Pluripotent Stem Cells Engrafted into the Normal or Lesioned Adult Rat Spinal Cord Are Restricted to a Glial Lineage

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord

1999 • 1,212 citations

Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis

1996 • 1,209 citations

Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

1997 • 1,206 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

The Adult Rat Hippocampus Contains Primordial Neural Stem Cells

1997 • 1,080 citations

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

1996 • 1,027 citations

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

1995 • 1,014 citations

Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

1999 • 981 citations

Multipotent neural cell lines can engraft and participate in development of mouse cerebellum

1992 • 928 citations

Isolation, Characterization, and use of Stem Cells from the CNS

1995 • 819 citations

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

1998 • 776 citations

In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain

1996 • 757 citations

A Monitored Contusion Model of Spinal Cord Injury in the Rat

1992 • 736 citations

A self-renewing multipotential stem cell in embryonic rat cerebral cortex

1994 • 578 citations

Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain

1999 • 562 citations

Isolation and Cloning of Multipotential Stem Cells from the Embryonic Human CNS and Establishment of Transplantable Human Neural Stem Cell Lines by Epigenetic Stimulation

1999 • 562 citations

Inhibitors of Neurite Growth

1993 • 545 citations

De novo generation of neuronal cells from the adult mouse brain.

1992 • 535 citations

Multipotent Stem/Progenitor Cells with Similar Properties Arise from Two Neurogenic Regions of Adult Human Brain

1999 • 527 citations

Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury.

1995 • 471 citations

Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

1997 • 439 citations

“Global” cell replacement is feasible via neural stem cell transplantation: Evidence from the dysmyelinated shiverer mouse brain

1999 • 394 citations

Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells

1997 • 369 citations

Survival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System

1996 • 314 citations

Molecular and Cellular Approaches to Neural Development

1998 • 300 citations

Neuroepithelial Stem Cells from the Embryonic Spinal Cord: Isolation, Characterization, and Clonal Analysis

1997 • 298 citations

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis

1988 • 296 citations

Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

1998 • 295 citations

Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells

1997 • 287 citations

Reactive astrocytes express the embryonic intermediate neurofilament nestin

1994 • 253 citations

Comparing Deficits Following Excitotoxic and Contusion Injuries in the Thoracic and Lumbar Spinal Cord of the Adult Rat

1999 • 220 citations

Neurotrophic Factors in Central Nervous System Trauma

1995 • 204 citations

Human Neural Stem Cells: Isolation, Expansion and Transplantation

1999 • 203 citations

Immunology of the Nervous System

1983 • 150 citations

Mitogen and Substrate Differentially Affect the Lineage Restriction of Adult Rat Subventricular Zone Neural Precursor Cell Populations

1999 • 145 citations

The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line

1995 • 138 citations

Induction of Eph B3 after Spinal Cord Injury

1999 • 138 citations

Myelination Following Transplantation of EGF-Responsive Neural Stem Cells into a Myelin-Deficient Environment

1997 • 137 citations

Target regulation of neuronal differentiation in a temperature-sensitive cell line derived from medullary raphe

1993 • 136 citations

Leukemia Inhibitory Factor Is Expressed in Astrocytes Following Cortical Brain Injury

1997 • 130 citations

Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination

1998 • 122 citations

Immunology of the Nervous System

1998 • 121 citations

Physiological relevance and functional potential of central nervous system-derived cell lines

1996 • 121 citations

Transplanted neocortical neurons migrate selectively into regions of neuronal degeneration produced by chromophore-targeted laser photolysis

1993 • 117 citations

The Temporal and Spatial Activation of Microglia in Fiber Tracts Undergoing Anterograde and Retrograde Degeneration Following Spinal Cord Lesion

1995 • 111 citations

Mature Oligodendrocytes

1984 • 108 citations

Altered Acidic and Basic Fibroblast Growth Factor Expression Following Spinal Cord Injury

1993 • 106 citations

Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord

1999 • 104 citations

Restricted growth potential of rat neural precursors as compared to mouse

1997 • 103 citations

Regeneration in the spinal cord

1998 • 98 citations

Variable Morphological Differentiation of a Raphé-Derived Neuronal Cell Line Following Transplantation into the Adult Rat CNS

1993 • 91 citations

Remyelination, revascularization, and recovery of function in experimental spinal cord injury.

1993 • 84 citations

Embryonic Neurons Transplanted to Regions of Targeted Photolytic Cell Death in Adult Mouse Somatosensory Cortex Re-form Specific Callosal Projections

1996 • 83 citations

Neural Precursor Differentiation Following Transplantation into Neocortex Is Dependent on Intrinsic Developmental State and Receptor Competence

1999 • 68 citations

Conditionally Immortalized Neural Progenitor Cells Grafted to the Striatum Exhibit Site-Specific Neuronal Differentiation and Establish Connections with the Host Globus Pallidus

1996 • 64 citations

Changes in expression of ciliary neurotrophic factor (CNTF) and CNTF-receptor alpha after spinal cord injury.

1997 • 57 citations

Selective Hippocampal Lesions Differentially Affect the Phenotypic Fate of Transplanted Neuronal Precursor Cells

1996 • 57 citations

Establishment of pure neuronal cultures from fetal rat spinal cord and proliferation of the neuronal precursor cells in the presence of fibroblast growth factor

1991 • 57 citations

Leukaemia inhibitory factor (LIF) production in a mouse model of spinal trauma

1998 • 52 citations

Changes in expression of ciliary neurotrophic factor (CNTF) and CNTF-receptor ? after spinal cord injury

1997 • 50 citations

Increased ciliary neurotrophic factor expression in reactive astrocytes following spinal cord injury in the rat

1998 • 49 citations

Ethical issues in brain-cell transplantation

1991 • 49 citations

Recovery of Locomotion following Transplantation of Monoaminergic Neurons in the Spinal Cord of Paraplegic Rats^a

1998 • 48 citations

Altered differentiation of cns neural progenitor cells after transplantation into the injured adult rat spinal cord*1

1997 • 46 citations

Induction of mature neuronal properties in immortalized neuronal precursor cells following grafting into the neonatal CNS

1996 • 46 citations

Astrocytic Reaction after Graded Spinal Cord Compression in Rats: Immunohistochemical Studies on Glial Fibrillary Acidic Protein and Vimentin

1995 • 38 citations

Oligodendrocyte survival and function in the long-lived strain of the myelin deficient rat

1995 • 35 citations

Chapter 4 Immortalized neural cell lines for CNS transplantation

2000 • 30 citations