The phosphatidate-phosphoinositide cycle: An intracellular messenger system in the action of hormones and neurotransmitters

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

Diglyceride lipase: a pathway for arachidonate release from human platelets.

1979 • 696 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo.

1965 • 389 citations

Phospholipid Metabolism in Stimulated Human Platelets

1980 • 367 citations

Protein Synthesis and Adrenocorticotropin Responsiveness

1963 • 345 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

STUDIES ON THE MECHANISM OF ACTION OF THE ADRENOCORTICOTROPIC HORMONE

1957 • 311 citations

On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase

1977 • 309 citations

Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

1981 • 293 citations

Phospholipids as ionophores.

1976 • 275 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Phosphoinositides and Protein Secretion in Pancreas Slices

1958 • 248 citations

Thrombin-induced hydrolysis of phosphatidylinositol in human platelets.

1980 • 244 citations

The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.

1981 • 228 citations

Pro-Adrenocorticotropin/Endorphin-Derived Peptides: Coordinate Action on Adrenal Steroidogenesis

1980 • 201 citations

Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland

1979 • 193 citations

Muscarinic Receptors in Chromaffin Cell Cultures Mediate Enhanced Phospholipid Labeling but Not Catecholamine Secretion

1981 • 193 citations

Erythrocyte Membrane Polyphosphoinositide Metabolism and the Regulation of Calcium Binding

1972 • 193 citations

Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells.

1980 • 188 citations

Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine

1979 • 181 citations

The role of cyclic AMP in aldosterone production by isolated zona glomerulosa cells.

1979 • 163 citations

The Mechanism of Action of Adrenocorticotropic Hormone

1974 • 162 citations

The Effect of Ether Anaesthesia Stress on Cholesterol‐Side‐Chain Cleavage and Cytochrome P450 in Rat‐Adrenal Mitochondria

1972 • 160 citations

Recent hypotheses regarding the phosphatidylinositol effect

1981 • 156 citations

Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols.

1982 • 149 citations

Differential activation of platelet phospholipases by thrombin and ionophore A23187.

1981 • 145 citations

Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.

1981 • 135 citations

Why is phosphatidylinositol degraded in response to stimulation of certain receptors?

1981 • 135 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by glycogenolytic hormones. Effects of angiotensin, vasopressin, adrenaline, ionophore A23187 and calcium-ion deprivation

1979 • 133 citations

Is phosphatidylinositol really out of the calcium gate?

1982 • 121 citations

EFFECTS OF CALCIUM ON THE POTASSIUM AND SODIUM CONTENT OF RAT ADRENAL GLANDS, ON THE STIMULATION OF STEROID PRODUCTION BY ADENOSINE 3′,5′-MONOPHOSPHATE, AND ON THE RESPONSE OF THE ADRENAL TO SHORT CONTACT WITH ACTH

1960 • 115 citations

Effect of insulin, catecholamines and calcium ions on phospholipid metabolism in isolated white fat-cells

1980 • 111 citations

Insulin acutely increases phospholipids in the phosphatidate-inositide cycle in rat adipose tissue.

1982 • 110 citations

Acetylcholine causes a net decrease in phosphatidylinositol and a net increase in phosphatidic acid in mouse pancreas

1974 • 108 citations

Separation of two forms of cytochrome P450 adrenal cortex mitochondria

1970 • 107 citations

Characterization of a calcium-mediated activation of arachidonic acid turnover in adrenal phospholipids by corticotropin.

1979 • 106 citations

Production of 1,2-diacylglycerol and phosphatidate in human erythrocytes treated with calcium ions and ionophore A23187

1976 • 105 citations

Thyrotropin-Releasing Hormone (TRH) Selectively and Rapidly Stimulates Phosphatidylinositol Turnover in GH Pituitary Cells: A Possible Second Step of TRH Action*

1982 • 105 citations

EFFECT OF ACTH ON ADRENAL MITOCHONDRIAL CYTOCHROME P‐450 IN THE RAT*

1973 • 104 citations

Enhancement of the muscarinic synaptosomal phospholipid labeling effect by the ionophore A23187.

1981 • 101 citations

Adrenocorticotropin acutely increases adrenal polyphosphoinositides.

1979 • 100 citations

Phosphoinositide interconversion: A model for control of Na+ and K+ permeability in the nerve axon membrane

1971 • 100 citations

Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown

1980 • 97 citations

The actions of pancreozymin in pancreas slices and the role of phospholipids in enzyme secretion

1956 • 97 citations

Myo-inositol Lipids

1976 • 94 citations

Phosphatidylcholine vesicle reconstituted cytochrome P-450scc. Role of the membrane in control of activity and spin state of the cytochrome.

