Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry

Bipolar Disorder

2011 • 3,572 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

The Long-term Natural History of the Weekly Symptomatic Status of Bipolar I Disorder

2002 • 2,037 citations

Conceptualization and Rationale for Consensus Definitions of Terms in Major Depressive Disorder

1991 • 1,896 citations

"A Controlled Study"

1966 • 1,737 citations

Manic-Depressive Insanity and Paranoia.

1921 • 1,607 citations

LITHIUM SALTS IN THE TREATMENT OF PSYCHOTIC EXCITEMENT

1949 • 1,401 citations

A Prospective Investigation of the Natural History of the Long-term Weekly Symptomatic Status of Bipolar II Disorder

2003 • 1,195 citations

Manic Depressive Insanity and Paranoia

1921 • 1,183 citations

Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology

2016 • 1,181 citations

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

2012 • 1,164 citations

Lithium salts in the treatment of psychotic excitement

1999 • 1,158 citations

Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data

2004 • 1,074 citations

A Double-Blind Placebo-Controlled Study of Lamotrigine Monotherapy in Outpatients With Bipolar I Depression

1999 • 1,056 citations

Clinical Response and Risk for Reported Suicidal Ideation and Suicide Attempts in Pediatric Antidepressant Treatment

2007 • 1,043 citations

Translating Research Into Practice: The Schizophrenia Patient Outcomes Research Team (PORT) Treatment Recommendations

1998 • 937 citations

Effectiveness of Adjunctive Antidepressant Treatment for Bipolar Depression

2007 • 917 citations

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

2010 • 911 citations

Efficacy of Olanzapine and Olanzapine-Fluoxetine Combination in the Treatment of Bipolar I Depression

2003 • 891 citations

Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania

1994 • 872 citations

A Randomized, Double-Blind, Placebo-Controlled Trial of Quetiapine in the Treatment of Bipolar I or II Depression

2005 • 860 citations

Omega 3 Fatty Acids in Bipolar Disorder

1999 • 815 citations

A Randomized Trial on the Efficacy of Group Psychoeducation in the Prophylaxis of Recurrences in Bipolar Patients Whose Disease Is in Remission

2003 • 786 citations

The emerging epidemiology of hypomania and bipolar II disorder

1998 • 767 citations

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

2012 • 758 citations

The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases

2002 • 751 citations

A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder

2000 • 683 citations

THE EVOLVING BIPOLAR SPECTRUM

1999 • 680 citations

A Placebo-Controlled 18-Month Trial of Lamotrigine and Lithium Maintenance Treatment in Recently Manic or Hypomanic Patients With Bipolar I Disorder

2003 • 661 citations

A Placebo-Controlled 18-Month Trial of Lamotrigine and Lithium Maintenance Treatment in Recently Depressed Patients With Bipolar I Disorder

2003 • 629 citations

Long-Term Lithium Therapy for Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials

2004 • 624 citations

Lithium in the Prevention of Suicidal Behavior and All-Cause Mortality in Patients With Mood Disorders: A Systematic Review of Randomized Trials

2005 • 601 citations

Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis

2011 • 599 citations

Practice guideline for the treatment of patients with bipolar disorder. American Psychiatric Association

1994 • 592 citations

Early Evidence on the Effects of Regulators’ Suicidality Warnings on SSRI Prescriptions and Suicide in Children and Adolescents

2007 • 582 citations

A Pooled Analysis of 2 Placebo-Controlled 18-Month Trials of Lamotrigine and Lithium Maintenance in Bipolar I Disorder

2004 • 582 citations

Olanzapine Versus Placebo in the Treatment of Acute Mania

1999 • 580 citations

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009

2009 • 570 citations

Drug Therapy in the Prevention of Recurrences in Unipolar and Bipolar Affective Disorders

1984 • 569 citations

Lithium As a Prophylactic Agent

1967 • 569 citations

Efficacy of Olanzapine in Acute Bipolar Mania<subtitle>A Double-blind, Placebo-Controlled Study</subtitle>

2000 • 557 citations

Efficacy of Quetiapine Monotherapy in Bipolar I and II Depression

2006 • 555 citations

Antidepressants for Bipolar Depression: A Systematic Review of Randomized, Controlled Trials

2004 • 553 citations

Functional outcome in bipolar disorder: the role of clinical and cognitive factors

2007 • 548 citations

The Prevalent Clinical Spectrum of Bipolar Disorders: Beyond DSM-IV

1996 • 546 citations

Outcome in Mania

1990 • 541 citations

THE TREATMENT OF MANIC PSYCHOSES BY THE ADMINISTRATION OF LITHIUM SALTS

1954 • 539 citations

Double-Blind and Placebo-Controlled Study of Lithium for Adolescent Bipolar Disorders With Secondary Substance Dependency

