MDM2/p53 protein expression in the development of colorectal adenocarcinoma,

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Cancer statistics, 1994

1994 • 1,345 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

1987 • 357 citations

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas.

1993 • 347 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Mdm2: keeping p53 under control

1997 • 267 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Abnormal expression of wild type p53 protein in normal cells of a cancer family patient

1992 • 199 citations

MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation

1997 • 137 citations

MDM2 gene amplification in bone and soft‐tissue tumors: Association with tumor progression in differentiated adipose‐tissue tumors

1995 • 124 citations

p53 tumor-suppressor gene: Clues to molecular carcinogenesis

1997 • 101 citations

MDM2 gene amplification correlates with ring chromosomes in soft tissue tumors

1994 • 99 citations

Agency for Health Care Policy and Research (AHCPR)

2009 • 98 citations

MDM2 and CDK4 gene amplification in Ewing's sarcoma

1995 • 93 citations

p53 and MDM2 in the Development and Progression of Bladder Cancer

1997 • 67 citations

Amplification of multiple regions of chromosome 12, including 12q13–15, in chronic lymphocytic leukaemia

1997 • 50 citations

Inactivation of tumor suppressor genes and deregulation of the c-myc gene in urothelial cancer cell lines

1995 • 47 citations

Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas.

1997 • 46 citations

Update in Gastroenterology

1997 • 37 citations

In situ hybridization and immunohistochemical analysis of cytomegalovirus-associated ileal perforation

1993 • 36 citations

p53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1.

1997 • 18 citations

Expression of mdm2 and p53 in epithelial neoplasms of the colorectum

1998 • 16 citations