1980 • 94 citations

Receptor occupancy dose—response curve suggests that phosphatidyl‐inositol breakdown may be intrinsic to the mechanism of the muscarinic cholinergic receptor

1976 • 92 citations

Are polyphosphoinositides the cycloheximide-sensitive mediator in the steroidogenic actions of adrenocorticotropin and adenosine-3‘,5‘-monophosphate?

1980 • 89 citations

The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments

1975 • 89 citations

On the mechanism whereby ACTH and cyclic AMP increase adrenal polyphosphoinositides. Rapid stimulation of the synthesis of phosphatidic acid and derivatives of CDP - diacylglycerol.

1980 • 87 citations

Cytochrome P-450scc. Cardiolipin as an effector of activity of a mitochondrial cytochrome P-450.

1981 • 86 citations

Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.

1976 • 84 citations

Inter-Relations between the Phospholipids of Rat Pancreatic Islets during Glucose Stimulation and Their Response to Medium Inositol and Tetracaine

1975 • 83 citations

Polyphosphoinositides: Stimulator of Mitochondrial Cholesterol Side Chain Cleavage and Possible Identification as an Adrenocorticotropin-Induced, Cycloheximide-Sensitive, Cytosolic, Steroidogenic Factor*

1980 • 79 citations

Stimulus-Response Coupling at α-Adrenergic Receptors

1978 • 78 citations

Phosphatidylinositol cleavage in lymphocytes. Requirement for calcium ions at a low concentration and effects of other cations

1974 • 77 citations

Phospholipides and the Secretion of Adrenocorticotropin and of Corticosteroids

1958 • 77 citations

The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium-ion-dependent phosphatidylinositol phosphodiesterase of pig brain

1981 • 71 citations

Parathyroid hormone stimulation of renal phosphoinositide metabolism is a cyclic nucleotide-independent effect

1982 • 68 citations

FUNCTIONAL ACTIVITY IN GLANDS AND SYNAPTIC TISSUE AND THE TURNOVER OF PHOSPHATIDYLINOSITOL

1970 • 67 citations

The role of calcium (Ca++) in TSH and dibutyryl 3′5′ cyclic AMP stimulation of thyroid glucose oxidation and phospholipid synthesis

1968 • 66 citations

The mechanism of thyrotrophin action in relation to lipid metabolism in thyroid tissue

1968 • 65 citations

Corticosteroid-Induced Changes in Phospholipid Membranes as Mediators of Their Action*

1980 • 65 citations

A calcium requirement for the phosphatidylinositol response following activation of presynaptic muscarinic receptors

1979 • 63 citations

Adrenocorticotrophin-Induced Changes in the Steroidogenic Activity of Adrenal Cell-Free Preparations^*

1967 • 63 citations

Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.

1980 • 61 citations

Stimulation of Phospholipid Labeling and Steroidogenesis by Luteinizing Hormone in Isolated Bovine Luteal Cells*

1981 • 56 citations

Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta.

1981 • 56 citations

Acetylcholine increases the level of diglyceride in mouse pancreas

1974 • 55 citations

Effects of calcium-antagonistic drugs on the stimulation by carbamoylcholine and histamine of phosphatidylinositol turnover in longitudinal smooth muscle of guinea-pig ileum

1976 • 54 citations

Ca2+-dependent and Ca2+-independent degradation of phosphatidylinositol in rabbit vas deferens

1981 • 52 citations

Parathyroid Hormone and Adenosine-3′,5′-Monophosphate Acutely Increase Phospholipids of the Phosphatidate-Polyphosphoinositide Pathway in Rabbit Kidney Cortex Tubulesin Vitroby a Cycloheximide-Sensitive Process*

1981 • 51 citations

Cyclic Adenosine Monophosphate-stimulated Transport of Amino Acids in Kidney Cortex

1972 • 51 citations

Nuclear magnetic resonance studies of drug-receptor interactions. The binding of epinphrine to isolated mouse liver cells.

1969 • 50 citations

Comparison of Effects of Adrenocorticotropin and Lys-γ₃Melanocyte-Stimulating Hormone on Steroidogenesis, Adenosine 3′,5′-Monophosphate Production, and Phospholipid Metabolism in Rat Adrenal Fasciculata-Reticularis Cells in Vitro*

1983 • 50 citations

Effects of angiotensin-II and potassium on phospholipid metabolism in the adrenal zona glomerulosa.

1981 • 49 citations

Polyphosphorylated glycerolipids mimic adrenocorticotropin-induced stimulation of mitochondrial pregnenolone synthesis

1979 • 48 citations

Potassium and angiotensin II increase the concentrations of phosphatidic acid, phosphatidylinositol, and polyphosphoinositides in rat adrenal capsules in vitro.

