Opioid peptides modulate immune functions. A review

β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland

1977 • 1,426 citations

On the specificity of naloxone as an opiate antagonist

1979 • 611 citations

Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity

1984 • 611 citations

Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes

1979 • 574 citations

Enhancement of natural cytotoxicity by beta-endorphin.

1983 • 457 citations

Specific Nonopiate Receptors for β-Endorphin

1979 • 412 citations

Regulation of the in vitro antibody response by neuroendocrine hormones

1982 • 405 citations

Corticotropin releasing factor induction of leukocyte-derived immunoreactive ACTH and endorphins

1986 • 361 citations

Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.

1981 • 358 citations

Neural Modulation of Immunity

1985 • 353 citations

Histamine Release during Morphine and Fentanyl Anesthesia

1982 • 309 citations

Psychoneuroimmunology

1982 • 297 citations

Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

1980 • 275 citations

Activation of Mouse T-Helper Cells Induces Abundant Preproenkephalin mRNA Synthesis

1986 • 269 citations

Virus-Induced Corticosterone in Hypophysectomized Mice: A Possible Lymphoid Adrenal Axis

1982 • 266 citations

The narcotic addict as a medical patient

1968 • 242 citations

The Medical Sequelae of Narcotic Addiction

1967 • 236 citations

B-endorphin modulates human immune activity via non-opiate receptor mechanisms

1982 • 234 citations

Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on T lymphocytes.

1980 • 234 citations

Stereoselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes

1980 • 223 citations

Pro-opiomelanocortin messenger ribonucleic acid and posttranslational processing of beta endorphin in spleen macrophages.

1986 • 221 citations

beta-Endorphin augments the cytolytic activity and interferon production of natural killer cells.

1986 • 213 citations

Human leukocyte interferon (HuIFN-α): Potent endorphin-like opioid activity

1981 • 207 citations

Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: Evidence for opiate and nonopiate receptor participation

1984 • 201 citations

Opiate receptors on lymphocytes and platelets in man

1983 • 190 citations

Endorphins stimulate normal human peripheral blood lymphocyte natural killer activity

1984 • 189 citations

Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells.

1987 • 186 citations

The Neuroendocrine Thymus: Coexistence of Oxytocin and Neurophysin in the Human Thymus

1986 • 183 citations

Immunoreactive beta-endorphin in a subpopulation of mouse spleen macrophages.

1984 • 172 citations

Enkephalins as immunomodulators

1983 • 172 citations

Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors

1977 • 168 citations

Reduction of paraquat toxicity by superoxide dismutase

1974 • 165 citations

Newcastle disease virus-infected splenocytes express the proopiomelanocortin gene.

1986 • 160 citations

Endotoxin-Stimulated Opioid Peptide Secretion: Two Secretory Pools and Feedback Control in Vivo

1982 • 149 citations

Comparison of Histamine Release in Human Skin Mast Cells Induced by Morphine, Fentanyl, and Oxymorphone

1985 • 149 citations

Neuroimmunomodulation with enkephalins: Enhancement of human natural killer (NK) cell activity in vitro

1984 • 136 citations

Immunosuppressive effects of chronic morphine treatment in mice

1987 • 133 citations

Bacterial lipopolysaccharide induction of leukocyte-derived corticotropin and endorphins

1985 • 123 citations

The Thymus-Adrenal Connection: Thymosin Has Corticotropin-Releasing Activity in Primates

1983 • 118 citations

High-Molecular-Weight Immunoreactive β-Endorphin in Extracts of Human Placenta Is a Fragment of Immunoglobulin G

1980 • 117 citations

Opioid-mediated suppression of cultured peripheral blood mononuclear cell respiratory burst activity.

1987 • 116 citations

Opioid peptides modulate production of interferon γ by human mononuclear cells

1986 • 112 citations

Endogenous opioid peptides: A guide to structures and terminology

1982 • 109 citations

Lymphoid cells produce an immunoregulatory glucocorticoid increasing factor (GIF) acting through the pituitary gland.

1985 • 107 citations

Effect of alpha-endorphin on the antigen-induced primary antibody response of human blood B cells in vitro.

1986 • 100 citations

Suppression of T lymphocyte chemotactic factor production by the opioid peptides beta-endorphin and met-enkephalin.

