Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas

p53 Mutations in Human Cancers

1991 • 8,133 citations

Food, nutrition and the prevention of cancer : a global perspective

1997 • 1,892 citations

Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children

1997 • 1,836 citations

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

1992 • 1,647 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

1997 • 1,345 citations

Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element

2003 • 1,204 citations

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

1994 • 745 citations

Bioactivation of foreign compounds

1985 • 733 citations

Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma

1992 • 723 citations

A Mutator Phenotype in Cancer 1

2001 • 675 citations

A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.

1994 • 668 citations

Emerging molecular markers of cancer

2002 • 662 citations

The toxicology of aflatoxins: human health, veterinary and agricultural significance.

1993 • 586 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.

2001 • 450 citations

Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients.

1999 • 450 citations

Primary prevention of hepatocellular carcinoma

1995 • 443 citations

Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention

2000 • 416 citations

Protective Alterations in Phase 1 and 2 Metabolism of Aflatoxin B1 by Oltipraz in Residents of Qidong, People's Republic of China

1999 • 312 citations

Screening for liver cancer: results of a randomised controlled trial in Qidong, China

2003 • 307 citations

Chlorophyllin intervention reduces aflatoxin–DNA adducts in individuals at high risk for liver cancer

2001 • 301 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan

1996 • 252 citations

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

2001 • 245 citations

Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China

2002 • 227 citations

Green tea: cancer preventive beverage and/or drug

2002 • 215 citations

Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China.

1992 • 212 citations

Ser-249 p53 Mutations in Plasma DNA of Patients With Hepatocellular Carcinoma From The Gambia

2000 • 190 citations

Cancer preventive properties of varieties of Brassica oleracea: a review

1994 • 188 citations

Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.

1986 • 169 citations

The Importance of Using Scientific Principles in the Development of Medicinal Agents from Plants

2001 • 167 citations

Development of Cancer Chemopreventive Agents: Oltipraz as a Paradigm

1999 • 163 citations

Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.

1991 • 162 citations

Specific mutations of hepatitis B virus in plasma predict liver cancer development

2004 • 162 citations

Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma

1994 • 161 citations

Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.

1995 • 154 citations

Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo

2000 • 145 citations

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout

1998 • 134 citations

Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers.

1998 • 130 citations

Modulation of human glutathione S-transferases by botanically defined vegetable diets.

2000 • 128 citations

Excretion of an aflatoxin-guanine adduct in the urine of aflatoxin B1-treated rats.

1981 • 121 citations

Mechanisms of Chlorophyllin Anticarcinogenesis against Aflatoxin B1: Complex Formation with the Carcinogen

1995 • 117 citations

Toxicology of Aflatoxins

2007 • 115 citations

Inhibition of Human Cytochrome P450 Enzymes by 1,2-Dithiole-3-thione, Oltipraz and Its Derivatives, and Sulforaphane

2000 • 115 citations

Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes.

1997 • 115 citations

Approaches to the development and marketing approval of drugs that prevent cancer.

1995 • 113 citations

Vegetable consumption, serum retinol level, and risk of hepatocellular carcinoma.

1995 • 112 citations

Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patients

2003 • 104 citations

Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry.

2001 • 103 citations

The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers

1999 • 99 citations

Chlorophyll derivatives—Their chemistry? commercial preparation and uses

1955 • 91 citations

Antigenotoxic activity of natural chlorophylls

1997 • 88 citations

Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.

1996 • 87 citations

Identification and Characterization of Chlorin e₄ Ethyl Ester in Sera of Individuals Participating in the Chlorophyllin Chemoprevention Trial

2000 • 83 citations

Molecular dosimetry of urinary aflatoxin-N⁷-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by l,2-dithiole-3-thione in rats

1992 • 81 citations

Cancer as an evolutionary process at the cell level: an epidemiological perspective

2003 • 76 citations

Cancer incidence in Conakry, Guinea: first results from the cancer registry 1992–1995

1997 • 75 citations

Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes

1995 • 74 citations

Identification of dithiolethiones with better chemopreventive properties than oltipraz

1998 • 73 citations

Use of Chlorophyllin in the Care of Geriatric Patients

1980 • 69 citations

Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.

1995 • 64 citations

Chlorophyllin Chemoprevention in Trout Initiated by Aflatoxin B1 Bath Treatment: An Evaluation of Reduced Bioavailability vs. Target Organ Protective Mechanisms

1999 • 62 citations

[Primary liver cancer].

1985 • 61 citations

Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer.

1997 • 54 citations

In vivo inhibition of human CYP1A2 activity by oltipraz

2001 • 36 citations

The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers

1999 • 33 citations

Chemoprotective Glucosinolates and Isothiocyanates of Broccoli Sprouts

2001 • 30 citations

Strategies for chemoprotection against aflatoxin-induced liver cancer.

1993 • 28 citations

Reliability of the Uncertified Ballots in the 2000 Presidential Election in Florida

2003 • 24 citations

A Diamond-Shaped Equiponderant Graphical Display of the Effects of Two Categorical Predictors on Continuous Outcomes

2003 • 23 citations

[Universal presence of HBVx gene and its close association with hotspot mutation of p53 gene in hepatocellular carcinoma of prevalent area in China].

1998 • 10 citations

Oltipraz Chemoprevention Trial in Qidong, People’s Republic of China

2001 • 5 citations

Preventive Effects of Drinking Green Tea on Cardiovascular Disease and Cancer

1995 • 5 citations