The Antiparasitic Moxidectin: Safety, Tolerability, and Pharmacokinetics in Humans

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1994 • 716 citations

Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene

2001 • 424 citations

Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects

2002 • 322 citations

Macrocyclic lactones in antiparasitic therapy

2002 • 268 citations

Onchocerciasis and its ControlOnchocerciasis and its Control, WHO Technical Report Series No. 852, Report of WHO Expert Committee on Onchocerciasis Control, Office of Publications, WHO, Geneva, Switzerland, ISBN 0512-3054

1996 • 176 citations

Reversal of P-glycoprotein-associated multidrug resistance by ivermectin

1997 • 174 citations

The reproductive lifespan of Onchocerca volvulus in West African savanna

1991 • 171 citations

Haemonchus contortus: Selection at a Glutamate-Gated Chloride Channel Gene in Ivermectin- and Moxidectin-Selected Strains

1998 • 166 citations

Immune Responsiveness And The Pathogenesis Of Human Onchocerciasis

1995 • 163 citations

Absence of sperm from the seminal receptacle of female Onchocerca volvulus following multiple doses of ivermectin.

1993 • 155 citations

Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus

1998 • 149 citations

Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin

1992 • 147 citations

Pathogenesis of Onchocercal Keratitis (River Blindness)

1999 • 125 citations

Population biology of human onchocerciasis

1999 • 114 citations

Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds ( Meriones unguiculatus )

1999 • 104 citations

Molecular biology and electrophysiology of glutamategated chloride channels of invertebrates

1996 • 95 citations

Pharmacokinetics and metabolism of avermectins in livestock

1993 • 93 citations

An electrophysiological preparation ofAscaris suumpharyngeal muscle reveals a glutamate-gated chloride channel sensitive to the avermectin analogue, milbemycin D

1996 • 91 citations

Absorption, Tissue Distribution, Metabolism, and Excretion of Moxidectin in Cattle

1994 • 90 citations

The pharmacokinetics of moxidectin after oral and subcutaneous administration to sheep.

1998 • 90 citations

Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of Collies from the northwestern United States

2002 • 75 citations

Effects of Multiple Monthly Doses of Ivermectin on Adult Onchocerca volvulus

1990 • 73 citations

Comparison of the pharmacokinetics of moxidectin (Equest®) and ivermectin (Eqvalan®) in horses

1999 • 60 citations

Infectious Causes of Uveitis in the Developing World

2000 • 60 citations

Safety of moxidectin in avermectin-sensitive Collies

2000 • 59 citations

A glutamate-gated chloride channel subunit from Haemonchus contortus:

2002 • 58 citations

Ivermectin Prophylaxis Against Experimental Onchocerca Volvulus Infection in Chimpanzees

1988 • 50 citations

Onchocerca volvulusandO. lienalis:the microfilaricidal activity of moxidectin compared with that of ivermectinin vitroandin vivo

1996 • 44 citations

Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs

2002 • 41 citations

Moxidectin: Absorption, Tissue Distribution, Excretion, and Biotransformation of 14C-Labeled Moxidectin in Sheep

1994 • 41 citations

Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions

2001 • 36 citations

Respiratory failure attributable to moxidectin intoxication in a dog

1999 • 33 citations

In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

2001 • 29 citations

Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies

2002 • 27 citations

Moxidectin: Metabolic Fate and Blood Pharmacokinetics of ¹⁴C-Labeled Moxidectin in Horses

1997 • 24 citations

Influence of verapamil on the efflux and metabolism of ¹⁴C moxidectin in cultured rat hepatocytes

2001 • 22 citations

The use of macrocyclic lactones to control parasites of humans.

2002 • 5 citations