Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

A Rating Scale for Mania: Reliability, Validity and Sensitivity

1978 • 8,000 citations

Seasonal Affective Disorder

1984 • 2,272 citations

Manic-Depressive Insanity and Paranoia.

1921 • 1,607 citations

Neural regulation of circadian rhythms.

1979 • 1,417 citations

The Diagnosis of Depressive Syndromes and the Prediction of E.C.T. Response

1965 • 933 citations

Contemporary Animal Learning Theory

1982 • 903 citations

The Pineal Gland: A Neurochemical Transducer

1974 • 872 citations

The psychology of time

1963 • 799 citations

Disrupted 24-hour Patterns of Cortisol Secretion in Psychotic Depression

1973 • 761 citations

Antidepressant and Circadian Phase-Shifting Effects of Light

1987 • 712 citations

Frequency and Amplitude of Gonadotropin-Releasing Hormone Stimulation and Gonadotropin Secretion in the Rhesus Monkey*

1981 • 670 citations

Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment

1981 • 645 citations

Neuroendocrine Regulation in Depression

1976 • 628 citations

Chronic Pain as a Variant of Depressive Disease The Pain-Prone Disorder

1982 • 610 citations

Endogenomorphic Depression

1974 • 582 citations

Neurotransmitter regulation of anterior pituitary hormones.

1985 • 535 citations

Neurotransmitters of the hypothalamic suprachiasmatic nucleus: Immunocytochemical analysis of 25 neuronal antigens

1985 • 534 citations

Overview: toward a dysregulation hypothesis of depression

1985 • 519 citations

Improvement of Depression by REM Sleep Deprivation

1980 • 433 citations

The Stages of Mania

1973 • 415 citations

A possible common mechanism of action of antidepressant treatments

1976 • 410 citations

Bright artificial light treatment of a manic-depressive patient with a seasonal mood cycle

1982 • 387 citations

Circadian timekeeping in health and disease. Part 1. Basic properties of circadian pacemakers.

1983 • 362 citations

Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber.

1975 • 352 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Physiology of the circadian timing system: predictive versus reactive homeostasis

1986 • 335 citations

Growth Hormone and other Responses to Clonidine in Patients with Endogenous Depression

1981 • 300 citations

A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression.

1984 • 295 citations

Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats

1985 • 282 citations

Circadian Rhythm Mechanisms in Affective Illness and in Antidepressant Drug Action

1982 • 254 citations

Pain relief by antidepressants: Possible modes of action

1985 • 242 citations

Cortisol Hypersecretion and Cognitive Impairment in Depression

1984 • 238 citations

Morphine tolerance as habituation.

1985 • 222 citations

Modulation of receptor mechanisms in the CNS: Hyper-and hyposensitivity to catecholamines

1978 • 221 citations

Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies.

1983 • 194 citations

Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons

1982 • 188 citations

Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review

1986 • 188 citations

“Chronic Pain as a Variant of Depressive Disease”

1984 • 183 citations

The use of sodium valproate, carbamazepine and oxcarbazepine in patients with affective disorders

1985 • 181 citations

Switch from Depression to Mania – A Record Study over Decades between 1920 and 1982

1985 • 180 citations

Role of Serotonergic Input in the Regulation of the β-Adrenergic Receptor-Coupled Adenylate Cyclase System

1982 • 176 citations

Partial Sleep Deprivation as Therapy for Depression

1980 • 168 citations

All-night spectral analysis of the sleep EEG in untreated depressives and normal controls

1984 • 165 citations

Nocturnal temperature in affective disorder

1982 • 162 citations

Comparative Studies of Thought Disorders

1987 • 161 citations

Effects of mood and severity on memory processes in depression and mania.

1987 • 154 citations

The Induction of Mania

1982 • 153 citations

Antidepressants in Chronic Pain

1983 • 143 citations

Melatonin, cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test

1985 • 139 citations

Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide

1980 • 137 citations

Dreaming: The Functional State-Shift Hypothesis

1983 • 133 citations

Lithium slows rat circadian activity rhythms

1980 • 130 citations

Life Events and Mania

1987 • 129 citations

Antidepressant drugs can slow or dissociate circadian rhythms

1982 • 128 citations

Daily Rhythms in Adrenal Responsiveness to Adrenocorticotropin Are Determined Primarily by the Time of Feeding in the Rat*

1979 • 123 citations

[Therapy of endogenous depressions using sleep deprivation. Practical and theoretical consequences].

