Human Neutrophil Elastase Proteolytically Activates the Platelet Integrin αIIbβ3 through Cleavage of the Carboxyl Terminus of the αIIb Subunit Heavy Chain

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

1979 • 602 citations

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to “integrin”.

1987 • 466 citations

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.

1987 • 428 citations

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1991 • 367 citations

Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets.

1983 • 315 citations

Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain

1981 • 287 citations

Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

1990 • 285 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation

1987 • 257 citations

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen

1989 • 213 citations

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1993 • 188 citations

Clues for Understanding the Structure and Function of a Prototypic Human Integrin: The Platelet Glycoprotein IIb/IIIa Complex

1994 • 182 citations

Cathepsin G is a strong platelet agonist released by neutrophils

1988 • 179 citations

Topography of Ligand-induced Binding Sites, Including a Novel Cation-sensitive Epitope (AP5) at the Amino Terminus, of the Human Integrin β3 Subunit

1995 • 169 citations

Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses.

1986 • 164 citations

Function and Regulation of the β3 Integrins in Hemostasis and Vascular Biology

1995 • 150 citations

Thrombosis and Inflammation as Multicellular Processes: Significance of Cell-Cell Interactions

1995 • 117 citations

Role of neutrophils in the deposition of platelets during acute inflammation.

1983 • 96 citations

Neutrophil Depletion Suppresses 111In-Labeled Platelet Accumulation in Infarcted Myocardium

1985 • 95 citations

Enhancement of cathepsin G-induced platelet activation by leukocyte elastase: consequence for the neutrophil-mediated platelet activation

1993 • 95 citations

Characteristics of the synergistic actions of platelet agonists

1981 • 83 citations

Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G

1990 • 80 citations

Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin).

1986 • 80 citations

Human neutrophil cathepsin G is a potent platelet activator

1994 • 77 citations

Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function.

1987 • 74 citations

Evidence that changes in platelet cyclic AMP levels regulate the fibrinogen receptor on human platelets.

1982 • 70 citations

Characteristics of the synergistic actions of platelet agonists

1981 • 68 citations

Cathepsin G-dependent platelet stimulation by activated polymorphonuclear leukocytes and its inhibition by antiproteinases: role of P-selectin-mediated cell-cell adhesion

1993 • 67 citations

Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa.

1992 • 66 citations

Platelet Activation by Polymorphonuclear Leukocytes: Role of Cathepsin G and P-Selectin

1995 • 58 citations

Peptide sequence information derived by partial acid hydrolysis and matrix-assisted laser desorption/ionization mass spectrometry

1994 • 57 citations

Proteolytic dissection of the isolated platelet fibrinogen receptor, integrin GPIIb/IIIa. Localization of GPIIb and GPIIIa sequences putatively involved in the subunit interface and in intrasubunit and intrachain contacts

1992 • 56 citations

Platelet lntegrins

1995 • 51 citations

Inhibition of fibrinogen receptor-mediated platelet aggregation by heterologous anti-human platelet membrane antibody. Significance of an Mr = 66,000 protein derived from glycoprotein IIIa.

1983 • 51 citations

Exposure of fibrinogen receptors in human platelets by surface proteolysis with elastase.

1986 • 51 citations

Tumor necrosis factor-alpha enhances platelet activation via cathepsin G released from neutrophils.

1991 • 47 citations

Regulation of integrin function and cellular adhesion

1995 • 45 citations

Effect of Neutral Proteases from Blood Leukocytes on Human Platelets

1983 • 45 citations

Bidirectional modulation of platelet and polymorphonuclear leukocyte activities

1993 • 44 citations

A murine monoclonal antibody that blocks fibrinogen binding to normal platelets also inhibits fibrinogen interactions with chymotrypsin- treated platelets

1984 • 38 citations

Neutrophil implications in platelet deposition and vasoconstriction after deep arterial injury by angioplasty in pigs.

1994 • 36 citations

Interference of recombinant eglin C, a proteinase inhibitor extracted from leeches, with neutrophil-mediated platelet activation.

1990 • 34 citations

Intracellular Ca2+ rise in human platelets induced by polymorphonuclear-leucocyte-derived cathepsin G

1992 • 33 citations

Activation of the fibrinogen receptor on human platelets exposed to alpha chymotrypsin

1991 • 33 citations

Neutrophil Elastase Potentiates Cathepsin G-lnduced Platelet Activation

1992 • 31 citations

The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin

1996 • 31 citations

Neutrophil proteinase cathepsin G is proteolytically active on the human platelet glycoprotein Ib-IX receptor: characterization of the cleavage sites within the glycoprotein Ibα subunit

1994 • 29 citations

A Molecular Basis for Affinity Modulation of Fab Ligand Binding to Integrin αIIbβ3

1996 • 28 citations

Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes: a comparison with thrombin

1993 • 25 citations

Serine 752 in the Cytoplasmic Domain of the β3 Integrin Subunit Is not Required for αvβ3 Postreceptor Signaling Events

1996 • 20 citations

Balanced contribution of glycolytic and adenylate pool in supply of metabolic energy in platelets.

1985 • 18 citations

Cell Surface Proteolysis by Serine Proteinases Enhances RGD-Sensitive Melanoma Cell Adhesion on Fibrinogen and Vitronectin

1995 • 10 citations

Synergism between interleukin-8 and tumor necrosis factor-alpha for neutrophil-mediated platelet activation.

1994 • 5 citations

Cathepsin G Activates Platelets in the Presence of Plasma and Stimulates Phosphatidic Acid Formation and Lysosomal Enzyme Release

1993 • 5 citations