BEHAVIORAL EFFECTS OF SEROTONIN NEUROTOXINS: AN OVERVIEW*

Habituation: A dual-process theory.

1970 • 2,096 citations

Biogenic Amines and the States of Sleep

1969 • 1,274 citations

Amphetamines and related compounds

1971 • 979 citations

Neurophysiology of the states of sleep.

1967 • 803 citations

STUDIES IN VIVO ON THE RELATIONSHIP BETWEEN BRAIN TRYPTOPHAN, BRAIN 5‐HT SYNTHESIS AND HYPERACTIVITY IN RATS TREATED WITH A MONOAMINE OXIDASE INHIBITOR AND L‐TRYPTOPHAN

1971 • 667 citations

A CONCEPT FOR A ROLE OF SEROTONIN AND NOREPINEPHRINE AS CHEMICAL MEDIATORS IN THE BRAIN

1957 • 637 citations

An animal behavior model for studying central serotonergic synapses

1976 • 555 citations

Serotonin and Behavior

1973 • 543 citations

HABITUATION OF THE AROUSAL REACTION

1956 • 534 citations

The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat

1967 • 431 citations

Sexual Behavior: Pharmacology and Biochemistry

1975 • 415 citations

Serotonin-containing neurons: their possible role in pain and analgesia

1977 • 394 citations

Morphine analgesia: Blockade by raphe magnus lesions

1975 • 353 citations

Monoaminergic mechanisms of stimulation-produced analgesia

1975 • 345 citations

Differential behavioral and neurochemical effects following lesions of the dorsal or median raphe nuclei in rats

1974 • 334 citations

Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways

1976 • 311 citations

Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor

1968 • 301 citations

Studies on behavioral and biochemical changes in rats after lesion of midbrain raphé

1968 • 294 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

Control of brain neurotransmitter synthesis by precursor availability and nutritional state

1976 • 271 citations

Compulsive Sexual Activity Induced by p -Chlorophenylalanine in Normal and Pinealectomized Male Rats

1969 • 255 citations

The effect of p-chlorophenylalanine on behavior in rats: relation to brain serotonin and 5-hydroxyindoleacetic acid

1969 • 243 citations

Factors affecting the action of narcotics

1978 • 243 citations

Hyperphagia and Obesity Following Serotonin Depletion by Intraventricular p -Chlorophenylalanine

1976 • 241 citations

Hyperphagia and Increased Growth in Rats After Intraventricular Injection of 5,7-Dihydroxytryptamine

1976 • 208 citations

Altered sensitivity to footshock and decreased brain content of serotonin following brain lesions in the rat.

1969 • 206 citations

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

1974 • 205 citations

Behavioral effects of selective midbrain raphe lesions in the rat

1975 • 201 citations

Serotonergic inhibition of catecholamine-induced behavioral arousal

1973 • 200 citations

Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms.

1975 • 200 citations

Behavioral effects of serotonin depletion and of p-chlorophenylalanine (a serotonin depletor) in rats

1970 • 196 citations

Behavioral evidence for supersensitivity following destruction of central serotonergic nerve terminals by 5,7-dihydroxytryptamine.

1976 • 182 citations

The aggressive monoamines.

1973 • 182 citations

Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by <scp>l</scp>‐tryptophan or 5‐methoxy‐N,N‐dimethyltryptamine in rats treated with a monoamine oxidase inhibitor

1971 • 179 citations

Feeding and temperature responses in the unrestrained rat after injections of cholinergic and aminergic substances into the cerebral ventricles

1968 • 177 citations

Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues

1977 • 170 citations

Pharmacological tests for the function of hypothalamic norepinephrine in eating behavior

1969 • 169 citations

Behavioral and biochemical interactions of 5,7-dihydroxy-tryptamine with various drugs when administered intracisternally to adult and developing rats

1975 • 166 citations

Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs

1972 • 165 citations

Evidence for Inhibition by Brain Serotonin of Mouse Killing Behaviour in Rats

1971 • 165 citations

The effect of para-chlorophenylalanine on spontaneous locomotor activity in the rat

1971 • 159 citations

Serotonergic and cholinergic involvement in habituation of activity and spontaneous alternation of rats in a maze.

