Three-Site Synapsis during Mu DNA Transposition: A Critical Intermediate Preceding Engagement of the Active Site

DNA LOOPING

1992 • 408 citations

Mapping of Deletions and Substitutions in Heteroduplex DNA Molecules of Bacteriophage Lambda by Electron Microscopy

1969 • 408 citations

TRANSPOSITIONAL RECOMBINATION: Mechanistic Insights from Studies of Mu and Other Elements

1992 • 393 citations

[125] Monolayer techniques in electron microscopy of nucleic acid molecules

1968 • 353 citations

Transpososomes: Stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA

1987 • 231 citations

Structure of the bacteriophage Mu transposase core: A common structural motif for DNA transposition and retroviral integration

1995 • 225 citations

Site-specific recognition of the bacteriophage mu ends by the mu a protein

1984 • 207 citations

Overproduction of Escherichia coli integration host factor, a protein with nonidentical subunits

1987 • 205 citations

A defined system for the DNA strand-transfer reaction at the initiation of bacteriophage Mu transposition: protein and DNA substrate requirements.

1985 • 183 citations

Structural aspects of a higher order nucleoprotein complex: induction of an altered DNA structure at the Mu-host junction of the Mu type 1 transpososome.

1991 • 177 citations

Transposition of Mu DNA: Joining of Mu to target DNA can be uncoupled from cleavage at the ends of Mu

1987 • 172 citations

Efficient Mu transposition requires interaction of transposase with a DNA sequence at the Mu operator: Implications for regulation

1989 • 161 citations

Assembly of the active form of the transposase-Mu DNA complex: A critical control point in Mu transposition

1992 • 161 citations

The Hin Invertasome: Protein-Mediated Joining of Distant Recombination Sites at the Enhancer

1990 • 158 citations

Positive and negative regulation of the Mu operator by Mu repressor and Escherichia coli integration host factor.

1986 • 158 citations

Interaction of distinct domains in Mu transposase with Mu DNA ends and an internal transpositional enhancer

1989 • 151 citations

Transposition of Phage Mu DNA

1996 • 150 citations

Role of DNA topology in Mu transposition: Mechanism of sensing the relative orientation of two DNA segments

1986 • 147 citations

Processive recombination by the phage Mu Gin system: Implications for the mechanisms of DNA strand exchange, DNA site alignment, and enhancer action

1990 • 141 citations

Nucleoprotein structures initiating DNA replication, transcription, and site-specific recombination.

1990 • 140 citations

Identification of residues in the Mu transposase essential for catalysis.

1994 • 139 citations

B protein of bacteriophage mu is an ATPase that preferentially stimulates intermolecular DNA strand transfer.

1987 • 122 citations

Site-specific HU binding in the Mu transpososome: conversion of a sequence-independent DNA-binding protein into a chemical nuclease.

1993 • 111 citations

MuB protein allosterically activates strand transfer by the transposase of phage Mu

1991 • 110 citations

A protein factor which reduces the negative supercoiling requirement in the Mu DNA strand transfer reaction is Escherichia coli integration host factor

1989 • 110 citations

Division of labor among monomers within the Mu transposase tetramer

1993 • 108 citations

Action at a distance in Mu DNA transposition: an enhancer-like element is the site of action of supercoiling relief activity by integration host factor (IHF).

1989 • 97 citations

DNA inversions in phages and bacteria

1992 • 97 citations

DNA-protein complexes during attachment-site synapsis in Mu DNA transposition.

1991 • 90 citations

Processive Recombination by Wild-type Gin and an Enhancer-independent Mutant

1994 • 90 citations

Structural domains in phage Mu transposase: identification of the site-specific DNA-binding domain.

1987 • 88 citations

Configuration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots.

1991 • 85 citations

The Mu transpositional enhancer can function in trans: Requirement of the enhancer for synapsis but not strand cleavage

1992 • 79 citations

DNase protection analysis of the stable synaptic complexes involved in Mu transposition.

1991 • 75 citations

A novel class of winged helix–turn–helix protein: the DNA–binding domain of Mu transposase

1994 • 74 citations

Stimulation of the Mu A protein-mediated strand cleavage reaction by the Mu B protein, and the requirement of DNA nicking for stable type 1 transpososome formation. In vitro transposition characteristics of mini-Mu plasmids carrying terminal base pair mutations.

1991 • 72 citations

Analysis of strand exchange and DNA binding of enhancer-independent Gin recombinase mutants.

1993 • 67 citations

Step-arrest Mutants of Phage Mu Transposase

1995 • 67 citations

Mechanism of site-specific DNA inversion in bacteria

1991 • 65 citations

A novel DNA binding and nuclease activity in domain III of Mu transposase: evidence for a catalytic region involved in donor cleavage.

1995 • 56 citations

A domain sharing model for active site assembly within the Mu A tetramer during transposition: the enhancer may specify domain contributions.

1995 • 52 citations

A second high affinity HU binding site in the phage Mu transpososome.

1994 • 51 citations

Assembly of phage Mu transpososomes: Cooperative transitions assisted by protein and DNA scaffolds

1995 • 49 citations

Transposase contacts with mu DNA ends.

1991 • 49 citations

Crucial role for DNA supercoiling in Mu transposition: a kinetic study.

1994 • 46 citations

Role of the A protein-binding sites in the in vitro transposition of mu DNA. A complex circuit of interactions involving the mu ends and the transpositional enhancer.

1992 • 46 citations

Two mutations of phage Mu transposase that affect strand transfer or interactions with B protein lie in distinct polypeptide domains

1991 • 44 citations

Characterization of a region in phage Mu transposase that is involved in interaction with the Mu B protein.

1994 • 39 citations

Enhancer-independent variants of phage Mu transposase: enhancer-specific stimulation of catalytic activity by a partner transposase.

1995 • 23 citations

Electron microscopic analysis of in vitro transposition intermediates of bacteriophage Mu DNA

1986 • 21 citations