Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: Those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

1970 • 2,874 citations

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

1972 • 731 citations

Reactions of the Cyanate Present in Aqueous Urea with Amino Acids and Proteins

1960 • 633 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1989 • 615 citations

Mechanisms of cooperativity and allosteric regulation in proteins

1990 • 514 citations

Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin.

1968 • 513 citations

Three-dimensional fourier synthesis of human deoxyhaemoglobin at 2·5 Å resolution: Refinement of the atomic model

1975 • 431 citations

Isolation and characterization of a new hemoglobin derivative cross-linked between the alpha chains (lysine 99 alpha 1----lysine 99 alpha 2).

1986 • 296 citations

Inhibition of CO2 Combination and Reduction of the Bohr Effect in Haemoglobin chemically modified at its α-Amino Groups

1969 • 248 citations

Differences in the Interaction of 2,3-Diphosphoglycerate with Certain Mammalian Hemoglobins

1971 • 230 citations

The Bohr Effect

1988 • 185 citations

Identification of residues contributing to the Bohr effect of human haemoglobin

1980 • 185 citations

Hemoglobin

1970 • 155 citations

New effectors of human hemoglobin: structure and function

1990 • 129 citations

X-ray diffraction and solution studies of specifically carbamylated human hemoglobin A. Evidence for the location of a proton- and oxygen-linked chloride binding site at valine 1 alpha.

1979 • 128 citations

The effect of potassium chloride on the Bohr effect of human hemoglobin.

1975 • 122 citations

Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors

1991 • 121 citations

Synthesis of Wild Type and Mutant Human Hemoglobins in Saccharomyces cerevisiae

1991 • 120 citations

Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82.

1976 • 119 citations

Determination of the pK values for the alpha-amino groups of human hemoglobin.

1975 • 106 citations

Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats

1992 • 106 citations

Nuclear magnetic resonance quadrupole relaxation studies of chloride binding to human oxy- and deoxyhaemoglobin

1972 • 104 citations

Equilibrium Oxygen Binding to Human Hemoglobin Cross-linked Between the α Chains by Bis(3,5-dibromosalicyl) Fumarate

1989 • 92 citations

T-state hemoglobin with four ligands bound

1988 • 84 citations

Thermodynamic aspects of the co-operativity in four-step oxygenation equilibria of haemoglobin

1979 • 79 citations

Chemical Structures of Pancreatic Ribonuclease and Deoxyribonuclease

1973 • 70 citations

Oxygen-linked binding sites for inorganic anions to hemoglobin.

1980 • 70 citations

Recombinant human sickle hemoglobin expressed in yeast.

1993 • 47 citations

Reactivity of cyanate with valine-1 (alpha) of hemoglobin. A probe of conformational change and anion binding.

1976 • 40 citations

The functional, oxygen-linked chloride binding sites of hemoglobin are contiguous within a channel in the central cavity

1992 • 35 citations

Site-specific modification of hemoglobin by methyl acetyl phosphate

1986 • 31 citations

Methyl Acetyl Phosphate as a Covalent Probe for Anion-binding Sites in Human and Bovine Hemoglobins

1989 • 31 citations

Specifically carboxymethylated hemoglobin as an analogue of carbamino hemoglobin. Solution and X-ray studies of carboxymethylated hemoglobin and X-ray studies of carbamino hemoglobin.

1987 • 30 citations

Rates of carbamylation of specific lysyl residues in bovine alpha-crystallins.

1992 • 28 citations

Comparison of Carboxymethylation Patterns of Harbor Seal and Sperm Whale Myoglobins

1973 • 27 citations

[14] Preparation of hemoglobin carbamylated at specific NH2-terminal residues

1981 • 24 citations

Anion Bohr effect of human hemoglobin

1985 • 11 citations