1985 • 97 citations

Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

1986 • 95 citations

Coordinate and independent effects of heroin, cocaine, and alcohol abuse on T-cell E-rosette formation and antigenic marker expression

1986 • 93 citations

Binding of naloxone to human T lymphocytes

1987 • 85 citations

The Role of Complement in the Detection of Blood Group Antibodies: Special Reference to the Antiglobulin Test

1961 • 77 citations

Effects of certain abused drugs on hemolysin forming cells

1975 • 74 citations

Mechanistic Implications of the Findings That Opiates and Other Drugs of Abuse Moderate T‐Cell Surface Receptors and Antigenic Markers

1987 • 72 citations

Enhancement of the generation of cytotoxic T cells by endogenous opiates

1986 • 72 citations

Cortisol stimulation by recombinant interferon-α2

1986 • 71 citations

Effect of chronic administration of morphine on primary immune response in mice

1980 • 70 citations

Enkephalins—Enhancement of active T-cell rosettes from lymphoma patients

1983 • 69 citations

Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones.

1987 • 67 citations

Novel processing pathway for proopiomelanocortin in lymphocytes: Endotoxin induction of a new prohormone‐Cleaving enzyme

1987 • 64 citations

Preproenkephalin mRNA in T‐Cells, macrophages, and mast cells

1987 • 64 citations

Immunoreactive Arginine Vasopressin in the Rat Thymus*

1986 • 60 citations

Gastrointestinal regulatory peptides modulate in vitro immune reactions of mouse lymphoid cells

1986 • 58 citations

Enkephalins—Enhancement of active T-cell rosettes from normal volunteers

1984 • 57 citations

The influence of endorphins on peritoneal and mucosal mast cell secretion

1984 • 56 citations

The effect of β-endorphin on natural cytotoxicity and antibody dependent cellular cytotoxicity

1984 • 54 citations

The antimetastatic activity of enkephalin-like peptides

1987 • 53 citations

Β-Endorphin Modulates Immune Functions

1984 • 53 citations

SHAPE CHANGES INDUCED BY BIOLOGICALLY ACTIVE PEPTIDES AND NERVE GROWTH FACTOR IN BLOOD PLATELETS OF RABBITS

1981 • 52 citations

In VivoImmunoreactive Adrenocorticotropin (ACTH) Production by Human Mononuclear Leukocytes from Normal and ACTH-Deficient Individuals*

1987 • 52 citations

Alteration of morphine withdrawal to naloxone by interferon

1983 • 52 citations

Influence of β-endorphin on phytohemagglutinin-induced lymphocyte proliferation and on the expression of mononuclear cell surface antigens in vitro

1985 • 51 citations

Turnover of outer and inner membrane proteins of rat liver mitochondria

1968 • 51 citations

Effects of cloned interferon alpha 2 in normal volunteers: febrile reactions and changes in circulating corticosteroids and trace metals

1983 • 50 citations

Suppression of the induction of delayed hypersensitivity in rats by repetitive morphine treatments

1986 • 50 citations

beta-Endorphin: surface binding and internalization in thymoma cells.

1985 • 49 citations

Influence of Beta-Endorphin, Somatostatin, Substance P and Vasoactive Intestinal Peptide on the Proliferative Response of Human Peripheral Blood T Lymphocytes to Mercuric Chloride

1986 • 49 citations

Dynorphin and Related Opioid Peptides Enhance Tumoricidal Activity Mediated by Murine Peritoneal Macrophages

1987 • 49 citations

Separate populations of opioid containing neurons in the guinea-pig intestine

1985 • 48 citations

Decreased natural and antibody-dependent cellular cytotoxic activities in intravenous drug abusers

1986 • 48 citations

The in vitro effects of endogenous opiates on natural killer cells, antigen-specific cytolytic T cells, and T-cell subsets

1986 • 45 citations

Proenkephalin a-like mRNA in human leukemia leukocytes and CNS-tissues

1986 • 40 citations

Surface features of normal and leukemic lymphocytes as seen by scanning electron microscopy

1975 • 39 citations

Localization of enkephalin immunoreactivity in diverse tissues and cells of the developing and adult rat

1986 • 39 citations

Functional differences between human cutaneous mast cells and basophils: a comparison of morphine-induced histamine release

1986 • 39 citations

Morphine antagonises prostaglandin E1- mediated inhibition of human platelet aggregation

