Mechanism of Action and Biological Profile of HMG CoA Reductase Inhibitors

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 2,673 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Lipid Research Clinics Program

1984 • 837 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering

1984 • 631 citations

Familial Hypercholesterolemia: Identification of a Defect in the Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Associated with Overproduction of Cholesterol

1973 • 442 citations

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Efficacy and long-term adverse effect pattern of lovastatin

1988 • 338 citations

Lipid metabolism and atherosclerosis

1951 • 298 citations

β-hydroxy-β-methylglutaryl coenzyme a reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver

1960 • 289 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

1986 • 261 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

Detection of Familial Hypercholesterolemia by Assaying Functional Low-Density-Lipoprotein Receptors on Lymphocytes

1986 • 109 citations

Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.

1984 • 99 citations

Ultrastructural analysis of crystalloid endoplasmic reticulum in ut-1 cells and its disappearance in response to cholesterol

1983 • 95 citations

Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolemia induced by a wheat starch-casein diet

1983 • 56 citations

Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes.

1988 • 56 citations

Brain and optic system pathology in hypocholesterolemic dogs treated with a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1988 • 44 citations

Structure elucidation of the bioactive metabolites of ML-236B (mevastatin) isolated from dog urine.

1986 • 35 citations

[Lipid metabolism and atherosclerosis].

1963 • 22 citations

Hydroxymethylglutaryl-coenzyme A reductase exhibits graded distribution in normal and mevinolin-treated ileum.

1987 • 12 citations

3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors: A New Class of Cholesterol-Lowering Agents

1987 • 10 citations