Multiple receptor responses: A new concept to describe the relationship between pharmacological effects and pharmacokinetics of a drug: Studies on clonidine in the rat and cat

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine

1979 • 1,136 citations

Fundamentals of Clinical Pharmacokinetics

1975 • 1,035 citations

Fundamentals of clinical pharmacokinetics

1976 • 771 citations

Hypertension: Mechanisms and Management

1978 • 270 citations

Evidence for an α-sympathomimetic component in the effects of catapresan on vasomotor centres: Antagonism by piperoxane

1971 • 268 citations

Pharmacokinetics and concentration‐effect relationships of intravenous and oral clonidine

1977 • 260 citations

Analgesia produced by clonidine in mice and rats

1974 • 190 citations

Clonidine antinociceptive activity: Effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat

1976 • 156 citations

Relationship between the pharmacokinetics and pharmacodynamics of procainamide

1976 • 155 citations

Multiple classes of dopamine receptors in mammalian central nervous system: The involvement of dopamine-sensitive adenylyl cyclase

1978 • 149 citations

Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 115)

1968 • 147 citations

Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155)

1968 • 105 citations

Kinetics of interaction between drugs and biological systems.

1968 • 94 citations

Relation between morphine pharmacokinetics and analgesia

1978 • 90 citations

Morphine-induced inhibition of different pain responses in relation to the regional turnover of rat brain noradrenaline and dopamine

1975 • 69 citations

Drug distribution and pharmacologic effects

1971 • 67 citations

Multicompartment Pharmacokinetic Models and Pharmacologic Effects

1969 • 62 citations

Effects of clonidine on central sympathetic tone

1970 • 59 citations

Proceedings: An increased reactivity in hypertensive animals after prolonged antihypertensive therapy.

1974 • 55 citations

Further similarities between the action of clonidine and a central activation of the depressor baroreceptor reflex

1974 • 54 citations

THE CARDIOVASCULAR EFFECTS OF INTRAVENTRICULAR CLONIDINE AND BAY 1470 IN CONSCIOUS HYPERTENSIVE CATS

1974 • 52 citations

Involvement of alpha-adrenergic receptors at different levels of the central nervous system in the regulation of blood pressure and heart frequency.

1975 • 39 citations

Bioavailability and Pharmacokinetic Analysis of Drug Responding Systems

1978 • 34 citations

Effect of Clonidine on Blood Pressure, Heart Rate and Body Temperature in Conscious Rats

1977 • 31 citations

Theophylline Increased Sensitivity to Nociceptive Stimulation and Regional Turnover of Rat Brain 5‐HT, Noradrenaline and Dopamine ¹

1974 • 25 citations

Pharmacokinetics of clonidine in the rat and cat

1979 • 23 citations

Steady state plasma concentration of clonidine and its relation to the effects on blood pressure in normotensive and hypertensive rats

1979 • 16 citations

Kinetics of Drug Action in Man

1971 • 14 citations

Blood and brain concentration of morphine and its relation to the analgesic activity in mice.

1971 • 8 citations

The potential role of catecholamines in drug induced changes of central pain responses, with special emphasis on morphine effects in the rat

1976 • 7 citations

Studies on the pharmacokinetics of morphine and codeine with emphasis on its relation to analgesia

1977 • 1 citations