The largest prospective warfarin-treated cohort supports genetic forecasting

Haploview: analysis and visualization of LD and haplotype maps

2004 • 14,114 citations

The Structure of Haplotype Blocks in the Human Genome

2002 • 5,744 citations

A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium with Each Other

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Effect ofVKORC1Haplotypes on Transcriptional Regulation and Warfarin Dose

2005 • 1,397 citations

Linkage Disequilibrium in Humans: Models and Data

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Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

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Cell biology :a laboratory handbook.

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Pedigree disequilibrium tests for multilocus haplotypes

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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

2004 • 1,134 citations

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy

2002 • 1,052 citations

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

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Human P450 metabolism of warfarin

1997 • 790 citations

Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation

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Identification of the gene for vitamin K epoxide reductase

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Genetic Determinants of Response to Warfarin during Initial Anticoagulation

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Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

1994 • 500 citations

A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity

2005 • 487 citations

Common VKORC1 and GGCX polymorphisms associated with warfarin dose

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A simple correction for multiple comparisons in interval mapping genome scans

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Association of warfarin dose with genes involved in its action and metabolism

2006 • 393 citations

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans

2006 • 371 citations

CYP2C9 Genotype-guided Warfarin Prescribing Enhances the Efficacy and Safety of Anticoagulation: A Prospective Randomized Controlled Study

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Pharmacogenetics of warfarin: current status and future challenges

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Genetic association between sensitivity to warfarin and expression of CYP2C9*3

1997 • 309 citations

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Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues

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Influence of CYP2C9 and VKORC1 1173C/T Genotype on the Risk of Hemorrhagic Complications in African-American and European-American Patients on Warfarin

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Genetic Modulation of Oral Anticoagulation with Warfarin

2000 • 241 citations

Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population

2005 • 171 citations

Genotypes of vitamin K epoxide reductase, γ-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients

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Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and γ-glutamyl carboxylase) gene variants with warfarin sensitivity

2003 • 160 citations

Combined genetic profiles of components and regulators of the vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin

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The influence of sequence variations in factor VII, γ-glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement

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Warfarin dosing and cytochrome P450 2C9 polymorphisms

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CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy

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γ‐Glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose

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Several-fold increase in risk of overanticoagulation by CYP2C9 mutations

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Incidence and predictors of severe bleeding during warfarin treatment

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Mechanism of action of warfarin. Warfarin and metabolism of vitamin K1

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Warfarin dose related to apolipoprotein E (APOE) genotype

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Use of Genetic and Nongenetic Factors in Warfarin Dosing Algorithms

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APOE genotype makes a small contribution to warfarin dose requirements

2006 • 51 citations

Gamma-glutamyl carboxylase (GGCX) microsatellite and warfarin dosing

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Reply to 'Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10'

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A permutation procedure for the haplotype method for identification of disease‐predisposing variants

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Internet based clinical trial protocols – as applied to a study of warfarin pharmacogenetics

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Single Nucleotide Polymorphism Analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

2006 • 3 citations