p53 tumor suppressor protein regulates the levels of huntingtin gene expression

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

2000 • 1,033 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1995 • 843 citations

Huntingtin–protein interactions and the pathogenesis of Huntington's disease

2004 • 526 citations

Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro

2004 • 499 citations

The p53 functional circuit

2001 • 302 citations

The p53MH algorithm and its application in detecting p53-responsive genes

2002 • 292 citations

Neurobiology of Huntington's Disease

1996 • 135 citations

Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease

1999 • 90 citations

MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation

2002 • 85 citations

Activation of an MDM2-specific Caspase by p53 in the Absence of Apoptosis

1999 • 66 citations

Different phenotypic expression in monozygotic twins with Huntington disease

2003 • 44 citations

Mouse Huntington’s Disease Homolog mRNA Levels: Variation and Allele Effects

2003 • 25 citations