Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: Elevated mrna transcripts, protein synthesis, and accumulation in bone of mutant animals

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Biostatistical Analysis.

1975 • 10,200 citations

Cleavage of structural proteins during the assemble of the head of bacterio-phage T4

1970 • 5,738 citations

Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography

1975 • 4,693 citations

Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

1990 • 1,546 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

1988 • 943 citations

Osteopontin--a possible anchor of osteoclasts to bone.

1990 • 816 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Construction of DNA sequences complementary to rat .alpha.1 and .alpha.2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D

1984 • 568 citations

The Nature and Significance of Osteopontin

1989 • 561 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

Osteoblastic Cells Mediate Osteoclastic Responsiveness to Parathyroid Hormone*

1986 • 411 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

Isolation, characterization, and biosynthesis of a phosphorylated glycoprotein from rat bone.

1987 • 373 citations

Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression.

1989 • 372 citations

Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures*

1991 • 352 citations

Osteocalcin: Isolation, characterization, and detection

1984 • 337 citations

Recruitment of osteoclast precursors by purified bone matrix constituents.

1982 • 266 citations

A Specific High-Affinity Binding Macromolecule for 1,25-Dihydroxyvitamin D ₃ in Fetal Bone

1977 • 246 citations

Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.

1988 • 206 citations

Differential staining of phosphoproteins on polyacrylamide gels with a cationic carbocyanine dye

1973 • 203 citations

1,25-Dihydroxyvitamin D3 Regulates the Biosynthesis of Osteopontin, a Bone-Derived Cell Attachment Protein, in Clonal Osteoblast-Like Osteosarcoma Cells

1987 • 187 citations

Immunohistochemical demonstration of a 44-KD phosphoprotein in developing rat bones.

1987 • 187 citations

Deficiency of Osteoclasts in Osteopetrotic Mice Is Due to a Defect in the Local Microenvironment Provided by Osteoblastic Cells*

1991 • 159 citations

In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections.

1992 • 156 citations

Impaired recruitment and differentiation of osteoclast progenitors by osteocalcin-deplete bone implants

1987 • 153 citations

Resorption of implanted bone prepared from normal and warfarin-treated rats.

1984 • 153 citations

A role for osteocalcin in osteoclast differentiation

1991 • 148 citations

Molecular cloning of a tumor promoter‐inducible mRNA found in JB6 mouse epidermal cells: Induction is stable at high, but not at low, cell densities

1987 • 132 citations

Characterization of fetal porcine bone sialoproteins, secreted phosphoprotein I (SPPI, osteopontin), bone sialoprotein, and a 23-kDa glycoprotein. Demonstration that the 23-kDa glycoprotein is derived from the carboxyl terminus of SPPI.

1990 • 128 citations

Skeletal Tissue Response to Cytokines

1990 • 116 citations

Osteoclast biology: Lessons from mammalian mutations

1989 • 111 citations

cDNA cloning of alkaline phosphatase from rat osteosarcoma (ROS 17/2.8) cells

1987 • 107 citations

Regulation of bone sialoprotein mRNA by steroid hormones.

1989 • 105 citations

Reduction of retinaldehyde bound to cellular retinol-binding protein (type II) by microsomes from rat small intestine.

1988 • 104 citations

Multiple forms of SppI (secreted phosphoprotein, osteopontin) synthesized by normal and transformed rat bone cell populations: Regulation by TGF-β

1989 • 103 citations

Induction of expression of osteopontin (OPN; secreted phosphoprotein) in metastatic, ras-transformed NIH 3T3 cells.

1992 • 97 citations

Expression and ultrastructural immunolocalization of a major 66 kDa phosphoprotein synthesized by chicken osteoblasts during mineralization in vitro

1990 • 82 citations

A rat histone H4 gene closely associated with the testis-specific H1t gene

1987 • 80 citations

The identification of O‐phosphothreonine in the soluble non‐collagenous phosphoproteins of bone matrix

1978 • 63 citations

Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities

1991 • 63 citations

Osteopetrosis in the Rat: Coexistence of Reductions in Osteocalcin and Bone Resorption*

1990 • 61 citations

Normal bone particles are preferentially resorbed in the presence of osteocalcin-deficient bone particlesIn vivo

1991 • 55 citations

Biosynthesis and secretion of an osteopontin-related 20-kDa polypeptide in the Madin-Darby canine kidney cell line

1991 • 45 citations

Elevated serum 1,25-dihydroxyvitamin D in osteopetrotic mutations in three species.

1987 • 41 citations

Functional and Molecular Changes in Colony Stimulating Factor Secretion by Osteoblasts

1989 • 35 citations

Parathyroid hormone stimulation of alkaline phosphatase activity in cultured neonatal mouse calvarial bone cells: Involvement of cyclic AMP and calcium

1986 • 32 citations