1972 • 155 citations

p -Chloroamphetamine: Selective Neurotoxic Action in Brain

1975 • 147 citations

Stimulation of the midbrain raphe: effect on serotonin metabolism.

1968 • 147 citations

Behavioral and neurochemical effects of lesions in the raphe system of the rat.

1971 • 146 citations

"Hypersexuality" and Behavioral Changes in Cats Caused by Administration of p -Chlorophenylalanine

1970 • 146 citations

Differential behavioral effects of lesions of the medial or dorsal raphe nuclei in rats: Open field and pain-elicited aggression.

1976 • 145 citations

Central monoamines and antinociceptive drug action

1972 • 143 citations

Effects of Long-Term Corn Consumption on Brain Serotonin and the Response to Electric Shock

1975 • 143 citations

Behavioral effects of 5,7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways

1976 • 143 citations

The effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine

1972 • 143 citations

Treatment of an adrenal cortical carcinoma with a combination of o,p′-DDD and aminoglutethimide

1975 • 140 citations

Lesions in the medial forebrain bundle: Relationship between pain sensitivity and telencephalic content of serotonin.

1971 • 136 citations

Insomnia following parachlorophenylalanin in the rat

1968 • 133 citations

Hippocampal mediation of raphe lesion- and PCPA-induced hyperactivity in the rat

1975 • 128 citations

Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles

1976 • 125 citations

Activity, avoidance learning and regional 5-hydroxytryptamine following intra-brain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphe lesions in the rat

1976 • 122 citations

Habituation and sensitization of the rat startle response: Effects of raphe lesions☆

1974 • 121 citations

Kinetics of serotonin accumulation into synaptosomes of rat brain-effects of amphetamine and chloroamphetamines

1973 • 117 citations

Attenuated habituation due to parachlorophenylalanine

1973 • 116 citations

Sleep Patterns of the Monkey and Brain Serotonin Concentration: Effect of p -Chlorophenylalanine

1968 • 114 citations

DEPRESSION OF INTERFERON PRODUCTION AFTER A.L.S. TREATMENT

1969 • 114 citations

Increase of morphine-induced analgesia by stimulation of the nucleus raphe dorsalis

1971 • 112 citations

Serotonin Now: Clinical Implications of Inhibiting Its Synthesis with Para-Chlorophenylalanine

1970 • 111 citations

Serotonin synthesis inhibition and estrous behavior in female rats

1970 • 110 citations

Reversible and irreversible phases of serotonin depletion by 4-chloroamphetamine

1975 • 109 citations

A Possible Role Played by Central Monoamine neurones in Thermo‐Regulation

1967 • 101 citations

Antagonism by methysergide and cinanserin of the antinociceptive action of morphine administered into the periaqueductal gray

1976 • 98 citations

Reserpine Antagonism of Morphine Analgesia in Mice

1954 • 96 citations

Response to electric shock in rats: Effects of selective midbrain raphe lesions

1975 • 90 citations

Effect of 6-hydroxydopamine, 5,6-dihydroxytryptamine and raphe lesions on the antinociceptive actions of morphine in rats

1973 • 89 citations

Brain Amines and Temperature Regulation

1968 • 87 citations

Central action of anorexic agents: Effects of amphetamine and fenfluramine in rats with lateral hypothalamic lesions

1974 • 86 citations

Lesions in the nuclei accumbens septi of the rat: Behavioral and neurochemical effects.

1970 • 85 citations

The effect of biogenic amine modifiers on morphine analgesia and its antagonism by naloxone

1976 • 84 citations

Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons

1971 • 81 citations

Decreased antinociceptive activity of morphine in rats pretreated intraventricularly with 5,6-dihydroxytryptamine, a long-lasting selective depletor of brain serotonin

1973 • 79 citations

Role of monoamines in the anorexigenic actions of fenfluramine, amphetamine and p-chloromethamphetamine

1974 • 77 citations

5-hydroxytryptophan-induced myoclonus: Increased sensitivity to serotonin after intracranial 5,7-dihydroxytryptamine in the adult rat

1976 • 77 citations

Effect of drugs on the tryptamine content of rat tissues.

