Desensitization of β-adrenergic receptor-coupled adenylate cyclase activity

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.

1978 • 480 citations

GTP-binding proteins in membranes and the control of adenylate cyclase activity.

1977 • 456 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones.

1976 • 238 citations

Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.

1979 • 211 citations

Catecholamine-Induced Alteration in Sedimentation Behavior of Membrane Bound β-Adrenergic Receptors

1980 • 153 citations

A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes.

1980 • 152 citations

Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.

1979 • 142 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors

1979 • 129 citations

Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.

1980 • 118 citations

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

1981 • 96 citations

The requirement of guanine nucleotides for glucagon stimulation of adenylate cyclase in rat liver plasma membranes.

1977 • 93 citations

Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine.

1979 • 59 citations

A possible molecular mechanism for β-receptor desensitization: Experiments and hypotheses

1981 • 13 citations

Prostaglandin E1-induced desensitization of prostaglandin-sensitive adenylate cyclase of cultured mammalian cells

1979 • 9 citations