1975 • 38 citations

Evidence that opiate addiction is in part an immune response

1986 • 37 citations

Cell shape of polymorphonuclear leukocytes is influenced by opioids

1985 • 37 citations

Modulation of human concanavalin A-induced lymphocyte proliferative response by physiological concentrations of β-endorphin

1987 • 37 citations

Cyclosporine alters opiate withdrawal in rodents

1985 • 37 citations

Stereospecific opiate binding in living human polymorphonuclear leucocytes

1985 • 36 citations

Suppressive effects of methadone on human blood lymphocytes

1980 • 36 citations

IgE-mediated 14C-serotonin release from rat mast cells modulated by morphine and endorphins

1982 • 36 citations

Enhancement of human lymphocyte natural killing function by non-opioid fragments of β-endorphin

1987 • 35 citations

Endogenous opiates: 1986

1987 • 35 citations

Evidence for an inhibitory role of β-endorphin and other opioids on human total T rosette formation

1984 • 34 citations

The effect of morphine addiction on concanavalin A-mediated blastogenesis

1979 • 33 citations

Does interferon exert its actions through opiate receptors

1984 • 33 citations

Histamine Release Induced by Dynorphin-(1-13) from Rat Mast Cells

1984 • 33 citations

Modulation of human neutrophil adherence by β-endorphin and met-enkephalin

1987 • 32 citations

Plasma extravasation induced by dynorphin-(1–13) in rat skin

1986 • 32 citations

Influence of morphine and naloxone on human peripheral blood T-lymphocytes

1983 • 32 citations

Enkephalins and autoimmunity: Differential effect of methionine‐enkephalin on experimental allergic encephalomyelitis in wistar and lewis rats

1987 • 32 citations

Leu-enkephalin binding to cultured human T lymphocytes

1984 • 31 citations

Modulation of human T-cell suppressor activity by beta endorphin and glycyl-L-glutamine

1986 • 31 citations

Interaction of human beta-endorphin with nonopiate binding sites on the terminal SC5b-9 complex of human complement. Significance of COOH-terminal beta H-endorphin fragments.

1983 • 30 citations

Action of amiodarone on guinea pig heart sodium and potassium activated adenosine triphosphatase

1972 • 30 citations

Opiate antinociception is altered by immunemodification: the effect of inteferon, cyclosporine and radiation-induced immune suppression upon acute and long-term morphine activity

1986 • 29 citations

β-endorphin: Interaction with specific nonopioid binding sites on EL4 thymoma cells

1985 • 28 citations

Plasma Methionine Enkephalin Levels — A Biological Marker for Migraine?

1985 • 27 citations

Thymopoietin and thymopentin enhance the levels of ACTH, β-endorphin and β-lipotropin from rat pituitary cells in vitro

1987 • 27 citations

Evidence of neuro-immunologic interactions: Cyclosporine modifies opiate withdrawal by effects on the brain and immune components

1987 • 27 citations

Effect of two synthetic α-gliadin peptides on lymphocytes in celiac disease: Identification of a novel class of opioid receptors

1987 • 26 citations

The interaction between γ-type endorphins and HLA class I antigens

1986 • 26 citations

Stereospecific opiate binding in human erythrocyte membranes and changes in heroin addicts

1976 • 25 citations

Opiate receptor mediated internalization of I-?-endorphin in human polymorphonuclear leucocytes

1986 • 25 citations

Impaired coupling of naloxone sensitive opiate receptors to adenylate cyclase in PMNLS of aged male subjects

1987 • 25 citations

ROLE OF RECEPTORS AND THE CYTOSKELETON IN REVERSE TRANSFORMATION AND STEROIDOGENESIS INDUCED BY INTERFERON

1980 • 24 citations

Calcium-dependent potassium-stimulated release of neurokinin a and neurokinin B from rat brain regions

1985 • 24 citations

Splenic Leukocytes from Chickens Injected with Salmonella pullorum Antigen Stimulate Production of Corticosteroids by Isolated Adrenal Cells

1985 • 24 citations

The histamine-releasing effect of dynorphin and other peptides possessing Arg-Pro sequences

1985 • 23 citations

Elevation of Circulating ??-Endorphin Levels with Concomitant Depression of Immune Parameters after Traumatic Injury

