ENDOTHELIUM‐DERIVED HYPERPOLARIZING FACTOR

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

1994 • 1,704 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Identification of Epoxyeicosatrienoic Acids as Endothelium-Derived Hyperpolarizing Factors

1996 • 1,226 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.

1994 • 819 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Acetylcholine releases endothelium‐derived hyperpolarizing factor and EDRF from rat blood vessels

1988 • 702 citations

cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells

1993 • 609 citations

Characterization of endothelium‐derived hyperpolarizing factor as a cytochrome P450‐derived arachidonic acid metabolite in mammals.

1994 • 430 citations

Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium

1990 • 400 citations

Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP‐sensitive potassium channels.

1995 • 356 citations

Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery

1992 • 356 citations

Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery.

1982 • 345 citations

Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity

1991 • 322 citations

Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats.

1992 • 253 citations

Mechanisms of action of noradrenaline and carbachol on smooth muscle of guinea‐pig anterior mesenteric artery.

1984 • 251 citations

Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle

1992 • 251 citations

Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation

1990 • 239 citations

Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.

1993 • 233 citations

Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin I converting enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors.

1992 • 221 citations

Heterogeneous distribution of endothelium-dependent relaxations resistant to NG-nitro-L-arginine in rats

1992 • 220 citations

Hyperpolarization as a mechanism for endothelium‐dependent relaxations in the porcine coronary artery.

1992 • 210 citations

Some electrical properties of the endothelium‐dependent hyperpolarization recorded from rat arterial smooth muscle cells.

1989 • 209 citations

Activation of K+ channel in vascular smooth muscles by cytochrome P450 metabolites of arachidonic acid

1993 • 196 citations

Display of the characteristics of endothelium‐derived hyperpolarizing factor by a cytochrome P450‐derived arachidonic acid metabolite in the coronary microcirculation

1994 • 189 citations

Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells

1993 • 188 citations

Endothelium‐derived factors and hyperpolarization of the carotid artery of the guinea‐pig

1996 • 174 citations

Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances

1991 • 171 citations

Hyperpolarization and increased free calcium in acetylcholine-stimulated endothelial cells

1988 • 167 citations

Apamin‐sensitive K+ channels mediate an endothelium‐dependent hyperpolarization in rabbit mesenteric arteries.

1995 • 167 citations

Nitric oxide, ACh, and electrical and mechanical properties of canine arterial smooth muscle

1988 • 162 citations

Endothelium-Derived Hyperpolarizing Factor

1990 • 152 citations

Stretch revealed three components in the hyperpolarization of guinea‐pig coronary artery in response to acetylcholine.

1993 • 141 citations

Endothelium‐dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim

1988 • 138 citations

Bidirectional electrical communication between smooth muscle and endothelial cells in the pig coronary artery

1994 • 137 citations

Endothelium-derived Hyperpolarizing Factor and Endothelium-dependent Relaxations

1993 • 126 citations

Characterization of acetylcholine-induced membrane hyperpolarization in endothelial cells.

1992 • 125 citations

ENDOTHELIUM‐DERIVED HYPERPOLARIZING FACTOR

1996 • 124 citations

Electrical responses of smooth muscle cells during cholinergic vasodilation in the rabbit saphenous artery.

1987 • 124 citations

Cytochrome P450‐dependent effects of bradykinin in the rat heart

1995 • 121 citations

Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney

1992 • 121 citations

Endothelium-dependent relaxation and hyperpolarization in aorta from control and renal hypertensive rats.

1992 • 117 citations

Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.

1993 • 114 citations

Effects of inhibitors of EDRF and EDHF on vasoreactivity of perfused rat lungs

1991 • 111 citations

Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries

1990 • 109 citations

Inhibitors of the cytochrome P450‐mono‐oxygenase and endothelium‐dependent hyperpolarizations in the guinea‐pig isolated carotid artery

1996 • 109 citations

Nonendothelial‐derived nitric oxide activates the ATP‐sensitive K⁺ channel of vascular smooth muscle cells

1994 • 106 citations

Electrical properties of resting and acetylcholine‐stimulated endothelium in intact rat aorta.

1993 • 101 citations

Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery

1993 • 101 citations

Two mechanisms mediate relaxation by bradykinin of pig coronary artery: NO-dependent and -independent responses

1991 • 97 citations

Endothelial communication. State of the art lecture.

1988 • 91 citations

Endothelium-Dependent Dilation of Feline Cerebral Arteries: Role of Membrane Potential and Cyclic Nucleotides

1989 • 90 citations

Endothelium-dependent hyperpolarization of smooth muscle cells in rabbit femoral arteries is not mediated by EDRF (nitric oxide)

1988 • 88 citations

Role of membrane potential in endothelium‐dependent relaxation of guinea‐pig coronary arterial smooth muscle.