1998 • 519 citations

Psychosocial Treatments for Bipolar Depression

2007 • 509 citations

Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial

2010 • 503 citations

PROPHYLACTIC LITHIUM: DOUBLE BLIND DISCONTINUATION IN MANIC-DEPRESSIVE AND RECURRENT-DEPRESSIVE DISORDERS

1970 • 500 citations

A Placebo-Controlled, Double-Blind Study of the Efficacy and Safety of Aripiprazole in Patients With Acute Bipolar Mania

2003 • 497 citations

A Double-Blind, Placebo-Controlled, Prophylaxis Study of Lamotrigine in Rapid-Cycling Bipolar Disorder

2000 • 492 citations

Schizophrenia, just the facts

1988 • 486 citations

Carbamazepine in manic-depressive illness: a new treatment

1980 • 485 citations

N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

2008 • 479 citations

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders in Primary Care

2007 • 473 citations

12-Month Outcome of Patients With Bipolar Disorder Following Hospitalization for a Manic or Mixed Episode

1998 • 459 citations

A Placebo-Controlled Study of Lamotrigine and Gabapentin Monotherapy in Refractory Mood Disorders

2000 • 455 citations

National Trends in Psychotropic Medication Polypharmacy in Office-Based Psychiatry

2010 • 453 citations

Lithium Carbonate and Imipramine in Prevention of Affective Episodes

1973 • 450 citations

Efficacy of Olanzapine in Combination With Valproate or Lithium in the Treatment of Mania in Patients Partially Nonresponsive to Valproate or Lithium Monotherapy

2002 • 450 citations

Valproatereatment of Acute Mania

1991 • 441 citations

Combination of a Mood Stabilizer With Risperidone or Haloperidol for Treatment of Acute Mania: A Double-Blind, Placebo-Controlled Comparison of Efficacy and Safety

2002 • 419 citations

Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials

2008 • 419 citations

Evidence-based guidelines for treating bipolar disorder: revised second edition—recommendations from the British Association for Psychopharmacology

2009 • 418 citations

Risk of Switch in Mood Polarity to Hypomania or Mania in Patients With Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers

2006 • 403 citations

The Expert Consensus Guideline Series

2001 • 402 citations

The Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder 2000.

2000 • 399 citations

Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies

2005 • 396 citations

Double-Blind, Placebo-Controlled Comparison of Imipramine and Paroxetine in the Treatment of Bipolar Depression

2001 • 392 citations

Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode

2011 • 391 citations

Evidence-Based Guidelines for Treating Bipolar Disorder: Recommendations from the British Association for Psychopharmacology

2003 • 387 citations

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression

2010 • 385 citations

A Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Quetiapine or Lithium as Monotherapy for Mania in Bipolar Disorder

2005 • 381 citations

Is Response to Prophylactic Lithium a Familial Trait?

2002 • 374 citations

Ziprasidone in the Treatment of Acute Bipolar Mania: A Three-Week, Placebo-Controlled, Double-Blind, Randomized Trial

2003 • 368 citations

Schizophrenia, “Just the Facts” 5. Treatment and prevention Past, present, and future

2010 • 367 citations

A Double-Blind, Placebo-Controlled Study of Quetiapine and Lithium Monotherapy in Adults in the Acute Phase of Bipolar Depression (EMBOLDEN I)

2010 • 366 citations

Course and outcome in bipolar affective disorder: a longitudinal follow- up study

1995 • 366 citations

Tranylcypromine versus imipramine in anergic bipolar depression

1991 • 364 citations

Olanzapine Versus Lithium in the Maintenance Treatment of Bipolar Disorder: A 12-Month, Randomized, Double-Blind, Controlled Clinical Trial

2005 • 363 citations

World Trade Report 2003

2003 • 356 citations

Olanzapine Versus Divalproex Sodium for the Treatment of Acute Mania and Maintenance of Remission: A 47-Week Study

2003 • 355 citations

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Extended-Release Carbamazepine Capsules as Monotherapy for Bipolar Disorder Patients With Manic or Mixed Episodes

2004 • 354 citations

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2009 on the Treatment of Acute Mania

2009 • 346 citations

Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone

2004 • 335 citations

Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline

2006 • 335 citations

Pramipexole for bipolar II depression: a placebo-controlled proof of concept study

2004 • 327 citations

Association between antidepressant prescribing and suicide in Australia, 1991-2000: trend analysis

2003 • 326 citations

Stones in the kidney and ureter.

