Biochemical aspects of the phosphoinositide signalling system with special reference to the formation of inositol cyclic phosphates and arachidonic acid and metabolites on agonist stimulation

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver

1985 • 419 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

The role of phosphoinositiees in signal transduction

1986 • 225 citations

PHOSPHATIDYLINOSITOL TURNOVER IN RECEPTOR MECHANISM AND SIGNAL TRANSDUCTION

1985 • 207 citations

The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol

1971 • 177 citations

Phosphoinositide turnover provides a link in stimulus—response coupling

1985 • 175 citations

<scp>d</scp>-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase

1972 • 128 citations

Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

1986 • 105 citations

Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.

1985 • 103 citations

Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase.

1984 • 95 citations

The formation of inositol 1,2-cyclic 4,5-trisphosphate and inositol 1,2-cyclic 4-bisphosphate on stimulation of mouse pancreatic minilobules with carbamylcholine.

1987 • 75 citations

The formation of inositol 1,2-cyclic phosphate on agonist stimulation of phosphoinositide breakdown in mouse pancreatic minilobules. Evidence for direct phosphodiesteratic cleavage of phosphatidylinositol.

1985 • 60 citations

Arachidonic acid stimulates phosphoinositide hydrolysis and human placental lactogen release in an enriched fraction of placental cells.

1985 • 51 citations

Evidence against cyclic GMP as a mediator of the actions of secretagogues on amylase release from guinea-pig pancreas

1980 • 35 citations

A possible role for guanosine 3′,5′-monophosphate in the stimulus-secretion coupling in exocrine pancreas

1978 • 19 citations

Arachidonic acid stimulates 45calcium efflux and hPL release in isolated trophoblast cells

1986 • 18 citations

Preparation of 32P-labeled inositides and their degradation by soluble kidney enzymes

1975 • 17 citations

Effects of amino acids, glucagon, insulin and acetylcholine on cyclic nucleotide metabolism and amylase secretion in isolated mouse pancreatic fragments

1983 • 6 citations