1995 • 85 citations

Cholinergic modulation of apical Na+ channels in turtle colon: analysis of CDPC-induced fluctuations

1990 • 82 citations

Neither Nitric Oxide nor Nitroglycerin Accounts for All the Characteristics of Endothelially Mediated Vasodilatation of Pig Coronary Arteries

1988 • 82 citations

Release of different relaxing factors by cultured porcine endothelial cells.

1989 • 78 citations

Bradykinin-induced potassium current in cultured bovine aortic endothelial cells

1990 • 76 citations

Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogues of L-arginine

1991 • 76 citations

Evidence that acetylcholine‐mediated hyperpolarization of the rat small mesenteric artery does not involve the K⁺ channel opened by cromakalim

1991 • 74 citations

Hyperpolarization contributes to endothelium-dependent relaxations to acetylcholine in femoral veins of rats

1991 • 72 citations

Endothelial and smooth muscle cells hyperpolarized by bradykinin are not dye coupled

1990 • 69 citations

Effects of the converting enzyme inhibitor cilazaprilat on endothelium-dependent responses.

1991 • 69 citations

Nature of Endothelium-Derived Relaxing Factor: Are There Two Relaxing Mediators?

1987 • 68 citations

Mechanism of action of EDRF on pressurized arteries: effect on K+ conductance.

1989 • 67 citations

Chronic exposure of cultured endothelial cells to eicosapentaenoic acid potentiates the release of endothelium‐derived relaxing factor(s)

1990 • 66 citations

Substance P‐induced relaxation and hyperpolarization in human cerebral arteries

1995 • 63 citations

Calmidazolium, a calmodulin inhibitor, inhibits endothelium‐dependent relaxations resistant to nitro‐<scp>l</scp>‐arginine in the canine coronary artery

1992 • 59 citations

Endothelium‐dependent relaxation and hyperpolarization evoked by bradykinin in canine coronary arteries: enhancement by exercise‐training

1996 • 59 citations

Multiple pathways underlying endothelium‐dependent relaxation in the rabbit isolated femoral artery

1995 • 58 citations

Endothelium‐dependent relaxation and hyperpolarization of canine coronary artery smooth muscles in relation to the electrogenic Na‐K pump

1989 • 53 citations

Ontogeny of cationic amino acid transport systems in rat placenta

1994 • 53 citations

Dye and electrical coupling of endothelial cells in situ

1989 • 53 citations

Smooth muscle cells affect endothelial membrane potential in rat aorta

1994 • 50 citations

Electrophysiological and mechanical effects of substance P and acetylcholine on rabbit aorta.

1988 • 49 citations

Effect of nitro‐L‐arginine on endothelium‐dependent hyperpolarizations and relaxations of pig coronary arteries.

1992 • 45 citations

Canine arteries release two different endothelium-derived relaxing factors

1989 • 44 citations

Characterization of endothelium‐dependent relaxations resistant to nitro‐<scp>l</scp>‐arginine in the porcine coronary artery

1992 • 42 citations

Effect of NG-Monomethyl-l-Arginine on Endothelium-Dependent Relaxation of Human Subcutaneous Resistance Arteries

1990 • 39 citations

Differences in the K⁺‐channels opened by cromakalim, acetylcholine and substance P in rat aorta and porcine coronary artery

1991 • 38 citations

Substance P and Bradykinin Hyperpolarize Pig Coronary Artery Endothelial Cells in Primary Culture

1989 • 37 citations

Endothelium-Derived Hyperpolarizing Factor(s) and the Potentiation of Kinins by Converting Enzyme Inhibitors

1995 • 35 citations

The electrogenic NaK pump does not contribute to endothelium-dependent hyperpolarization in the rabbit ear artery

1988 • 34 citations

Effect of ACh on electrical and mechanical activity in guinea pig coronary arteries

1989 • 33 citations

Bradykinin-Induced, Nω-Nitro-L-Arginine-Insensitive Endothelium-Dependent Relaxation of Porcine Coronary Arteries Is Not Mediated by Bioassayable Relaxing Substances

1992 • 30 citations

Acetylcholine vasodilation of resistance vessels in vivo may not entirely depend on newly synthesized nitric oxide

1991 • 29 citations

Age-Dependent Decrease in Endothelium-Dependent Hyperpolarizations to Endothelin-3 in the Rat Mesenteric Artery

1993 • 27 citations

Different mechanisms of relaxation of pig coronary artery to bradykinin and cromakalim are distinguished by potassium channel blockers.

1992 • 27 citations

Effects on the rabbit coronary artery of LP-805, a new type of releaser of endothelium-derived relaxing factor and a K+ channel opener.

1992 • 19 citations

Nitroarginine-Sensitive and -Insensitive Components of the Endothelium-Dependent Relaxation in the Guinea-Pig Carotid Artery.

1992 • 18 citations

Electrical and Mechanical Effects of Prostacyclin in the Canine Carotid Artery

1987 • 17 citations

Potentiation of Endothelium-Dependent Hyperpolarization to Serotonin by Dietary Intake of NC 020, a Defined Fish Oil, in the Porcine Coronary Artery

1995 • 15 citations