1971 • 119 citations

Circadian and seasonal rhythms in α- and β-adrenergic receptors in the rat brain

1981 • 118 citations

Does dopamine have a role in schizophrenia?

1978 • 115 citations

Calcium antagonists in mania: A double-blind study of verapamil

1986 • 115 citations

Normothymotics, “Mood-Normalizers”

1963 • 113 citations

Analgesia to painful stimuli in affective illness

1979 • 113 citations

Diurnal rhythm of α2-noradrenergic receptors in the paraventricular nucleus and other brain areas: Relation to circulating corticosterone and feeding behavior

1986 • 112 citations

Central Nervous System Distribution of Vasopressin, Oxytocin, and Neurophysin

1981 • 110 citations

Hypotheses concerning the mechanism of action of antidepressant drugs

1984 • 105 citations

Depression, Urinary Free Cortisol Excretion and Lymphocyte Function

1986 • 104 citations

Clocked Cell Cycle Clocks

1981 • 103 citations

Twenty-four-Hour Rhythm of Prolactin in Depressive Patients

1979 • 99 citations

Depression, Elation, and Lithium Carbonate Responses in Manic Patient Subgroups

1974 • 99 citations

A neural theory of circadian rhythms: Split rhythms, after-effects and motivational interactions

1985 • 96 citations

Hypomania and mania after withdrawal of tricyclic antidepressants

1981 • 95 citations

Pathophysiology of “cholinoceptor supersensitivity” in affective disorders

1986 • 90 citations

Dysrhythmia, dysphoria, and depression: The interaction of learned helplessness and circadian dysrhythmia in the pathogenesis of depression.

1988 • 90 citations

Biological suicide research: Outcome and limitations

1986 • 89 citations

TRH-induced TSH response in unipolar, bipolar, and secondary depressions: Possible utility in clinical assessment and differential diagnosis

1980 • 87 citations

Cancer and the Mind

1983 • 86 citations

Evidence that the pathophysiology of depression and the mechanism of action of antidepressant drugs both involve alterations in circadian rhythms.

1982 • 84 citations

I. The 24-hour profile of prolactin in depression

1980 • 82 citations

Circadian Rhythm of Adrenal Cortical Activity in Depression

1968 • 78 citations

Dopamine in manic depressive illness

1985 • 77 citations

Circadian rhythms and their mechanisms

1986 • 76 citations

Antidepressant withdrawal-induced activation (hypomania and mania): Mechanism and theoretical significance

1984 • 75 citations

Circadian rhythms in endogenous depression

1985 • 73 citations

Description and measurement of concentration problems in depressed patients

1985 • 72 citations

Juvenile Delinquents Revisited

1980 • 71 citations

Regulation and function of noradrenaline receptor systems in brainPsychopharmacological aspects

1984 • 70 citations

Manic‐depressive states and daily temperature

1981 • 70 citations

Cancer and Depression: Cancer Presenting with Depressive Illness: An Autoimmune Disease?

1982 • 69 citations

Rapid cycling affective disorders: A clinical review

1985 • 68 citations

Tryptamine, a Substrate for the Serotonin Transporter in Human Platelets, Modifies the Dissociation Kinetics of [³H]Imipramine Binding: Possible Allosteric Interaction

1985 • 65 citations

Twenty‐four‐hour serum levels of TSH in affective disorders

1984 • 63 citations

Ultradian rhythm of growth hormone secretion and sleep in the adult male rat.

1984 • 62 citations

Loss of rat cerebral cortical opiate receptors following chronic desimipramine treatment

1982 • 62 citations

The 24‐hour pattern of serum TSH in patients with endogenous depression

1980 • 62 citations

Depression and cancer: a follow-up study

1979 • 61 citations

Circadian rhythm of [3H]imipramine binding in the rat suprachiasmatic nuclei

1983 • 59 citations

AN INTRAINDIVIDUAL COMPARISON OF PAIN MEASURES AVERAGED EVOKED RESPONSES AND CLINICAL RATINGS DURING DEPRESSION AND AFTER RECOVERY

1974 • 59 citations

Survival and cure of leukemic mice after circadian optimization of treatment with cyclophosphamide and 1-beta-D-arabinofuranosylcytosine.

1977 • 56 citations

MODIFIED AMINE HYPOTHESIS FOR THE ÆTIOLOGY OF AFFECTIVE ILLNESS

1972 • 55 citations

On the origin of early REM episodes in the sleep of depressed patients: A comparison of three hypotheses

1985 • 55 citations

ECT versus chlorpromazine in mania.

