Neurite outgrowth in PC12 cells deficient in GAP-43

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

Axonal Growth-Associated Proteins

1989 • 1,118 citations

pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin

1988 • 1,039 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Do the poly(A) tail and 3′ untranslated region control mRNA translation?

1990 • 618 citations

Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems

1981 • 583 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

1986 • 526 citations

A Protein Induced During Nerve Growth (GAP-43) is a Major Component of Growth-Cone Membranes

1986 • 505 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells.

1981 • 495 citations

G0 is a major growth cone protein subject to regulation by GAP-43

1990 • 422 citations

Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones

1988 • 413 citations

Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain

1988 • 390 citations

Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43.

1989 • 383 citations

Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth

1987 • 358 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein

1987 • 351 citations

The growth-associated protein gap-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury

1990 • 324 citations

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.

1986 • 282 citations

Inhibition of noradrenaline release by antibodies to B-50 (GAP-43)

1989 • 267 citations

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

1988 • 262 citations

Newly Identified Brain Potassium Channels Gated by the Guanine Nucleotide Binding Protein G _o

1988 • 236 citations

Purification of a novel calmodulin-binding protein from bovine cerebral cortex membranes

1983 • 225 citations

Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons

1989 • 217 citations

Cholinergic metabolism and synapse formation by a rat nerve cell line.

1977 • 217 citations

The Neuronal Growth-Associated Protein GAP-43 Induces Filopodia in Non-Neuronal Cells

1989 • 216 citations

Changes in the distribution of GAP-43 during the development of neuronal polarity

1990 • 216 citations

Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain.

1988 • 212 citations

MAP5: A novel brain microtubule-associated protein under strong developmental regulation

1986 • 210 citations

Characterization of protein F1 (47 kDa, 4.5 pI): A kinase C substrate directly related to neural plasticity

1985 • 204 citations

A selective increase in phosphorylation of protein F1, a protein kinase C substrate, directly related to three day growth of long term synaptic enhancement

1985 • 200 citations

Detection of Gene Expression

1989 • 192 citations

Nerve growth cones isolated from fetal rat brain. III. Calcium- dependent protein phosphorylation

1985 • 185 citations

Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts

1986 • 182 citations

Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids.

1988 • 181 citations

Differential G protein—mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro

1989 • 180 citations

GAP-43 in growth cones is associated with areas of membrane that are tightly bound to substrate and is a component of a membrane skeleton subcellular fraction

1990 • 178 citations

GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system

1989 • 178 citations

A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43

1989 • 176 citations

Primary structure and mRNA localization of protein F1, a growth-related protein kinase C substrate associated with synaptic plasticity.

1987 • 172 citations

Distribution and phosphorylation of the growth-associated protein GAP- 43 in regenerating sympathetic neurons in culture

1988 • 162 citations

Selective increase in phosphorylation of a 47-kDa protein (F1) directly related to long-term potentiation

1985 • 152 citations

P-57 is a neural specific calmodulin-binding protein.

1985 • 152 citations

The neuronal growth-associated protein GAP-43 (B-50, F1): neuronal specificity, developmental regulation and regional distribution of the human and rat mRNAs

1987 • 151 citations

Localization of the growth-associated phosphoprotein GAP-43 (B-50, F1) in the human cerebral cortex

1989 • 151 citations

Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration

1990 • 143 citations

Synergistic effects of cyclic AMP and nerve growth factor on neurite outgrowth and microtubule stability of PC12 cells.

1985 • 140 citations

Cloning of human GAP 43: Growth association and ischemic resurgence

1988 • 138 citations

PC12 cells express juvenile microtubule-associated proteins during nerve growth factor-induced neurite outgrowth.

1988 • 133 citations

Cell culture in the neurosciences

1986 • 127 citations

Characterization of murine cDNAs encoding P-57, a neural-specific calmodulin-binding protein.

1987 • 124 citations

Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells.

1989 • 117 citations

PC12 Cells as a Model of Neuronal Differentiation

1985 • 110 citations

Selective conservation of GAP-43 structure in vertebrate evolution

1989 • 97 citations

Ultrastructural immunocytochemical localization of B-50/GAP43, a protein kinase C substrate, in isolated presynaptic nerve terminals and neuronal growth cones

1989 • 93 citations

The neuronal growth-associated protein GAP-43 (B-50, F1): neuronal specificity, developmental regulation and regional distribution of the human and rat mRNAs

1987 • 92 citations

The neurite-promoting effect of fibroblast growth factor on PC12 cells

1983 • 88 citations

Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor

1980 • 85 citations

Factors influencing GAP-43 gene expression in PC12 pheochromocytoma cells

1990 • 85 citations

Chicken Growth‐Associated Protein GAP‐43 Is Tightly Bound to the Actin‐Rich Neuronal Membrane Skeleton

1990 • 79 citations

Evidence for the coidentification of GAP-43, a growth-associated protein, and F1, a plasticity-associated protein

1987 • 75 citations

Light- and electron-microscopical study of phosphoprotein B-50 following denervation and reinnervation of the rat soleus muscle

1988 • 73 citations

Calcium-promoted translocation of protein kinase C to synaptic membranes: relation to the phosphorylation of an endogenous substrate (protein F1) involved in synaptic plasticity

1987 • 66 citations

Depolarization‐Induced Phosphorylation of the Protein Kinase C Substrate B‐50 (GAP‐43) in Rat Cortical Synaptosomes

1990 • 65 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones

1986 • 52 citations

Nerve growth factor enhances the level of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells

1986 • 48 citations

4‐Aminopyridine Stimulates B‐50 (GAP43) Phosphorylation and [³H]Noradrenaline Release in Rat Hippocampal Slices

1990 • 41 citations

Chapter 20 Long-term potentiation and 4-aminopyridine-induced changes in protein and lipid phosphorylation in the hippocampal slice

1986 • 26 citations

In vitro reinnervation of adult rat muscle fibres by foreign neurons and transformed chromaffin PC12 cells

1988 • 8 citations