1986 • 23 citations

The effect of narcotic analgesics on the uptake of 5‐hydroxytryptamine and (—)‐metaraminol by blood platelets

1973 • 22 citations

The role of mast cell disruption in the acute manifestations of the intravenous injection of morphine in dogs

1970 • 22 citations

Modulating Effect of Beta-Endorphin, Somatostatin, Substance P and Vasoactive Intestinal Peptide on the Proliferative Response of Peripheral Blood T Lymphocytes of Nickel-Allergic Patients to Nickel Sulfate

1986 • 22 citations

Corticotropin/β-endorphin immunoreactivity in rat mast cells. Peptide or protease?

1980 • 22 citations

β-endorphin modulation of mitogen-stimulated calcium uptake by rat thymocytes

1987 • 22 citations

Cyclosporine and alpha-interferon do not attenuate morphine withdrawal in rats but do impair thermoregulation

1987 • 20 citations

Neuroimmunomodulation with enkephalins: Effects on thymus and spleen weights in mice

1984 • 20 citations

Enkephalin-binding systems in human plasma

1983 • 20 citations

Plasma histamine and hemodynamic responses following administration of nalbuphine and morphine

1984 • 19 citations

Histamine release from isolated rat mast cells induced by opiates: effect of sterical configuration and calcium

1982 • 18 citations

Do human platelets have opiate receptors?

1980 • 18 citations

Thrombocytosis in the Offspring of Female Mice Receiving dl-Methadone

1980 • 18 citations

The fall in circulating leucocyte and platelets counts after endotoxin: An adrenergic opioid interaction

1981 • 18 citations

Six‐month follow‐up in weanling rats with ventromedial and dorsomedial hypothalamic lesions: Somatic, endocrine, and metabolic changes

1975 • 18 citations

?-Endorphin-like immunoreactivity in plasma cells of the canine colonic mucosa

1980 • 18 citations

Met-enkephalin immunoreactivity in blood platelets

1982 • 18 citations

Validity of the Selective Coefficient of a Behaviour Trait in Hawkmoth Larvae

1970 • 17 citations

Modification of morphine withdrawal: Effect of tuftsin, [Lys4]-tuftsinyltuftsin, tetrapeptide fragment (1−4) of substance P and its amide

1985 • 17 citations

Absence of functional and structural homology of natural and recombinant human leukocyte interferon (IFN-α) with human α-ACTH and β-endorphin

1982 • 17 citations

Beta-endorphin, immunological and biochemical changes in synovial fluid in rheumatic disorders

1986 • 17 citations

Structural comparisons of leukocyte interferon and pro‐opiomelanocortin correlated with immunological similarities

1982 • 16 citations

Binding of radioiodinated human β-endorphin to serum proteins from rats and humans, determined by several methods

1985 • 16 citations

Effects of a Met-Enkephalin Analogue on motility, O₂Consumption, and ATP Content of Human Spermatozoa

1985 • 15 citations

Plasma and red blood cell β-endorphin immunoreactivity in normal and complicated pregnancies: Gestational age variation

1985 • 15 citations

Heroin and Morphine Binding with Human Serum Proteins and Red Blood Cells

1974 • 15 citations

Transport and interaction of drugs in leukocytes

1974 • 14 citations

The Effect of Naloxone and Cyproheptadine on Pulmonary Platelet Trapping, Hypotension, and Platelet Aggregability in Traumatized Dogs

1983 • 14 citations

Thymus peptides interacting with opiate receptors

1985 • 14 citations

Endocrine and Immunological Responses to Acute Stress

1986 • 14 citations

Interactions of morphine with PGE1, isoproterenol, dopamine and aminophylline in rat mast cells; their effect on IgE-mediated14C-serotonin release

1983 • 13 citations

NALOXONE ANTAGONISES EFFECT OF α-GLIADIN ON LEUCOCYTE MIGRATION IN PATIENTS WITH COELIAC DISEASE

1985 • 13 citations

HYPOTHYROIDISM IN CHILDHOOD. IV. THE CREATINE AND CHOLESTEROL RESPONSE TO THYROTROPIC HORMONE1

1941 • 12 citations

Enhanced prostaglandin E₂ and thromboxane B₂ release from resident peritoneal macrophages isolated from morphine‐dependent rats