1980 • 47 citations

Inhibition of the steroidogenic effect of ACTH and incorporation of amino acid into rat adrenal protein in vitro by chloramphenicol

1964 • 47 citations

A comparison of the effects of phytohaemagglutinin and of calcium ionophore A23187 on the metabolism of glycerolipids in small lymphocytes

1977 • 45 citations

Parathyroid Hormone-Mediated Incorporation of³²P-Orthophosphate Into Phosphatidic Acid and Phosphatidylinositol in Renal Cortical Slices

1976 • 44 citations

RAT LEYDIG CELL PHOSPHOLIPID CONTENT IS INCREASED BY LUTEINIZING HORMONE AND 8-BROMO-CYCLIC AMP

1982 • 43 citations

DIRECT STIMULATION OF PHOSPHATIDYLINOSITOL DEGRADATION BY ADDITION OF VASOPRESSIN TO PURIFIED RAT LIVER PLASMA MEMBRANES

1982 • 41 citations

Aspects of angiotensin action in the adrenal. Key roles for calcium and phosphatidyl inositol.

1982 • 40 citations

The effect of Ca++ omission on the secretion of catecholamines and the incorporation of orthophosphate-32P into nucleotides and phospholipids of bovine adrenal medulla during acetylcholine stimulation.

1969 • 37 citations

Inhibition of the Metabolism of 25-Hydroxycholecalciferol by Actinomycin D and Cycloheximide

1971 • 37 citations

Thyrotropin releasing hormone stimulates metabolism of phosphatidyl inositol in GH₃ cells

1981 • 37 citations

Nerve growth factor induced turnover of phosphatidylinositol in rat superior cervical ganglia

1978 • 37 citations

Production of 1,2-diacylglycerol in human erythrocyte membranes exposed to low concentrations of calcium ions

1976 • 35 citations

Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro

1980 • 30 citations

Metabolism of phospholipids and the characterization of fatty acids in bovine corpus luteum

1968 • 29 citations

Ca2+-Dependent and Ca2+-independent effects of pancreatic secretagogues on phosphatidylinositol metabolism

1982 • 29 citations

Enhanced Phosphatidylinositol Breakdown as a Calcium-Independent Response of Rat Parotid Fragments to Substance P

1978 • 29 citations

Effects of adrenocorticotropin and cycloheximide on adrenal diglyceride kinase

1981 • 29 citations

The effect of corticotropin on phospholipid metabolism in isolated adrenocortical cells

1978 • 27 citations

Subcellular localization of phospholipid changes in response to muscarinic stimulation of perfused bovine adrenal medulla

1982 • 27 citations

Insulin and Its Secretagogues Activate Ca2+-dependent Phosphatidylinositol Breakdown and Amylase Secretion in Rat Pancreas In Vitro

1981 • 25 citations

Phospholipid Metabolism in Cells from Highly Luteinized Rat Ovaries¹

1977 • 24 citations

Adrenocorticotropin and Adenosine 3′,5′-Monophosphate Stimulatede NovoSynthesis of Adrenal Phosphatidic Acid by a Cycloheximide-Sensitive, Ca⁺⁺-Dependent Mechanism*

1981 • 22 citations

Kinetic aspects of cycloheximide-induced reversal of adrenocorticotropin effects on steroidogenesis and adrenal phospholipids in vivo.

1980 • 21 citations

Comparison of changes in inositide and noninositide phospholipids during acute and prolonged ACTH treatment in vivo

1982 • 19 citations

Ca2+-dependent and Ca2+-independent mechanisms for phosphatidylinositol hydrolysis and 32P-labeling during cholinergic stimulation of the rat submaxillary gland in vitro

1982 • 16 citations

Involvement of phosphatidylinositol breakdown in elevation of cytosol Ca2+ by hormones and relationship to prostaglandin formation.

1982 • 16 citations

Insulin and its secretagogues activate Ca2+-dependent phosphatidylinositol breakdown and amylase secretion in rat pancreas in vitro

1981 • 15 citations

Kinetic Aspects of Cycloheximide-Induced Reversal of Adrenocorticotropin Effects on Steroidogenesis and Phospholipid Metabolism in Rat Adrenal Sectionsin Vitro*

1981 • 15 citations

THE PHOSPHATIDATE‐POLYPHOSPHOINOSITIDE CYCLE: ACTIVATION BY PARATHYROID HORMONE AND DIBUTYRYL‐cAMP IN RABBIT KIDNEY CORTEX*

1981 • 14 citations

ACTH activation of glycolysis in the rat adrenal gland

1970 • 14 citations

Aspects of angiotensin action in the adrenal. Key roles for calcium and phosphatidyl inositol

1982 • 13 citations

Effects of dibutyryl cyclic AMP and theophylline on rat pancreatic phospholipids in vitro Ca2+-sensitive decrease in phosphatidylinositol and cycloheximide-sensitive increase in phosphatidic acid

1981 • 9 citations