The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction

p-Chlorophenylalanine: a specific depletor of brain serotonin.

1966 • 1,754 citations

Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats

1967 • 911 citations

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

1969 • 645 citations

Antiamphetamine effects following inhibition of tyrosine hydroxylase.

1966 • 445 citations

Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin.

1967 • 418 citations

Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,α-dimethyl-meta-tyramine

1969 • 417 citations

Biochemical and Histochemical Studies on the Effects of Imipramine‐like Drugs and (+)‐Amphetamine on Central and Peripheral Catecholamine Neurons

1966 • 414 citations

Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain

1971 • 405 citations

Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid

1970 • 357 citations

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.

1965 • 348 citations

Role of Catecholamines in the Amphetamine Excitatory Response

1966 • 273 citations

The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons

1971 • 220 citations

Adrenergic Mechanisms and Amphetamine Induced Abnormal Behaviour

1963 • 198 citations

The effect of imipramine of central 5-hydroxytryptamine neurons

1968 • 198 citations

Evidence that the central action of amphetamine is mediated via catecholamines

1966 • 189 citations

Cholinergic Mechanism in Brain inhibiting Amphetamine‐induced Stereotyped Behaviour

1968 • 187 citations

Histochemical studies on the effect of (+)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine

1968 • 173 citations

Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs

1972 • 165 citations

Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in brain

1972 • 161 citations

An investigation of a new instrument to measure motor activity of small animals

1969 • 158 citations

Evidence that the central action of (+)-amphetamine is mediated via catecholamines

1967 • 157 citations

On the significance of central noradrenaline for motor activity: Experiments with a new dopamine β-hydroxylase inhibitor

1969 • 156 citations

Central Effects of Anticholinergic Drugs Measured by the Apomorphine Gnawing Test in Mice

1969 • 155 citations

The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine (clozapine).

1971 • 136 citations

Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines

1969 • 136 citations

Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data?

1966 • 125 citations

Lowering of brain serotonin level by chloramphetamines

1965 • 123 citations

Kinetics of serotonin accumulation into synaptosomes of rat brain-effects of amphetamine and chloroamphetamines

1973 • 117 citations

Demonstration of extraneuronal 5-hydroxytryptamine accumulation in brain following membrane-pump blockade by chlorimipramine

1969 • 114 citations

Intracranial reward and the forebrain's serotonergic mechanism: Studies employing para-chlorophenylalanine and para-chloroamphetamine

1971 • 108 citations

Studies on the action of some psychoactive drugs on central noradrenaline neurones after inhibition of dopamine-β-hydroxylase

1970 • 94 citations

The relative role of storage and synthesis of brain norepinephrine in the psychomotor stimulation evoked by amphetamine or by desipramine and tetrabenazine

1968 • 80 citations

Effect of neuroleptic drugs on central catecholamine turnover assessed using tyrosineand dopamine-β-hydroxylase inhibitors

1972 • 70 citations

On the role of norepinephrine biosynthesis in the central action of amphetamine

1967 • 70 citations

Antagonism of d-amphetamine by alpha-methyl-l-tyrosine: Behavioral evidence for the participation of catecholamine stores and synthesis in the amphetamine stimulant response

1970 • 69 citations

p-Chloroamphetamine temporal relationship between psychomotor stimulation and metabolism of brain norepinephrine

1970 • 67 citations

A time-sample method for measuring general activity and its components.

1958 • 67 citations

P-chloroamphetamine: in vivo investigations on the mechanism of action of the selective depletion of cerebral serotonin.

1970 • 63 citations

Different central mediation of the stimulant effects of amphetamine and its p-chloro analogue

1968 • 60 citations

Correlation between behavioral and biochemical effects of p-chlorophenylalanine in mice and rats

1969 • 59 citations

Acute effects of alpha-methyltyrosine on brain catecholamine levels and on spontaneous and amphetamine-stimulated motor activity in mice.

1969 • 58 citations

The pharmacology of parkinsonism (a review).

1968 • 58 citations

Regional Disappearance of Catecholamines Formed from ¹⁴C‐Tyrosine in Rat Brain: Effect of Synthesis Inhibitors and of Chlorpromazine

1972 • 41 citations

Aralkylamines with different effects on the metabolism of aromatic monoamines.

1966 • 40 citations

Some behavioural effects of variables which influence the ‘general level of activity’ of rats

1970 • 35 citations

Comparative effects of p-chloroamphetamine and amphetamine on metabolism and in vivo release of 3H-norepinephrine in the hypothalamus

1971 • 30 citations

Effect of para-chlorophenylalanine on catecholamine synthesis in rat brain, heart and adrenals

1972 • 27 citations

Integrated effect of psychotropic drugs on the balance of cholino-, adreno-, and serotoninergic processes in the brain as a basis of their gross behavioral and therapeutic actions.

1967 • 20 citations

Studies on the accumulation of O-methylated dopamine and noradrenaline in the rat brain following various neuroleptics, thymoleptics and aceperone.

1972 • 14 citations

Role of catecholamines in the central effects of amphetamine.

1968 • 7 citations

The effect of elantrine, a new anti-Parkinsonism agent, on drug-induced tremor in mice.

1972 • 3 citations