Role of Growth Factors, Cytokines, and Their Receptors in the Pathogenesis of Psoriasis

Epidermal Growth Factor

1979 • 2,964 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Biochemical characterization of a gamma interferon-inducible cytokine (IP-10).

1987 • 643 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor

1989 • 505 citations

An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis

1978 • 472 citations

The Stimulation of Epidermal Keratinization by a Protein Isolated from the Submaxillary Gland of the Mouse**From the Department of Biochemistry and the Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee.

1963 • 310 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques.

1988 • 231 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Expression of HLA-DR molecules by keratinocytes, and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques.

1986 • 196 citations

Keratinocyte growth regulation by the products of immune cells.

1988 • 172 citations

Decreased Protein Kinase C Activity in Psoriatic Versus Normal Epidermis

1987 • 123 citations

Antiproliferative effects of recombinant alpha- and gamma-interferons on cultured human keratinocytes.

1984 • 114 citations

Phorbol Ester or Epidermal Growth Factor (EGF) Stimulates the Concurrent Accumulation of mRNA for the EGF Receptor and Its Ligand Transforming Growth Factor-α in a Breast Cancer Cell Line

1989 • 110 citations

Psoriatic Epidermal Cells Demonstrate Increased Numbers and Function of Non-Langerhans Antigen-presenting Cells

1989 • 105 citations

Immunologic mechanisms in psoriasis

1988 • 101 citations

Protein tyrosine kinase and protein phosphotyrosine phosphatase in normal and psoriatic skin

1984 • 56 citations

Partial Characterization of Phospholipase C Activity in Normal, Psoriatic Uninvolved, and Lesional Epidermis

1987 • 53 citations

What Does Epidermal Growth Factor Do and How Does It Do It?

1985 • 37 citations

Immunology/Inflammation of the Skin—A 50-Year Perspective

1989 • 31 citations