CSF morphine levels after lumbar intrathecal administration of isobaric and hyperbaric solutions for cancer pain

Endogenous Opioids: Biology and Function

1984 • 1,223 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Pain Relief by Intrathecally Applied Morphine in Man

1979 • 944 citations

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

1977 • 887 citations

Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla

1977 • 863 citations

The Physiology and Pharmacology of Spinal Opiates

1985 • 303 citations

The electron microscopic localization of methionine-enkephalin within the superficial layers (I and II) of the spinal cord

1980 • 234 citations

Continuous low-dose intrathecal morphine administration in the treatment of chronic pain of malignant origin.

1981 • 232 citations

Continuous Low-Dose Intrathecal Morphine Administration in the Treatment of Chronic Pain of Malignant Origin

1982 • 151 citations

Respiratory depression after intrathecal narcotics

1980 • 138 citations

Autoradiographic localization of mu, delta and kappa opioid receptor binding sites in rat and guinea pig spinal cord

1985 • 114 citations

Spinal analgesia: Comparison of the mu agonist morphine and the kappa agonist ethylketazocine

1981 • 112 citations

Opiate receptor binding sites in human spinal cord

1983 • 98 citations

Epidural and intrathecal opiates: Cerebrospinal fluid and plasma profiles in patients with chronic cancer pain

1985 • 89 citations

POSTOPERATIVE SPINAL ANALGESIA WITH MORPHINE

1981 • 83 citations

Spinal fluid kinetics of morphine and heroin

1984 • 80 citations

Determination of morphine and its major metabolite, morphine-3-glucuronide, in blood by high-performane liquid chromatography with electorchemical detection

1979 • 77 citations

Multiple opiate binding sites in rat spinal cord

1982 • 56 citations

Opioid binding sites in different levels of rat spinal cord

1984 • 51 citations

PLASMA CONCENTRATION OF MORPHINE AFTER I.M., EXTRADURAL AND INTRATHECAL ADMINISTRATION

1981 • 42 citations

Spinal versus Intraventricular Chronic Opiate Administration with Implantable Drug Delivery Devices for Cancer Pain

1985 • 39 citations

512. The structure of pseudomorphine

1959 • 34 citations

Afferent basis of nociception and pain: evidence from the characteristics of sensory receptors and their projections to the spinal dorsal horn.

1980 • 33 citations

Kappa opioid receptors in human lumbo-sacral spinal cord

1986 • 33 citations

[Analgesia by intrathecally applied morphine. Pharmacokinetics study and application to intractable pain (author's transl)].

1980 • 33 citations

ACUTE AND CHRONIC EFFECTS OF INTRATHECAL MORPHINE IN MONKEYS

1981 • 32 citations

Treatment of intractable pains in patients with advanced cancer

1984 • 3 citations