1948 • 323 citations

Gabapentin in bipolar disorder: a placebo‐controlled trial of adjunctive therapy1

2000 • 318 citations

Comparative Prophylactic Efficacy of Lithium, Carbamazepine, and the Combination in Bipolar Disorder

1997 • 313 citations

Randomized, Placebo-Controlled Trial of Olanzapine as Maintenance Therapy in Patients With Bipolar I Disorder Responding to Acute Treatment With Olanzapine

2006 • 313 citations

A double-blind comparison of valproate and lithium in the treatment of acute mania

1992 • 312 citations

Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: Randomised double-blind placebo-controlled study

2005 • 308 citations

Diagnostic conversion from depression to bipolar disorders: results of a long-term prospective study of hospital admissions

2003 • 303 citations

Antidepressant‐induced mania: an overview of current controversies

2003 • 301 citations

A Double-Blind, Placebo-Controlled Study of Quetiapine and Paroxetine as Monotherapy in Adults With Bipolar Depression (EMBOLDEN II)

2010 • 300 citations

Gender, temperament, and the clinical picture in dysphoric mixed mania: findings from a French national study (EPIMAN)

1998 • 294 citations

Twelve-Month Outcome After a First Hospitalization for Affective Psychosis

1998 • 290 citations

A Randomized, Double-Blind, Placebo-Controlled 26-Week Trial of Aripiprazole in Recently Manic Patients With Bipolar I Disorder

2006 • 289 citations

Manic-Depressive Illness

2007 • 288 citations

Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double‐blind, randomized, placebo‐controlled study

2008 • 286 citations

Clinical and therapeutic implications of predominant polarity in bipolar disorder

2006 • 284 citations

Impact of Antidepressant Discontinuation After Acute Bipolar Depression Remission on Rates of Depressive Relapse at 1-Year Follow-Up

2003 • 283 citations

Prophylactic Efficacy of Lithium Carbonate in Manic-Depressive Illness

1973 • 283 citations

A double-blind trial of bupropion versus desipramine for bipolar depression.

1994 • 281 citations

Psychoeducation Efficacy in Bipolar Disorders

2003 • 275 citations

Clinical Pharmacokinetics and Pharmacological Effects of Carbamazepine and Carbamazepine-10,11-Epoxide

1986 • 273 citations

Importance of Psychiatric Diagnosis in Prediction of Clinical Drug Effects

1967 • 273 citations

Evidence-based medicine and the practicing clinician

1999 • 269 citations

World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia

2008 • 268 citations

Clinical Practice Guidelines for Bipolar Disorder From the Department of Veterans Affairs

1999 • 268 citations

Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double‐blind, placebo‐controlled study

2004 • 267 citations

Antidepressants for the Acute Treatment of Bipolar Depression

2010 • 265 citations

Lower suicide risk with long‐term lithium treatment in major affective illness: a meta‐analysis

2001 • 264 citations

Patterns of Psychotropic Drug Prescription for U.S. Patients With Diagnoses of Bipolar Disorders

2007 • 264 citations

Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007

2006 • 262 citations

Texas Medication Algorithm Project

1998 • 261 citations

Lithium versus carbamazepine in the maintenance treatment of bipolar disorders – a randomised study

1997 • 260 citations

Rapid Antimanic Effect of Risperidone Monotherapy: A 3-Week Multicenter, Double-Blind, Placebo-Controlled Trial

2004 • 259 citations

Olanzapine Versus Divalproex in the Treatment of Acute Mania

2002 • 258 citations

Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder

2001 • 258 citations

Mood stabilisers plus risperidone or placebo in the treatment of acute mania

2003 • 258 citations

A Comparison of Fluoxetine Imipramine and Placebo in Patients with Bipolar Depressive Disorder

1989 • 256 citations

Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder

2009 • 256 citations

A Double-Blind, Randomized Comparison of the Efficacy and Safety of Intramuscular Injections of Olanzapine, Lorazepam, or Placebo in Treating Acutely Agitated Patients Diagnosed With Bipolar Mania

2001 • 255 citations

Haloperidol alone or in combination for acute mania

2006 • 255 citations

Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study

2006 • 251 citations

Efficacy of Antimanic Treatments: Meta-analysis of Randomized, Controlled Trials

2010 • 248 citations

Comparison of Lithium Carbonate and Chlorpromazine in the Treatment of Mania

1972 • 245 citations

A 20-Month, Double-Blind, Maintenance Trial of Lithium Versus Divalproex in Rapid-Cycling Bipolar Disorder

2005 • 244 citations

Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial.

