Kinetic Analysis of the Interaction between HIV-1 Protease and Inhibitors Using Optical Biosensor Technology

Real-time biospecific interaction analysis using surface plasmon resonance and a sensor chip technology.

1991 • 909 citations

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1969 • 779 citations

Structural biology of HIV 1 1Edited by P. E. Wright

1999 • 452 citations

Human Immunodeficiency Virus

1996 • 399 citations

Surface Plasmon Resonance Detection and Multispot Sensing for Direct Monitoring of Interactions Involving Low-Molecular-Weight Analytes and for Determination of Low Affinities

1995 • 278 citations

Real-Time Competitive Kinetic Analysis of Interactions between Low-Molecular-Weight Ligands in Solution and Surface-Immobilized Receptors

1994 • 208 citations

Cyclic HIV-1 Protease Inhibitors Derived from Mannitol: Synthesis, Inhibitory Potencies, and Computational Predictions of Binding Affinities

1997 • 160 citations

Identification and Optimization of Regeneration Conditions for Affinity-Based Biosensor Assays. A Multivariate Cocktail Approach

1999 • 121 citations

Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase

1999 • 95 citations

Screening of Compounds Interacting with HIV-1 Proteinase Using Optical Biosensor Technology

1998 • 75 citations

Characterization and autoprocessing of precursor and mature forms of human immunodeficiency virus type 1 (HIV 1) protease purified from Escherichia coli

1989 • 64 citations

Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs

1997 • 49 citations

The Dissociation Rate of Unlabelled Dopamine Antagonists and Agonists from the Dopamine-D²Receptor, Application of an Original Filter Method

1984 • 37 citations

An extended pharmacokinetic/pharmacodynamic model describing quantitatively the influence of plasma protein binding, tissue binding, and receptor binding on the potency and time course of action of drugs

1996 • 30 citations

Determination of Kinetic Rate Constants for the Binding of Inhibitors to HIV-1 Protease and for the Association and Dissociation of Active Homodimer

1994 • 26 citations

A convenient synthesis of 1-(S)-[1′-(S)-(t-butyloxycarbonylamino)-2′-phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

1997 • 25 citations

Inhibitor stabilization of human immunodeficiency virus type-2 proteinase dimer formation.

1991 • 19 citations

Kinetic characterization of the interaction of the Z-fragment of protein A with mouse-IgG3 in a volume in chemical space

1999 • 13 citations

Stabilization of HIV Proteinase Dimer by Bound Substrate

1993 • 13 citations