Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice.

Platinum Compounds: a New Class of Potent Antitumour Agents

1969 • 3,785 citations

Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer

1977 • 1,526 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Toxic effects of cis-dichlorodiammineplatinum(II) in man.

1979 • 327 citations

Isolation and Some Properties of Human Metallothionein^*

1966 • 326 citations

Binding of cadmium ions by rat liver and kidney

1972 • 261 citations

Protection by zinc against cadmium toxicity

1972 • 211 citations

Effect of sodium thiosulfate on cis-dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia.

1980 • 171 citations

Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein

1981 • 168 citations

In Vivo and in Vitro binding of platinum to metallothionein

1984 • 107 citations

Cadmium and Zinc Binding in Mammalian Liver and Kidneys

1972 • 106 citations

Comparison of methods for estimating hepatic metallothionein in rats

1977 • 93 citations

cis-platinum: Subcellular distribution and binding to cytosolic ligands

1983 • 83 citations

Clinical pharmacology of high-dose cisplatin

1985 • 65 citations

Improvement in the therapeutic index of cisplatin (NSC 119875) by pharmacologically induced chloruresis in the rat.

1983 • 65 citations

Concentrations of metallothionein and metals in malignant and non-malignant tissues in human liver

1986 • 55 citations

Tumours from a Cell Strain with a High Content of Metallothionein Show Enhanced Resistance against Cis‐Dichlorodiammineplatinum

1984 • 45 citations

Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice

1985 • 44 citations

Effect of selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum in mice inoculated with Ehrlich ascites tumor cell.

1984 • 41 citations

Binding of bismuth in the kidneys of the rate: The role of metallothionein-like proteins

1977 • 41 citations

Modification of the renal toxicity of cis-dichlorodiammineplatinum(II) with furosemide in male F344 rats.

1977 • 32 citations

Interaction of platinum with metallothionein-like ligands in the rat kidney after administration of cis-dichlorodiammine platinum II

1984 • 30 citations

Renal Metal Binding Proteins

1979 • 28 citations

Selenium Efficiently Depressed Toxic Side Effect of Cis-Diamminedichloroplatinum

1984 • 26 citations

"Two route chemotherapy" using cis-diamminedichloro-platinum(II) and its antidote, sodium thiosulfate, for peritoneally disseminated cancer in rats.

1982 • 22 citations

Effect of Copper Pretreatmeut on Toxicity and Antitumor Activity of Cis-Diamminedichloroplatinum in Mice

1985 • 8 citations