1977 • 54 citations

Lithium Carbonate in Affective Disorders

1975 • 53 citations

Dual Effects of Growth Hormone (GH)-Releasing Hormone Isfusion in Normal Men: Somatotroph Desensitization and Increase in Releasable GH*

1986 • 50 citations

Sub-types of bipolar affective disorder with particular regard to bipolar II.

1983 • 48 citations

Binding of a labeled antidepressant to rat brain tissue

1979 • 46 citations

Monoamine transport in depression

1987 • 45 citations

A modern neurobiological concept of vigilance

1982 • 43 citations

The neuroendocrinology of mania

1985 • 41 citations

Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine.

1983 • 40 citations

Circadian rhythm of adrenal cortical activity in depression.

1969 • 40 citations

Physiological interactions of the basic rest - activity cycle of the brain: Pulsatile luteinizing hormone secretion as a model

1986 • 38 citations

Recognition memory in depression.

1987 • 37 citations

Lithium in the treatment of mania

1985 • 36 citations

The arousal model of time of day effects in human performance efficiency.

1982 • 36 citations

Neuroanatomical site of the inhibitory influence of anxiolytic drugs on central serotonergic transmission

1986 • 35 citations

Selective increase in plasma luteinising hormone concentrations in drug free young men with mania.

1985 • 35 citations

Switch from depression to mania, or from mania to depression

1987 • 31 citations

Neurobiologic Dimensions of Depression and Mania

1983 • 31 citations

Tolerance to Shift Work: A Chronobiological Approach1

2015 • 27 citations

High dose naloxone in depression.

1984 • 26 citations

The structure of psychopharmacological revolutions.

1987 • 26 citations

Fast-cycling bipolar disorder induced by withdrawal from long-term treatment with a tricyclic antidepressant

1984 • 26 citations

Pharmacology of new antidepressants

1984 • 25 citations

[Chronobiological aspects of cyclothymia (author's transl)].

1975 • 25 citations

ANTIDEPRESSANT AGENTS AND REVERSAL OF DIURNAL ACTIVITY CYCLES IN RAT

1975 • 24 citations

Relationship between intrinsic activities of agonists in normal and desensitized tissue and agonist-induced loss of beta adrenergic receptors.

1984 • 24 citations

The induction of mania: a natural history study with controls.

1987 • 24 citations

The ability of antidepressant drugs to desensitize β-receptors is inversely correlated with their clinical potency

1984 • 23 citations

Circadian rhythms of finches under bright light: Is self-sustainment a precondition for circadian rhythmicity?

1980 • 22 citations

Chronobiology of Depression

1983 • 21 citations

Neuropsychopharmacology and Biological Rhythms

2015 • 21 citations

Platelet Radioligand Binding and Neuroendocrine Challenge Tests in Depression

2007 • 21 citations

The effect of methadone on the behavioral and neuroendocrine responses of manic patients

1982 • 20 citations

Variations in platelet 5-hydroxytryptamine in control and depressed populations

1986 • 20 citations

Drug therapy of clinical depressions—Current status and implications for research on neuropharmacology of the affective disorders

1972 • 19 citations

Associative factors in the effects of morphine on self-stimulation

1986 • 17 citations

The neurochemistry of mania

1985 • 16 citations

Effects of chronic lithium, clorgyline, imipramine, fluphenazine and constant darkness on the α-melanotropin content and circadian rhythm in rat brain

1982 • 14 citations

Motor Reactivity, Pain Threshold and Effects of Sleep Deprivation in Unipolar Depressives

1981 • 13 citations

Structure and Neural Connections of the Suprachiasmatic Nucleus

1985 • 11 citations

Loss of eye movements abolishes light entrainment of circadian mesolimbic catecholamine excitability: A function for REM?

1982 • 9 citations

Increases in Platelet 5HT Uptake Rates Following Treatment with ???Uptake Inhibiting??? Drugs

1986 • 9 citations

Circadian Rhythms and the Circadian System

2015 • 9 citations

Cortical neurone responsiveness to substance P is enhanced following chronic but not acute administration of desipramine

1983 • 8 citations

Circadian rhythms in cell migration in vitro, and its effect on antigen-induced migration inhibition.

1975 • 8 citations

Hypomania following Cognitive Therapy

1986 • 7 citations

Circadian Studies of Neurotransmitter Receptors

1985 • 6 citations

Desensitization of β-adrenergic receptor-coupled adenylate cyclase activity

1984 • 5 citations