Pharmacogenetics of warfarin: regulatory, scientific, and clinical issues

Prevalence of Diagnosed Atrial Fibrillation in Adults

2001 • 6,106 citations

Effect ofVKORC1Haplotypes on Transcriptional Regulation and Warfarin Dose

2005 • 1,397 citations

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

1999 • 1,263 citations

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

1992 • 1,168 citations

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

2004 • 1,134 citations

Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation

2007 • 1,059 citations

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy

2002 • 1,052 citations

Maternal and fetal sequelae of anticoagulation during pregnancy

1980 • 984 citations

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

2005 • 946 citations

Anticoagulant-related bleeding: Clinical epidemiology, prediction, and prevention

1993 • 904 citations

American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy

2003 • 887 citations

Selecting Patients With Atrial Fibrillation for Anticoagulation

2004 • 754 citations

Clinical Impact of Bleeding in Patients Taking Oral Anticoagulant Therapy for Venous Thromboembolism

2003 • 740 citations

Identification of the gene for vitamin K epoxide reductase

2004 • 710 citations

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

1993 • 682 citations

Managing Oral Anticoagulant Therapy

2001 • 581 citations

Common VKORC1 and GGCX polymorphisms associated with warfarin dose

2005 • 470 citations

Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment

2000 • 387 citations

CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet™ systematic review and meta-analysis

2005 • 366 citations

A Multicomponent Intervention To Prevent Major Bleeding Complications in Older Patients Receiving Warfarin

2000 • 365 citations

Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy

1997 • 364 citations

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

1997 • 309 citations

Trends in the prevalence and management of atrial fibrillation in general practice in England and Wales, 1994-1998: analysis of data from the general practice research database

2001 • 263 citations

Clinical Risk Factors and Timing of Recurrent Venous Thromboembolism During the Initial 3 Months of Anticoagulant Therapy

2000 • 262 citations

Interindividual variability in sensitivity to warfarin-Nature or nurture?

2001 • 259 citations

Genetic Modulation of Oral Anticoagulation with Warfarin

2000 • 241 citations

Aging and the Anticoagulant Response to Warfarin Therapy

1992 • 240 citations

Identification of a null allele of CYP2C9 in an African–American exhibiting toxicity to phenytoin

2001 • 237 citations

Risk of Osteoporotic Fracture in Elderly Patients Taking Warfarin

2006 • 221 citations

Major bleeding after hospitalization for deep-venous thrombosis

1999 • 208 citations

Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors

2003 • 193 citations

Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype

2005 • 191 citations

Risk factors for complications of chronic anticoagulation

1994 • 182 citations

Genetic-based dosing in orthopedic patients beginning warfarin therapy

2007 • 177 citations

A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

2006 • 168 citations

Flexible induction dose regimen for warfarin and prediction of maintenance dose.

1984 • 165 citations

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

1998 • 162 citations

Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and γ-glutamyl carboxylase) gene variants with warfarin sensitivity

2003 • 160 citations

Combined genetic profiles of components and regulators of the vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin

2006 • 159 citations

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.

1993 • 139 citations

A C1173T Dimorphism in the VKORC1 Gene Determines Coumarin Sensitivity and Bleeding Risk

2005 • 135 citations

A Multicomponent Intervention To Prevent Major Bleeding Complications in Older Patients Receiving Warfarin

2000 • 104 citations

The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon

2003 • 102 citations

A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism.

1996 • 97 citations

Missense mutations at ALA‐10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy

1997 • 94 citations

The Frequency and Effects of Cytochrome P450 (CYP) 2C9 Polymorphisms in Patients Receiving Warfarin

2002 • 90 citations

Functional impact of CYP2C9*5, CYP2C9*6, CYP2C9*8, and CYP2C9*11 in vivo among black Africans*1

2004 • 87 citations

A comparison of a low-dose warfarin induction regimen with the modified Fennerty regimen in elderly inpatients

2000 • 76 citations

Implications of Cytochrome P450 2C9 Polymorphism on Warfarin Metabolism and Dosing

2001 • 62 citations

Warfarin Therapy for an Octogenarian Who Has Atrial Fibrillation

2001 • 61 citations

Comparison of an age adjusted warfarin loading protocol with empirical dosing and Fennerty's protocol

1999 • 57 citations

Main haplotypes and mutational analysis of vitamin K epoxide reductase (VKORC1) in a Swedish population: a retrospective analysis of case records

2006 • 57 citations

A new regimen for starting warfarin therapy in out‐patients

1998 • 54 citations

Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

2007 • 42 citations

Evaluation of Warfarin Initiation Regimens in Elderly Inpatients

2000 • 31 citations

Initiating and Maintaining Patients on Warfarin Anticoagulation: The Importance of Monitoring

1999 • 30 citations

The genetics of vitamin K antagonists

2004 • 16 citations