Amino Acid Residues in Thrombin-sensitive Region and First Epidermal Growth Factor Domain of Vitamin K-dependent Protein S Determining Specificity of the Activated Protein C Cofactor Function

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity

1981 • 4,191 citations

A simple method for the preparation of homogeneous phospholipid vesicles

1977 • 861 citations

Familial protein S deficiency is associated with recurrent thrombosis.

1984 • 614 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 516 citations

Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation.

1981 • 397 citations

High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein.

1981 • 373 citations

The Molecular Basis of Blood Diseases

1994 • 370 citations

Inherited resistance to activated protein C iscorrected by anticoagulant cofactor activity found to be a property of factorV.

1994 • 359 citations

Escherichia coli K-12 restricts DNA containing 5-methylcytosine.

1986 • 325 citations

Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa.

1994 • 307 citations

Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein.

1986 • 296 citations

The protein C anticoagulant system: Inherited defects as basis for venous thrombosis

1995 • 286 citations

A simple and rapid method for the selection of oligodeoxynucleotide-directed mutants

1988 • 274 citations

Effects of Protein S and Factor Xa on Peptide Bond Cleavages during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C

1995 • 233 citations

Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.

1993 • 220 citations

Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.

1986 • 204 citations

Interaction of vitamin K dependent proteins with membranes

1978 • 193 citations

Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C.

1994 • 177 citations

Protein S binds to and inhibits factor Xa.

1994 • 167 citations

Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa.

1994 • 157 citations

Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin.

1975 • 143 citations

Primary structure of bovine vitamin K-dependent protein S.

1986 • 126 citations

Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies.

1990 • 112 citations

An update on clinical and basic aspects of the protein C anticoagulant pathway

1995 • 107 citations

Protein S is required for bovine platelets to support activated protein C binding and activity.

1985 • 105 citations

Cultured bovine aortic endothelial cells promote activated protein C-protein S-mediated inactivation of factor Va.

1986 • 103 citations

Protein S Alters the Active Site Location of Activated Protein C above the Membrane Surface

1997 • 103 citations

Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene

1995 • 94 citations

The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C

1992 • 83 citations

Assembly of protein S and C4b-binding protein on membranes.

1990 • 78 citations

Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles

1992 • 75 citations

Regulation of bovine activated protein C by protein S: The role of the cofactor protein in species specificity

1981 • 71 citations

Active site selective labeling of serine proteases with spectroscopic probes using thioester peptide chloromethyl ketones: demonstration of thrombin labeling using N.alpha.[(acetylthio)acetyl]-D-Phe-Pro-Arg-Ch2Cl

1988 • 66 citations

Protein S Is Essential for the Activated Protein C-Catalyzed Inactivation of Platelet-Associated Factor Va1

1984 • 62 citations

Regulation of Activated Protein C by Thrombin-Modified Protein S1

1983 • 59 citations

A Chimeric Protein C Containing the Prothrombin Gla Domain Exhibits Increased Anticoagulant Activity and Altered Phospholipid Specificity

1998 • 52 citations

The SHBG‐like region of protein S is crucial for factor V‐dependent APC‐cofactor function

1998 • 48 citations

A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S: from biostructural pathology to species-specific cofactor activity.

1997 • 39 citations

Human Protein S Cleavage and Inactivation by Coagulation Factor Xa

1998 • 37 citations

Expression and Functional Characterization of Chimeras Between Human and Bovine Vitamin‐K‐dependent Protein‐S‐defining Modules Important for the Species Specificity of the Activated Protein C Cofactor Activity

1995 • 35 citations

Vitamin K-dependent protein S in Leydig cells of human testis

1994 • 33 citations

Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C

1995 • 30 citations

Molecular cloning, expression and functional characterization of rabbit anticoagulant vitamin‐K‐dependent protein S

1993 • 30 citations

The Effect of N-linked Glycosylation on Molecular Weight, Thrombin Cleavage, and Functional Activity of Human Protein S

1997 • 28 citations

Gamma-carboxylated isoforms of recombinant human protein S with different biologic properties

1990 • 27 citations

Characterization of recombinant epidermal growth factor (EGF)‐like modules from vitamin‐K‐dependent protein S expressed in Spodoptera cells

1998 • 27 citations

Molecular Cloning and Functional Characterization of Rat Plasma Protein S

1995 • 27 citations

A Mutation of the Active Protein S Gene Leading to an EGF1-Lacking Protein in a Family With Qualitative (Type II) Deficiency

1998 • 23 citations

Expression of completely γ‐carboxylated and β‐hydroxylated recombinant human vitamin‐K‐dependent protein S with full biological activity

1990 • 20 citations

E1a-responsive mammalian host/vector system for the stable high-level expression of secreted proteins

1992 • 13 citations