Metabolism of leukotrienes
Data up to Jan 2025
Total Citations Per Year
Abstract
References (65)
Enzymatic Basis of Detoxication
1980 • 717 citations
Biochemical actions of hormones
1987 • 588 citations
Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.
1979 • 465 citations
Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources
1980 • 433 citations
Structure of slow-reacting substance of anaphylaxis from guinea-pig lung
1980 • 426 citations
Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4.
1983 • 421 citations
LEUKOTRIENES
1983 • 347 citations
Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B4 from human leukocytes
1981 • 313 citations
Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.
1980 • 301 citations
Identification of the C(6)-S-conjugate of leukotriene a with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity
1980 • 267 citations
Leukotriene A4 hydrolase in human leukocytes. Purification and properties.
1984 • 266 citations
Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes.
1984 • 236 citations
Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes.
1984 • 221 citations
Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase.
1978 • 216 citations
Slow Reacting Substances (SRSs): The structure identification of SRSs from rat basophil leukaemia (RBL-1) cells
1980 • 192 citations
Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.
1982 • 180 citations
Inhibition of leukotriene C and leukotriene D biosynthesis.
1980 • 171 citations
In vivo metabolism of leukotriene C4 in man: Urinary excretion of leukotriene E4
1985 • 151 citations
Metabolism of leukotriene A4 by human erythrocytes. A novel cellular source of leukotriene B4.
1984 • 141 citations
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: A novel, participate glutathione S-transferase
1984 • 121 citations
The inhibition of γ-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(αS, 5S)-α-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)
1980 • 120 citations
Metabolism of leukotriene D by porcine kidney.
1981 • 118 citations
Production of peptide leukotrienes in endotoxin shock
1985 • 118 citations
Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes.
1983 • 108 citations
Distribution and metabolism of 3H-labeled leukotriene C3 in the mouse.
1982 • 98 citations
The myeloperoxidase-dependent metabolism of leukotrienes C4, D4, and E4 to 6-trans-leukotriene B4 diastereoisomers and the subclass-specific S-diastereoisomeric sulfoxides.
1983 • 98 citations
Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils
1985 • 92 citations
Sequential conversion of the glutathionyl side chain of slow reacting substance (SRS) to cysteinyl-glycine and cysteine in rat basophilic leukemia cells stimulated with A-23187
1980 • 82 citations
Metabolism of leukotriene C3 in the guinea pig. Identification of metabolites formed by lung, liver, and kidney.
1981 • 76 citations
Metabolism of leukotriene A4 by an enzyme in blood plasma: a possible leukotactic mechanism.
1983 • 67 citations
The metabolism of leukotrienes in blood plasma studied by high-performance liquid chromatography
1985 • 62 citations
Metabolism of leukotriene B4 in the monkey. Identification of the principal nonvolatile metabolite in the urine
1984 • 62 citations
Characteristics of the uptake of cysteine-containing leukotrienes by isolated hepatocytes
1983 • 61 citations
Leukotriene C4 formation catalyzed by three distinct forms of human cytosolic glutathione transferase
1985 • 60 citations
Leukotriene C4 and D4 formation by particulate enzymes.
1982 • 59 citations
The conversion of leukotriene C4 to isomers of leukotriene B4 by human eosinophil peroxidase
1982 • 57 citations
Rapid invivo metabolism of Leukotriene C3 in the monkey, Macacairus
1981 • 57 citations
Leukotriene B4, C4, D4 and E4 inactivation by hydroxyl radicals
1983 • 56 citations
Uptake and metabolism of leukotriene C3 by isolated rat organs and cells
1982 • 55 citations
Metabolism of leukotrienes B4 and C4 in the isolated perfused rat lung.
1984 • 53 citations
Isolation of anthglutin, an inhibitor of γ-glutamyl transpeptidase from Penicillum oxalicum
1979 • 53 citations
Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases
1984 • 52 citations
Formation of the cysteinyl form of slow reacting substance (leukotriene E4) in human plasma
1980 • 51 citations
Characterization of slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: effect of cysteine on SRS profile.
1980 • 47 citations
Formation of Leukotrienes E3, E4,E5 in Rat Basophilic Leukemia Cells
1981 • 46 citations
The effect of thiols on the immunologic release of slow reacting substance of anaphylaxis. II. Other in vitro and in vivo models.
1976 • 45 citations
Kinetics of the conversion of leukotriene C by γ-glutamyl transpeptidase
1982 • 44 citations
Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase.
1981 • 41 citations
Carbon monoxide inhibits ω-oxidation of leukotriene B4 by human polymorphonuclear leukocytes: Evidence that catabolism of leukotriene B4 is mediated by a cytochrome P-450 enzyme
1984 • 40 citations
Identification of the slow reacting substances from cat paws.
1980 • 38 citations
A review of recent contributions on biologically active products of arachidonate conversion
1982 • 38 citations
A novel leukotriene formed by transpeptidation of leukotriene E
1982 • 38 citations
Enzymatic inactivation of SRS-Cys-Gly (leukotriene D)
1981 • 38 citations
A cell-free preparation of human neutrophils catalyzing NADPH-dependent conversion of leukotriene B4
1984 • 37 citations
Leukotriene B4 metabolism by hepatic cytochrome P-450
1983 • 35 citations
Studies on leukotriene B4 ω-oxidation in human leukocytes
1984 • 35 citations
Leukotriene C 4 Transport by the Choroid Plexus in Vitro
1985 • 34 citations
The effect of thiols on immunologic release of slow reacting substance of anaphylaxis. I. Human lung.
1975 • 33 citations
Leukotriene biosynthesis and metabolism detected by the combined use of HPLC and radioimmunoassay
1984 • 30 citations
Metabolism of leukotriene B4 in hepatic microsomes
1985 • 27 citations
Leukotriene D4 and E4 formation by plasma membrane bound enzymes
1984 • 17 citations
Arylsulfatase inactivation of slow reacting substance. Evidence for proteolysis as a major mechanism when ordinary commercial preparations of the enzyme are used
1980 • 16 citations
Novel leukotrienes and lipoxygenase products from arachidonic acid.
1982 • 11 citations
Evidence for leukotriene A4 as an intermediate in the conversion of 5-HPETE to leukotriene B4 catalyzed by cytochrome P-450
1983 • 11 citations
Transformation of Leukotriene D4 Catalyzed by Lysosomal Cathepsin H of Rat Liver1
1983 • 9 citations