Multiple Transcripts for the Human Cardiac Form of the cGMP-inhibited cAMP Phosphodiesterase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

The scanning model for translation: an update.

1989 • 3,525 citations

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

On Finding All Suboptimal Foldings of an RNA Molecule

1989 • 2,019 citations

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

1982 • 1,539 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas

1988 • 481 citations

Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID.

1988 • 477 citations

Bifunctional messenger RNAs in eukaryotes

1986 • 405 citations

An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1970 • 346 citations

Effect of Insulin on Adenosine 3‘,5‘-Monophosphate in the Rat Epididymal Fat Pad

1966 • 340 citations

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

1988 • 313 citations

The HTS1 gene encodes both the cytoplasmic and mitochondrial histidine tRNA synthetases of S. cerevisiae

1986 • 308 citations

Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase.

1986 • 253 citations

An Effect of Insulin on Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase Activity in Fat Cells

1973 • 245 citations

Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs.

1986 • 230 citations

Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.

1975 • 203 citations

Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases.

1990 • 174 citations

Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.

1990 • 174 citations

Mitochondrial and cytoplasmic fumarases in Saccharomyces cerevisiae are encoded by a single nuclear gene FUM1.

1987 • 168 citations

Cyclic GMP phosphodiesterase from cattle retina

1986 • 167 citations

Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin

1988 • 165 citations

Effect of Insulin and Lipolytic Agents on Rat Adipocyte Low K Cyclic Adenosine 3′ : 5′-Monophosphate Phosphodiesterase

1974 • 165 citations

Bovine cone photoreceptor cGMP phosphodiesterase structure deduced from a cDNA clone.

1990 • 160 citations

Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.

1992 • 158 citations

Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets.

1988 • 146 citations

Distinct repressible mRNAs for cytoplasmic and secreted yeast invertase are encoded by a single gene

1981 • 144 citations

Effects of Insulin on the Levels of Adenosine 3′:5′-Monophosphate and Lipolysis in Isolated Rat Epididymal Fat Cells

1973 • 144 citations

Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae.

1986 • 143 citations

Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.

1993 • 137 citations

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

1990 • 133 citations

Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.

1987 • 123 citations

Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation

1991 • 119 citations

Hormonal Regulation of Adipocyte Enzymes

1973 • 116 citations

Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase

1984 • 115 citations

Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants.

1991 • 111 citations

Molecular cloning of a cDNA encoding the “61-kDa” calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms.

1993 • 99 citations

Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene. Evidence for a negative regulatory element that controls initiation at the proximal site

1993 • 92 citations

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

1994 • 92 citations

Structure of yeast LEU4. The 5' flanking region contains features that predict two modes of control and two productive translation starts.

1986 • 89 citations

Cyclic GMP phosphodiesterase from bovine retina Amino acid sequence of the α‐subunit and nucleotide sequence of the corresponding cDNA

1987 • 89 citations

cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity.

1988 • 80 citations

Activation of the particulate low Km phosphodiesterase of adipocytes by addition of cAMP-dependent protein kinase.

1988 • 78 citations

Genetic dissection of the learning/memory gene dunce of Drosophila melanogaster.

1993 • 76 citations

The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

1993 • 75 citations

Amino acid sequence of the cyclic GMP stimulated cyclic nucleotide phosphodiesterase from bovine heart

1990 • 60 citations

HTS1 encodes both the cytoplasmic and mitochondrial histidyl-tRNA synthetase of Saccharomyces cerevisiae: mutations alter the specificity of compartmentation.

1992 • 52 citations

Insulin-dependent and insulin-independent low Km cyclic AMP phosphodiesterase from rat adipose tissue.

1982 • 51 citations

Purification and properties of the cGMP-inhibited cAMP phosphodiesterase from bovine aortic smooth muscle

1992 • 48 citations

Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase

1994 • 46 citations

Cytosolic and Sarcoplasmic Reticulum-Associated Low Km, cGMP-Inhibited cAMP Phosphodiesterase in Mammalian Myocardium

1993 • 45 citations

Mutational mapping of kinetic and pharmacological properties of a human cardiac cAMP phosphodiesterase.

1994 • 42 citations

Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets

1992 • 42 citations

Stimulation by Insulin of a Serine Kinase in Human Platelets That Phosphorylates and Activates the cGMP-Inhibited cAMP Phosphodiesterase

1993 • 33 citations

Cell-free stimulation of the insulin-sensitive cAMP phosphodiesterase by the joint actions of ATP and the soluble fraction from insulin-treated rat liver

1990 • 13 citations

Purification and characterization of guanosine 3',5'-monophosphate-inhibited low K(m) adenosine 3',5'-monophosphate phosphodiesterase from human placental cytosolic fractions.

1992 • 11 citations

The role of COOH-terminal and acidic domains in the activity and stability of human insulin receptor protein tyrosine kinase studied by purified deletion mutants of the beta subunit domain.

1993 • 10 citations

Characterization of Human Placental Cytosolic Adenosine 3′,5′-Monophosphate Phosphodiest erase by Inhibitors and Insulin Treatment*

1990 • 8 citations