Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

The statistical program SYSTAT

1987 • 703 citations

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1992 • 605 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

1994 • 500 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

1987 • 320 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

1993 • 258 citations

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1993 • 225 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

1991 • 208 citations

Identification of P450 enzymes involved in metabolism of verapamil in humans

1993 • 200 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

1989 • 181 citations

The metabolism of DL-[14C]verapamil in man.

1979 • 167 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

1993 • 132 citations

Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs

1994 • 126 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects.

1992 • 90 citations

Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites.

1993 • 84 citations

Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.

1988 • 80 citations

Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.

1990 • 72 citations

In vitro oxidation of oxicam NSAIDs by a human liver cytochrome P450

1992 • 61 citations

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

1987 • 60 citations

Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2

1990 • 54 citations

Near-total Reduction in Verapamil Bioavailability by Rifampin

1988 • 47 citations

Cytochrome P-450 human-2 (P-450IIC9) in Mephenytoin Hydroxylation Polymorphism in Human Livers: Differences in Substrate and Stereoselectivities among Microheterogeneous P-450IIC Species Expressed in Yeasts1

1991 • 24 citations

Effects of chronic phenobarbital on verapamil disposition in humans.

1988 • 20 citations

Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.

1988 • 20 citations