Autoimmunity to glutamic acid decarboxylase (GAD) in stiffman syndrome and insulin-dependent diabetes mellitus

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions

1991 • 781 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Inducible expression of H–2 and Ia antigens on brain cells

1984 • 656 citations

Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome

1990 • 618 citations

Autoantibodies to Glutamic Acid Decarboxylase in a Patient with Stiff-Man Syndrome, Epilepsy, and Type I Diabetes Mellitus

1988 • 542 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

1982 • 531 citations

Production of a specific antiserum to rat brain glutamic acid decar☐ylase by injection of an antigen-antibody complex

1981 • 424 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

1991 • 382 citations

Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase

1988 • 334 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Organ‐Specific Autoimmunity: A 1986 Overview

1986 • 274 citations

Immunocytochemical localization of the GABA transporter in rat brain

1990 • 209 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

A critical survey of stiff-man syndrome

1967 • 197 citations

Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein

1987 • 187 citations

Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder

1989 • 167 citations

A syndrome of asymmetric limb weakness with motor conduction block

1990 • 166 citations

GABA and neuropeptides in the CNS

1985 • 133 citations

Stiff‐person syndrome: An autoimmune disease

1991 • 124 citations

The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine.

1984 • 124 citations

Immunohistochemical Studies of the GABA System in the Pancreas

1983 • 103 citations

Sudden death and paroxysmal autonomic dysfunction in stiff-man syndrome

1991 • 96 citations

Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse

1990 • 88 citations

Characterization of a cDNA coding for rat glutamic acid decarboxylase

1990 • 80 citations

Rat Brain Glutamic Acid Decarboxylase Sequence Deduced from a Cloned cDNA

1990 • 77 citations

Revelation of Specificity of 64K Autoantibodies in IDDM Serums by High-Resolution 2-D Gel Electrophoresis: Unambiguous Identification of 64K Target Antigen

1989 • 66 citations

Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells.

1990 • 66 citations

Evidence for Two Distinct Forms of Native Glutamic Acid Decarboxylase in Rat Brain Soluble Extract: An Immunoblotting Study

1987 • 62 citations

Mapping of epitopes on the La(SS-B) autoantigen of primary Sjögren's syndrome: identification of a cross-reactive epitope.

1990 • 61 citations

Stiffman syndrome: a rare paraneoplastic disorder?

1990 • 58 citations

Resolution of Stiff-Man Syndrome with Cortisol Replacement in a Patient with Deficiencies of ACTH, Growth Hormone, and Prolactin

1984 • 50 citations

Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: Further evidence for non-neural GABA systems

1989 • 47 citations

Anatomy, physiology, and pathology of epilepsy

1990 • 46 citations

Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.

1990 • 36 citations

Environmental factors and insulin‐dependent diabetes mellitus

1987 • 35 citations

The 64-kDa Beta Cell Membrane Autoantigen and Other Target Molecules of Humoral Autoimmunity in Insulin-Dependent Diabetes Mellitus

1990 • 31 citations

Self-tolerance and autoimmunity

1991 • 30 citations

Immunopathogenesis and Immunotherapy of Type 1 Diabetes

1990 • 26 citations

Stiff‐man syndrome: A GABAergic autoimmune disorder with autoantigenic heterogeneity

1990 • 24 citations

Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen

1989 • 22 citations