Multimeric Coactivator Complexes for Steroid/Nuclear Receptors

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

1997 • 856 citations

A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex

1999 • 788 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation

1998 • 609 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

1996 • 556 citations

Histone-like TAFs within the PCAF Histone Acetylase Complex

1998 • 534 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1

1999 • 460 citations

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

1996 • 453 citations

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast

1988 • 441 citations

Composite co-activator ARC mediates chromatin-directed transcriptional activation

1999 • 429 citations

Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

1999 • 421 citations

A novel protein complex that interacts with the vitamin D₃ receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

1998 • 391 citations

The histone acetylase PCAF is a nuclear receptor coactivator

1998 • 389 citations

Phosphorylation of the Nuclear Receptor SF-1 Modulates Cofactor Recruitment

1999 • 374 citations

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1

1999 • 350 citations

Genetic Analysis of Histone H4: Essential Role of Lysines Subject to Reversible Acetylation

1990 • 346 citations

Interdomain communication regulating ligand binding by PPAR-γ

1998 • 344 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

1998 • 305 citations

Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

1999 • 291 citations

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

1999 • 274 citations

CREB-Binding Protein Acetylates Hematopoietic Transcription Factor GATA-1 at Functionally Important Sites

1999 • 242 citations

NAT, a Human Complex Containing Srb Polypeptides that Functions as a Negative Regulator of Activated Transcription

1998 • 235 citations

Histone acetyltransferases regulate HIV-1 enhancer activity in vitro

1997 • 183 citations

Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding

1998 • 180 citations

Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase

1998 • 161 citations

Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin

1998 • 139 citations

Brzozowski, A M. et al. Molecular basis of agonism and antagonism in the estrogen receptor. Nature 389, 753-758

1997 • 43 citations