1973 • 73 citations

Interaction of diet and drugs in the regulation of brain 5-hydroxyindoles and the response to painful electric shock

1976 • 71 citations

Drug induced reversal of brain damage in the rat

1969 • 71 citations

Drugs of Dependence Though Not of Abuse: Fenfluramine and Imipramine

1971 • 70 citations

Antinociceptive action of quipazine: Relation to central serotonergic receptor stimulation

1976 • 68 citations

p-Chloroamphetamine temporal relationship between psychomotor stimulation and metabolism of brain norepinephrine

1970 • 67 citations

Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats

1973 • 67 citations

Biochemical and behavioural alterations following 5,6-dihydroxytryptamine administration into brain

1974 • 66 citations

Changes in feeding behavior after intracerebral injections in the rat

1963 • 66 citations

5,6-dihydroxytryptamine: Suppression of the anorexigenic action of fenfluramine

1973 • 65 citations

Essential Role of Testosterone in the Sexual Stimulation induced by p-Chlorophenylalanine in Male Animals

1970 • 65 citations

p -Chlorophenylalanine Methyl Ester: An Aphrodisiac?

1970 • 63 citations

Sleep Physiology and Pathology: A Symposium.

1970 • 63 citations

Different central mediation of the stimulant effects of amphetamine and its p-chloro analogue

1968 • 60 citations

p-Chloroamphetamine: Behavioral effects of reduced cerebral serotonin in rats

1975 • 60 citations

Experimental studies on alcoholism I. Increased in alcohol preference by 5,6-dihydroxytryptamine and brain acetylcholine

1974 • 60 citations

Correlation between behavioral and biochemical effects of p-chlorophenylalanine in mice and rats

1969 • 59 citations

Chronic Fenfluramine Administration: Some Cerebral Effects

1971 • 55 citations

Depletion of brain serotonin following intraventricular 5,7-dihydroxytryptamine fails to disrupt sleep in the rat

1976 • 55 citations

Effect of cyproheptadine on the electrical activity of the hypothalamic feeding centres

1967 • 55 citations

p-Chloroamphetamine (PCA): Acute and chronic effects on habituation and sensitization of the acoustic startle response in rats

1976 • 54 citations

Withdrawal Depression in Obese Patients after Fenfluramine Treatment

1972 • 54 citations

The Effect of Imipramine and Related Antidepressive Drugs on Estrus Behaviour in Ovariectomised Rats Activated by Progesterone, Reserpine or Tetrabenazine in Combination with Estrogen

1966 • 51 citations

Anatomical specificity as the critical determinant of the interrelationship between raphe lesions and morphine analgesia

1975 • 50 citations

5-Hydroxytryptamine supersensitivity as a new theory of headache and central pain: A clinical pharmacological approach with p-chlorophenylalanine

1973 • 50 citations

Effect of lesions in the medial forebrain bundle on three measures of pain sensitivity and noise-elicited startle.

1973 • 50 citations

Reversal of Pargyline-induced Inhibition of Sexual Behaviour in Male Rats by p-Chlorophenylalanine

1971 • 49 citations

Effect of environmental temperature on the turnover of 5‐hydroxytryptamine in various areas of rat brain

1970 • 49 citations

Effect of phenmetrazine, aminorex and (±) p‐chloramphetamine on the motor activity and turnover rate of brain catecholamines

1971 • 49 citations

Impairment of thermoregulation, food and water intakes in the rat after hypothalamic injections of 5,6-dihydroxytryptamine

1975 • 49 citations

The effect of parachlorophenylalanine (PCPA) on shock-induced fighting behavior in rats

1970 • 48 citations

The effect of 5,6-dihydroxytryptamine on sexual behaviour of male rats

1972 • 46 citations

Serotonin, Norepinephrine, and Fever

1968 • 46 citations

The effect of para-chlorophenylalanine on aversion thresholds and reactivity to foot shock

1972 • 46 citations

Controlled trial of propranolol in intermittent claudication

1975 • 46 citations

Neurochemical correlates of behavior. I. Quantitative measurement of the behavioral effects of the serotonin precursor, 5-hydroxytryptophan.

