Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

[49] Rapid DNA isolations for enzymatic and hybridization analysis

1980 • 572 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.

1982 • 410 citations

Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver

1967 • 410 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

1983 • 366 citations

Lessons from Animal Diabetes

1984 • 358 citations

Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring.

1981 • 320 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Gluconeogenesis: Its regulation in mammalian species

1977 • 259 citations

Cloning and nucleotide sequencing of the bovine growth hormone gene

1982 • 214 citations

Rapid changes in the concentration of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney. Effects of insulin and cyclic AMP.

1982 • 199 citations

Phosphoenolpyruvate carboxykinase. I. Its ce:role in gluconeogenesis

1972 • 178 citations

Primary structure of the gene encoding rat preprosomatostatin.

1984 • 161 citations

Gluconeogenesis, its regulation in mammalian species

1976 • 159 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.

1987 • 155 citations

Induction of phosphopyruvate carboxylase in neonatal rat liver by adenosine 3',5'-cyclic monophosphate

1968 • 130 citations

cDNA and gene nucleotide sequence of porcine plasminogen activator

1984 • 116 citations

The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids.

1975 • 112 citations

Rapid Loss of Translatable Messenger RNA of Phosphoenolpyruvate Carboxykinase During Glucose Repression in Liver

1974 • 111 citations

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

1987 • 109 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers.

1986 • 103 citations

Structure and tissue-specific expression of the human metallothionein IB gene.

1986 • 89 citations

Glucocorticoids and the regulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in the rat

1975 • 87 citations

Insulin decreases phosphoenolpyruvate carboxykinase (GTP) mRNA activity by a receptor-mediated process.

1982 • 74 citations

Changes in hepatic messenger RNA for phospho enol pyruvate carboxykinase (GTP) during development

1978 • 63 citations

Alterations in translatable messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) in rat liver cytosol during deinduction.

1978 • 62 citations

Messenger RNA for renal phosphoenolpyruvate carboxykinase (GTP). Its translation in a heterologous cell-free system and its regulation by glucocorticoids and by changes in acid-base balance

1977 • 60 citations

Alternative processing of bovine growth hormone mRNA: nonsplicing of the final intron predicts a high molecular weight variant of bovine growth hormone.

1987 • 54 citations

Trans regulation of the phosphoenolpyruvate carboxykinase (GTP) gene, identified by deletions in chromosome 7 of the mouse.

1986 • 52 citations

Regulation of rat liver phosphoenolpyruvate carboxykinase (GTP) messenger ribonucleic acid activity by N6,O2'-dibutyryladenosine 3',5'-phosphate

1981 • 52 citations

The regulation of phosphoenolpyruvate carboxykinase in fetal rat liver.

1973 • 47 citations

Gluconeogenesis in developing rat kidney cortex

1969 • 40 citations

The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex

1972 • 39 citations

Synthesis of bovine growth hormone in primates by using a herpesvirus vector.

1985 • 37 citations

Developmental acquisition of DNase I sensitivity of the phosphoenolpyruvate carboxykinase (GTP) gene in rat liver.

1987 • 36 citations

The gene encoding the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken.

1984 • 27 citations

Influence of Diet, Cortisol and Insulin on the Activity of Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase in the Rat Liver

1976 • 26 citations

Stimulation of growth hormone synthesis by glucose in islets of Langerhans isolated from transgenic mice.

1986 • 15 citations