Angiotensin type-2 receptors and cardiovascular function: are angiotensin type-2 receptors protective?

International union of pharmacology. XXIII. The angiotensin II receptors.

2000 • 2,055 citations

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

1991 • 2,017 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

HDL Cholesterol and Protective Factors in Atherosclerosis

2004 • 629 citations

Newly Recognized Components of the Renin-Angiotensin System: Potential Roles in Cardiovascular and Renal Regulation

2003 • 593 citations

Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

1999 • 558 citations

The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.

1997 • 481 citations

Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction.

1995 • 441 citations

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT ₂ ) angiotensin receptor

1999 • 316 citations

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

1996 • 311 citations

Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide

2001 • 256 citations

Protective Role of the Angiotensin AT ₂ Receptor in a Renal Wrap Hypertension Model

1999 • 241 citations

Angiotensin II Type 2 Receptor Is Upregulated in Human Heart With Interstitial Fibrosis, and Cardiac Fibroblasts Are the Major Cell Type for Its Expression

1998 • 241 citations

Evidence for angiotensin II type 2 receptor–mediated cardiac myocyte enlargement during in vivo pressure overload

2000 • 232 citations

Angiotensin AT₂ receptors: cardiovascular hope or hype?

2003 • 228 citations

The intrarenal renin–angiotensin system and diabetic nephropathy

2003 • 217 citations

Angiotensin II Type 2 Receptor–Mediated Vasodilation in Human Coronary Microarteries

2004 • 191 citations

Can Angiotensin II Type 2 Receptors Have Deleterious Effects in Cardiovascular Disease?

2004 • 180 citations

Cardiac Angiotensin II Type 2 Receptor Activates the Kinin/NO System and Inhibits Fibrosis

2003 • 170 citations

Angiotensin Type 2 Receptor Mediates Valsartan-Induced Hypotension in Conscious Rats

2000 • 161 citations

Angiotensin II Type 2 Receptor Overexpression Preserves Left Ventricular Function After Myocardial Infarction

2002 • 152 citations

AT ₂ Receptor-Mediated Relaxation Is Preserved After Long-Term AT ₁ Receptor Blockade

2002 • 147 citations

Angiotensin II Regulation of Collagen Type I Expression in Cardiac Fibroblasts

2004 • 145 citations

Angiotensin Type 2 Receptor-Mediated Hypotension in Angiotensin Type-1 Receptor-Blocked Rats

2001 • 143 citations

Vascular Response to Angiotensin II Is Exaggerated through an Upregulation of AT1 Receptor in AT2 Knockout Mice

1999 • 118 citations

Immunolocalization of Subtype 2 Angiotensin II (AT ₂ ) Receptor Protein in Rat Heart

1998 • 106 citations

AT₂ receptor‐dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions

2002 • 94 citations

Functional role of angiotensin II AT₂ receptor in modulation of AT₁ receptor‐mediated contraction in rat uterine artery: involvement of bradykinin and nitric oxide

2003 • 87 citations

Angiotensin Subtype-2 Receptors Inhibit Renin Biosynthesis and Angiotensin II Formation

2004 • 84 citations

Cardioprotective Role of AT2 Receptor in Postinfarction Left Ventricular Remodeling

2003 • 84 citations

Cardiac Hypertrophy Is Associated With Decreased eNOS Expression in Angiotensin AT ₂ Receptor–Deficient Mice

2003 • 83 citations

Flow-Dependent Dilation Mediated by Endogenous Kinins Requires Angiotensin AT ₂ Receptors

2004 • 79 citations

AT₂ receptor‐mediated vasodilatation is unmasked by AT₁ receptor blockade in conscious SHR

2004 • 78 citations

Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice

2003 • 76 citations

Increased Vasoconstrictor Response of the Mouse Lacking Angiotensin II Type 2 Receptor

1999 • 71 citations

Angiotensin Subtype 1 Receptor (AT₁) Blockade Improves Vasorelaxation in Heart Failure by Up-Regulation of Endothelial Nitric-Oxide Synthase via Activation of the AT₂Receptor

2003 • 68 citations

Up-Regulation of Angiotensin II Type 2 Receptor in Rat Thoracic Aorta by Pressure-Overload

2003 • 67 citations

The pathophysiology of hypertension The importance of angiotensin II in cardiovascular remodeling

1998 • 59 citations

Prevention of Cardiac Hypertrophy by Angiotensin II Type-2 Receptor Gene Transfer

2004 • 58 citations

Stimulation of Cyclic GMP Production via AT ₂ and B ₂ Receptors in the Pressure-Overloaded Aorta After Banding

2004 • 52 citations

Angiotensin receptor subtypes in the uterine artery during ovine pregnancy

1997 • 48 citations

Nitric Oxide Mediates Benefits of Angiotensin II Type 2 Receptor Overexpression During Post-Infarct Remodeling

2004 • 47 citations

Mechanisms Underlying the Endothelium-Independent Relaxation Induced by Angiotensin II in Rat Aorta

2005 • 38 citations

Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice

2004 • 26 citations

Tempol augments angiotensin II-induced AT2 receptor-mediated relaxation in diabetic rat thoracic aorta

2004 • 25 citations

Angiotensin II Type 2 Receptor Inhibits Prorenin Processing in Juxtaglomerular Cells

2003 • 23 citations

TRANSITORY REDUCTION IN ANGIOTENSIN AT₂ RECEPTOR EXPRESSION LEVELS IN POSTINFARCT REMODELLING IN RAT MYOCARDIUM

2004 • 20 citations