D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN)

1974 • 765 citations

PENICILLIN-BINDING PROTEINS AND THE MECHANISM OF ACTION OF BETA-LACTAM ANTIBIOTICS

1983 • 698 citations

Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA

1991 • 640 citations

SIGNAL TRANSDUCTION PATHWAYS INVOLVING PROTEIN PHOSPHORYLATION IN PROKARYOTES

1991 • 512 citations

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147

1992 • 327 citations

Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly

1989 • 280 citations

Specificity of combination between mucopeptide precursors and vancomycin or ristocetin

1969 • 278 citations

The enterococcus: a classic example of the impact of antimicrobial resistance on therapeutic options

1991 • 232 citations

Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity

1991 • 223 citations

Resistance of enterococci to glycopeptides

1990 • 193 citations

Cytoplasmic steps of peptidoglycan synthesis in Escherichia coli

1982 • 191 citations

COMPETITIVE INHIBITION OF ENZYMATIC REACTIONS BY OXAMYCIN

1960 • 174 citations

The Enzymatic Synthesis of D-Alanyl-D-alanine. III. On the Inhibition of D-Alanyl-D-alanine Synthetase by the Antibiotic D-Cycloserine^*

1964 • 173 citations

Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a d-alanine:d-alanine ligase-related protein necessary for vancomycin resistance

1992 • 149 citations

The VANA glycopeptide resistance protein is related to d-alanyl-d-alanine ligase cell wall biosynthesis enzymes

1990 • 141 citations

The Enzymatic Synthesis of d-Alanyl-d-alanine

1962 • 134 citations

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci

1992 • 132 citations

Kinetic and structural analysis of enzyme intermediates: lessons from EPSP synthase

1990 • 131 citations

Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes

1991 • 129 citations

Structural studies on some antibiotics of the vancomycin group, and on the antibiotic-receptor complexes, by proton NMR

1984 • 111 citations

Characterization of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis

1989 • 104 citations

Measurement of internuclear distances in polycrystalline solids. Rotationally enhanced transfer of nuclear spin magnetization

1989 • 102 citations

Studies on the mode of action of vancomycin

1961 • 100 citations

Synergistic killing of vancomycin-resistant enterococci of classes A, B, and C by combinations of vancomycin, penicillin, and gentamicin

1991 • 100 citations

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases

1991 • 96 citations

Two alanine racemase genes in Salmonella typhimurium that differ in structure and function

1983 • 93 citations

Rotational resonance determination of the structure of an enzyme-inhibitor complex: phosphorylation of an (aminoalkyl)phosphinate inhibitor of D-alanyl-D-alanine ligase by ATP

1990 • 84 citations

Mechanism of resistance to vancomycin in Enterococcus faecium D366 and Enterococcus faecalis A256

1990 • 84 citations

Further evidence for overlapping transcriptional units in an Escherichia coli cell envelope-cell division gene cluster: DNA sequence and transcriptional organization of the ddl ftsQ region

1986 • 83 citations

Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147

1992 • 82 citations

Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase.

1990 • 81 citations

Activity of glycopeptides against vancomycin-resistant gram-positive bacteria

1989 • 80 citations

ATP-dependent inactivation and slow binding inhibition of salmonella typhimurium D-alanine: D-alanine ligase (ADP) by aminoalkylphosphinate and aminophosphonate analogs of D-alanine

1988 • 73 citations

Interactions of vancomycin and ristocetin with peptides as a model for protein binding

1984 • 72 citations

Inducible carboxypeptidase activity in vancomycin-resistant enterococci

1992 • 71 citations

Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming)

1988 • 64 citations

Comparison of vancomycin-inducible proteins from four strains of Enterococci

1990 • 37 citations

Binding site of the antibiotic vancomycin for a cell-wall peptide analog

1981 • 32 citations

POTENTIATION OF INHIBITOR ACTION THROUGH DETERMINATION OF REVERSING METABOLITES

1954 • 14 citations

d-alanine-d-alanine ligase (ADP) from Salmonella typhimurium

1989 • 13 citations