Immunosuppressive Effects of the Opiopeptins

Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.

1960 • 1,394 citations

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

1966 • 1,274 citations

Psychoneuroendocrine Influences on Immunocompetence and Neoplasia

1981 • 763 citations

THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

1955 • 700 citations

Opioid Peptides Mediate the Suppressive Effect of Stress on Natural Killer Cell Cytotoxicity

1984 • 611 citations

Foot-shock induced stress increases β-endorphin levels in blood but not brain

1977 • 576 citations

Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes

1979 • 574 citations

Intrinsic Mechanisms of Pain Inhibition: Activation by Stress

1984 • 528 citations

Coping and Immunosuppression: Inescapable But Not Escapable Shock Suppresses Lymphocyte Proliferation

1983 • 452 citations

A simple method for the isolation of adrenal chromaffin granules on a large scale

1967 • 439 citations

Specific Nonopiate Receptors for β-Endorphin

1979 • 412 citations

beta-Endorphin enhances lymphocyte proliferative responses.

1982 • 393 citations

Stress-Induced Suppression of Immunity in Adrenalectomized Rats

1983 • 390 citations

Stress-Induced Eating Is Mediated Through Endogenous Opiates

1980 • 296 citations

Stress and Coping Factors Influence Tumor Growth

1979 • 285 citations

Biochemistry of the enkephalins and enkephalin-containing peptides

1983 • 270 citations

Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.

1979 • 251 citations

Tumor Rejection in Rats After Inescapable or Escapable Shock

1982 • 249 citations

B-endorphin modulates human immune activity via non-opiate receptor mechanisms

1982 • 234 citations

Reactions in vivo and in vitro produced by a soluble substance associated with delayed-type hypersensitivity.

1968 • 225 citations

Infection after Cardiovascular Surgery

1968 • 214 citations

Specificity of opioids towards the μ-, δ- and ϵ-opiate receptors

1979 • 194 citations

Comparison of the Effector Cells in Human Spontaneous Cellular Cytotoxicity and Antibody‐Dependent Cellular Cytotoxicity: Differential Sensitivity of Effector Cells to in Vivo and in Vitro Corticosteroids

1978 • 153 citations

Identification of Pro-Opiomelanocortin-Derived Peptides in the Human Adrenal Medulla

1983 • 111 citations

Stress, adaptation, and immunity: Studies in humans

1982 • 106 citations

Induction of the Intermediate Pituitary by Stress: Synthesis and Release of a Nonopioid Form of β-Endorphin

1985 • 105 citations

Association of a Circulating Immunosuppressive Polypeptide with Operative and Accidental Trauma

1977 • 99 citations

Central and Peripheral Endorphins: Basic and Clinical Aspects

1986 • 89 citations

Specific non-opiate binding sites for human β-endorphin on the terminal complex of human complement

1982 • 87 citations

Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands.

1980 • 87 citations

Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists

1983 • 77 citations

Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice

1981 • 74 citations

Mitogens in immunobiology

1976 • 73 citations

[Met5]-enkephalin-like peptides of the adrenal medulla: Release by nerve stimulation and functional implications

1982 • 66 citations

Suppressive serum, suppressor lymphocytes, and death from burns.

1981 • 57 citations

Effect of thermal injury upon the early resistance to infection

1968 • 45 citations

Cell-mediated immune reactions.

1981 • 45 citations

Binding of 3H-β-endorphin in rat brain

1982 • 37 citations

Intact proenkephalin is the major enkephalin-containing peptide produced in rat adrenal glands after denervation.

1984 • 31 citations

In Vitro and In Vivo Effects of β-Endorphin and Met-Enkephalin on Leukocyte Locomotion

1983 • 30 citations

Plasma levels and biochemical characterisation of circulating met-enkephalin in canine endotoxin shock

1984 • 30 citations

Co-release of enkephalins and precursors with catecholamines by the perfused cat adrenal in-situ

1983 • 27 citations

Endogenous opioids may mediate the effects of stress on tumor growth and immune function.

1983 • 21 citations

The C-terminal dipeptide of β-endorphin: A neuropeptide with inhibitory activity

1983 • 11 citations

Enkephalin-induced inhibition of the isolated rat ileum is not blocked by naloxone

1981 • 6 citations

Migration ingibition and cell-mediated immunity. A review.

1971 • 2 citations