1987 • 12 citations

Changes in plasma opioid concentrations after physiotherapeutic exercises for arthritic patients

1985 • 12 citations

Serum and Seminal Gonadotropins in Normal and Infertile Men: Correlations with Sperm Count, Prolactinemia, and Seminal Prolactin

1979 • 12 citations

Changes in immunoreactive β-endorphin, methionine-enkephalin and ACTH in bone marrow cells and fluid from leukemic children

1986 • 11 citations

Modulation of the autologous mixed lymphocyte reaction by β-endorphin

1987 • 11 citations

Cytotoxicity of leukocytes from normal and Shigella-susceptible (opium-treated) guinea pigs against virulent Shigella sonnei

1984 • 11 citations

Duration of interferon inhibition following single and multiple injections of morphine

1977 • 10 citations

Beta Endorphin Enhances in Vitro Lymphokine Production in Patients with Squamous Carcinoma of the Head and Neck

1986 • 10 citations

A geraniol derivative — An intermediate in the biosynthesis of squalene by a rat liver enzyme system

1959 • 10 citations

Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats

1987 • 10 citations

Platelet Met-Enkephalin Immunoreactivity and 5–Hydroxytryptamine Concentrations in Migraine Patients: Effects of 5–Hydroxytryptophan, Amitriptyline and Chlorimipramine Treatment

1984 • 10 citations

Immunosuppressive Effects of the Opiopeptins

1986 • 9 citations

Modulation of E-receptor expression on activated T lymphocytes

1986 • 9 citations

Two pools of β-endorphin-like immunoreactivity in blood: Plasma and erythrocytes

1984 • 9 citations

Dual effect of naloxone on blood platelet aggregation and cerebral blood flow in gerbils

1986 • 9 citations

Morphine-Induced Immune Thrombocytopenia

1982 • 9 citations

Single lead acetate insult, testosterone therapy, and erythropoiesis in mice

1977 • 9 citations

Interaction of Met‐Enkephalin with Human Granulocytes

1987 • 8 citations

Pharmacokinetics of Cephanone in Healthy Adult Volunteers

1973 • 8 citations

Endotoxin-induced formation of specific β-endorphin binding sites in human serum

1983 • 7 citations

Thrombocytopenia in heroin users [letter]

1982 • 7 citations

Peptide hormone degradation by a rat mast cell chymase-heparin complex

1981 • 7 citations

?-Endorphin-induced release of 5-hydroxytryptamine from human platelets

1981 • 6 citations

The significance of divalent cations for the release of histamine from isolated rat mast cells

1975 • 6 citations

THE EFFECT OF NON-STEROIDAL ANTIINFLAMMATORY THERAPY ON PLASMA NEUROPEPTIDE CONCENTRATIONS IN PATIENTS WITH OSTEOARTHRITIS

1985 • 5 citations

The effects of agranulocytic and nonagranulocytic drugs in rabbits concurrently treated with busulfan (Myleran) III. Thiouracil, morphine, and penicillin

1960 • 5 citations

Observations on deuterium treatment of a virus-induced mouse leukemia

1964 • 5 citations

Immunosuppression of Rosette-Forming Cells

1976 • 5 citations

Human leukocyte interferon has no structural or biological relationship to corticotropin

1982 • 5 citations

On the quality of man parameters

1965 • 4 citations

Hemostatic Abnormalities in Heroin Addicts

1972 • 4 citations

Effect of morphine on PHA-stimulated human lymphocyte transformation.

1975 • 4 citations

Alteration of the erythrocyte ultrastructure and blood viscosity by morphine

1978 • 4 citations

The inhibition by morphine andd-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism byl-aspartic acid

1987 • 4 citations

The Development of Neuroscience

2002 • 3 citations

Elevation of serum prostagladin E levels following electrical stimulation of the midbrain

1982 • 2 citations

Methionine-emephal in does not alter human platelet aggregatory response

1985 • 2 citations

Untitled

1983 • 2 citations

Production and Regulation of Human T Lymphocyte Chemotactic Factor (LCF)

1985 • 2 citations

Inspiratory versus expiratory efforts in pigeons: A search for selective drug influence

1973 • 1 citations

β-Endorphin administered into the lateral ventricle of the brain causes pulmonary platelet trapping in rabbits

1984 • 1 citations