1961 • 45 citations

Myoclonus after 5‐hydroxytryptophan in rats with lesions of indoleamine neurons in the central nervous system

1976 • 44 citations

Eating, drinking and activity in rats following 5-hydroxytryptophan (5-HTP) administration

1964 • 42 citations

SEROTONIN AND SLEEP IN THE CAT

1973 • 41 citations

Some 5-hydroxytryptamine-like actions of fenfluramine: a comparison with (+)-amphetamine and diethylpropion

1971 • 40 citations

Aralkylamines with different effects on the metabolism of aromatic monoamines.

1966 • 40 citations

The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction

1974 • 39 citations

Depression Following Fenfluramine Withdrawal

1972 • 39 citations

Long-term effects of 5,7-dihydroxytryptamine administered at birth on the development of brain monoamines

1974 • 37 citations

Postural changes, tremor, and myoclonus in the rat immediately following injections of p‐chloroamphetamine

1977 • 36 citations

Differential effects on morphine analgesia and naloxone antagonism by biogenic amine modifiers

1975 • 36 citations

Discussion of Serotonin, Norepinephrine, and Fever

1968 • 35 citations

Effects of p-chloroamphetamine on locomotor activity and brain 5-hydroxyindoles

1976 • 34 citations

Block by LSD of the Increase in Brain Serotonin Turnover induced by Elevated Ambient Temperature

1968 • 34 citations

Long-term effects of 5,7-dihydroxytryptamine on brain monoamines

1974 • 31 citations

Ionic changes in cerebrospinal fluid and feeding, drinking and temperature of sheep

1973 • 31 citations

EEG profiles of fenfluramine, amobarbital and dextroamphetamine in normal volunteers

1971 • 29 citations

Treatment of Tardive Dyskinesia with Lithium Carbonate

1974 • 28 citations

The sleep-dream cycle and brain serotonin

1967 • 27 citations

Fenfluramine and critical flicker frequency

1967 • 27 citations

Effect of blockade of 5-hydroxytryptamine re-uptake on drug-induced antinociception in the rat

1976 • 25 citations

Influence of serotonin upon optic evoked potentials, EEG, and blood pressure of cat

1963 • 25 citations

Forebrain biogenic amine function in high and low active female rats

1970 • 24 citations

Unchanged sensitivity to electric shock in L-tryptophan treated rats

1975 • 23 citations

Effects of para-chlorophenylalanine on food intake in rats

1974 • 22 citations

EFFECTS OF 5,6-DIHYDROXYTRYPTAMINE ON BRAIN MONOAMINE NEURONS IN THE RAT

1973 • 21 citations

p-Chloroamphetamine: Short and long term effects upon shock-elicited

1976 • 21 citations

The effects of chronic fenfluramine administration on behaviour and body weight

1973 • 21 citations

Thermoregulatory deficits in the monkey produced by 5,6-dihydroxytryptamine injected into the hypothalamus

1976 • 20 citations

Female lordotic behavior mediated by monoamines in male rat.

1975 • 19 citations

Structure-activity relationships between meta-substituted N-ethylamphetamines and locomotor activity in mice.

1975 • 18 citations

Effects of three dihydroxylated derivatives of tryptamine on the behavior and on brain amine content in mice

1974 • 16 citations

A collaborative investigation of fenfluramine. Anorexigenic with sedative properties.

1970 • 16 citations

Fenfluramine-induced enhancement of confinement motor activity: An indirect 5-hydroxytryptamine-like action?

1975 • 15 citations

Effects of N-N-Dimethyltryptamine on retention of startle response habituation in the rat

1972 • 15 citations

Abuse of fenfluramine.

1973 • 14 citations

Lack of supersensitivity to L-5-hydroxytryptophan following chronic methysergide treatment

1977 • 11 citations

[PSYCHOANALEPTIC ACTION OF SOME ANOREXIGENIC PHENYLETHYLAMINE DERIVATIVES].

1965 • 10 citations

Properties and Kinetics of Development of Rous Sarcoma Virus-Infected Cells Evidenced by Methylene Blue Staining

1975 • 10 citations

p-Chloroamphetamine: Evidence against a serotonin mediated learning deficit in PKU

1974 • 9 citations

Interactive effect of (±)-fenfluramine and (+)-amphetamine on feeding in rats

1974 • 5 citations