Ecdysone-controlled expression of transgenes

NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY

1998 • 884 citations

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1996 • 858 citations

Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

1999 • 308 citations

Adenovirus-mediated regulable target gene expression in vivo

1999 • 249 citations

Long-term regulated expression of growth hormone in mice after intramuscular gene transfer

1999 • 176 citations

Crystal Structure of the Ligand-binding Domain of the Ultraspiracle Protein USP, the Ortholog of Retinoid X Receptors in Insects

2001 • 173 citations

Ecdysteroid-dependent regulation of genes in mammalian cells by a Drosophila ecdysone receptor and chimeric transactivators.

1992 • 162 citations

Development of a Destabilized Firefly Luciferase Enzyme for Measurement of Gene Expression

2000 • 140 citations

The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation

2001 • 133 citations

Assessment of a microplate-based bioassay for the detection of ecdysteroid-like or antiecdysteroid activities

1993 • 127 citations

Identification of ligands and coligands for the ecdysone-regulated gene switch

2000 • 116 citations

The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation

2001 • 106 citations

Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs

1998 • 104 citations

High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor

1998 • 97 citations

Stringent Control of Gene ExpressionIn Vivoby Using Novel Doxycycline-DependentTrans-Activators

2002 • 94 citations

An extensive ecdysteroid CoMFA.

1999 • 92 citations

Adenovirus-Mediated Inducible Gene Expression in Vivo by a Hybrid Ecdysone Receptor

2000 • 91 citations

Adenovirus-mediated tissue-targeted expression of a caspase-9-based artificial death switch for the treatment of prostate cancer.

2001 • 91 citations

Controlling mammalian gene expression with small molecules

1997 • 87 citations

26-[125I]iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors.

1988 • 87 citations

Conditional gene targeting for cancer gene therapy

2001 • 75 citations

A new model for 20‐hydroxyecdysone and dibenzoylhydrazine binding: A homology modeling and docking approach

2000 • 75 citations

Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer

2000 • 74 citations

Ecdysteroid receptor and ultraspiracle from Chironomus tentans (Insecta) are phosphoproteins and are regulated differently by molting hormone

1998 • 71 citations

Insect hormones in vertebrates: Anabolic effects of 20-hydroxyecdysone in Japanese quail

1996 • 69 citations

Inducible control of gene expression: prospects for gene therapy

1998 • 68 citations

RXRα overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRα-null fetuses

2000 • 63 citations

Inhibition of [3H]ponasterone A binding by ecdysone agonists in the intact Kc cell line

2002 • 60 citations

Random mutagenesis of the substrate-binding site of a serine protease can generate enzymes with increased activities and altered primary specificities

1993 • 59 citations

Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors.

2001 • 56 citations

Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor

2001 • 55 citations

Sustained mammary gland‐directed, ponasterone A‐inducible expression in transgenic mice

2000 • 53 citations

Creation of ecdysone receptor chimeras in plants for controlled regulation of gene expression

1999 • 45 citations

A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain

2001 • 43 citations

The ecdysone receptor puzzle

1999 • 38 citations

Transcriptional activity of Drosophila melanogaster ecdysone receptor isoforms and ultraspiracle in Saccharomyces cerevisiae

2000 • 38 citations

Engineering Orthogonal Ligand−Receptor Pairs from “Near Drugs”

2001 • 36 citations

Enhanced animal growth via ligand regulated GHRH myogenic injectable vectors

2002 • 35 citations

Evaluation of the tetracycline‐ and ecdysone‐inducible systems for expression of neurotransmitter receptors in mammalian cells

2001 • 35 citations

Alterations in rat lipid metabolism following ecdysterone treatment

1985 • 33 citations

Study of excretion of ecdysterone in human urine

2001 • 32 citations

20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation

1999 • 29 citations

Characteristics of the Action of Ecdysones on Drosophila Imaginal Discs Cultured in Vitro

1976 • 29 citations

Inducible expression and pharmacology of the human excitatory amino acid transporter 2 subtype of L‐glutamate transporter

1999 • 28 citations

Bax-Induced Apoptosis as a Novel Gene Therapy Approach for Carcinoma of the Cervix

2001 • 28 citations

Glucocorticoid Receptor-Interacting Protein-1 and Receptor-Associated Coactivator-3 Differentially Interact with the Vitamin D Receptor (VDR) and Regulate VDR-Retinoid X Receptor Transcriptional Cross-Talk*

2001 • 28 citations

Excretion and metabolism of injected ecdysone in the white mouse

1988 • 26 citations

Targeted gene regulation and gene ablation

2001 • 25 citations

Reconstruction of Ligand-Dependent Transactivation ofChoristoneura fumiferanaEcdysone Receptor in Yeast

2001 • 24 citations

Ecdysterone induces acetylcholinesterase in mammalian brain

1984 • 24 citations

Bicistronic Expression of Ecdysone-Inducible Receptors in Mammalian Cells

2001 • 23 citations

The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells.

2001 • 23 citations

Cell-Specific Ecdysone-Inducible Expression of FLP Recombinase in Mammalian Cells

1998 • 22 citations

Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts

2001 • 21 citations

Adenovirus-mediated transfer of regulable gene expression.

2000 • 19 citations

Ecdysteroids: Insect hormones, plant defensive factors, or human medicine?

1993 • 18 citations

Regulated Gene Expression in Gene Therapy

2001 • 18 citations

EcR interacts with corepressors and harbours an autonomous silencing domain functional in both Drosophila and vertebrate cells.

1999 • 13 citations

Effect of ecdysterone treatment on the cyclic AMP-protein kinase system in adipose tissue

1982 • 12 citations

Steroid Hormone-Inducible Expression of the GLT-1 Subtype of High-Affinity l-Glutamate Transporter in Human Embryonic Kidney Cells

1999 • 12 citations

Ecdysteroid-like compounds in the serum and urine of African patients infected with Loa loa and Mansonella perstans microfilariae

1990 • 9 citations

Ecdysteroid-like compounds in human urine: they can occur in the absence of any parasitic infection

1991 • 6 citations

Source and Availability of Ecdysterones

1974 • 5 citations

Cell surface receptor interactions of C27-steroid hormone ecdysterone immobilized on nanodispersed magnetite

1999 • 4 citations

Ecdysteroids in urine of African patients infected with helminths

1990 • 4 citations

[Immunomodulating effect of ecdysterones].

1992 • 4 citations