific and quantitative immunoprecipitation of tropomyosin and other cytoskeletal proteins by magnetic separation.

1993 • 8 citations