1998 • 244 citations

Aripiprazole Monotherapy in Nonpsychotic Bipolar I Depression

2008 • 243 citations

Second-Generation Antipsychotic Agents in the Treatment of Acute Mania

2007 • 243 citations

A Placebo-Controlled Evaluation of Adjunctive Modafinil in the Treatment of Bipolar Depression

2007 • 241 citations

Aripiprazole Monotherapy for Maintenance Therapy in Bipolar I Disorder

2007 • 241 citations

Residual Symptom Recovery From Major Affective Episodes in Bipolar Disorders and Rapid Episode Relapse/Recurrence

2008 • 241 citations

Omega-3 for Bipolar Disorder

2011 • 237 citations

Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy

2003 • 236 citations

Lamotrigine in the acute treatment of bipolar depression: results of five double‐blind, placebo‐controlled clinical trials

2008 • 236 citations

Mania associated with antidepressant treatment: comprehensive meta‐analytic review

2009 • 233 citations

Quetiapine or haloperidol as monotherapy for bipolar mania—a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial

2005 • 233 citations

Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder

2013 • 232 citations

Electroconvulsive Treatment Compared With Lithium in the Management of Manic States

1988 • 232 citations

A 12-Week, Double-blind Comparison of Olanzapine vs Haloperidol in the Treatment of Acute Mania

2003 • 231 citations

Incidence and Significance of Mixed Affective States in a Bipolar Population

1976 • 231 citations

Effect of sodium valproate on mania

1980 • 231 citations

Efficacy and Safety of Lamotrigine as Add-On Treatment to Lithium in Bipolar Depression

2008 • 230 citations

Double-Blind, Randomized, Placebo-Controlled Trials of Ethyl-Eicosapentanoate in the Treatment of Bipolar Depression and Rapid Cycling Bipolar Disorder

2006 • 228 citations

Maintenance Treatment for Patients With Bipolar I Disorder: Results From a North American Study of Quetiapine in Combination With Lithium or Divalproex (Trial 127)

2009 • 228 citations

A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders

2006 • 228 citations

Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126)

2008 • 227 citations

Lithium for maintenance treatment of mood disorders

2001 • 226 citations

Comparison of the antimanic efficacy of carbamazepine and chlorpromazine: A double-blind controlled study

1979 • 225 citations

A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness

1981 • 225 citations

A Randomized Trial Comparing Paroxetine and Venlafaxine in the Treatment of Bipolar Depressed Patients Taking Mood Stabilizers

2002 • 224 citations

Review of the Use of Topiramate for Treatment of Bipolar Disorders

2002 • 217 citations

Lithium Carbonate and Imipramine in the Prophylaxis of Unipolar and Bipolar II Illness

1982 • 213 citations

Differential Response to Lithium and Carbamazepine in the Prophylaxis of Bipolar Disorder

1998 • 212 citations

Adjunctive Antidepressant Use and Symptomatic Recovery Among Bipolar Depressed Patients With Concomitant Manic Symptoms: Findings From the STEP-BD

2007 • 212 citations

Protein Kinase C Inhibition in the Treatment of Mania

2008 • 210 citations

A 7-Week, Randomized, Double-Blind Trial of Olanzapine/Fluoxetine Combination Versus Lamotrigine in the Treatment of Bipolar I Depression

2006 • 209 citations

Double-Blind Comparison of Addition of a Second Mood Stabilizer Versus an Antidepressant to an Initial Mood Stabilizer for Treatment of Patients With Bipolar Depression

2000 • 209 citations

Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: a comparative analysis of acute, randomized, placebo‐controlled trials

2010 • 205 citations

Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study

2007 • 203 citations

Double-Blind 18-Month Trial of Lithium Versus Divalproex Maintenance Treatment in Pediatric Bipolar Disorder

2005 • 203 citations

Specificity of Cognitive Deficits in Bipolar Disorder versus Schizophrenia

2006 • 202 citations

Lithium treatment and suicide risk in major affective disorders: update and new findings.

2003 • 201 citations

Atypical Antipsychotics in the Treatment of Mania

2006 • 199 citations

A Randomized Controlled Trial of Cognitive Therapy for Bipolar Disorder

2006 • 197 citations

The Expert Consensus Guideline Series. Treatment of behavioral emergencies.

2001 • 195 citations

Clinical Outcome in a Randomized 1-Year Trial of Clozapine Versus Treatment as Usual for Patients With Treatment-Resistant Illness and a History of Mania

2003 • 193 citations

A 3‐week, randomized, placebo‐controlled trial of asenapine in the treatment of acute mania in bipolar mania and mixed states

2009 • 192 citations

Oxcarbazepine for acute affective episodes in bipolar disorder

2011 • 192 citations

Carbamazepine Compared With Lithium in the Treatment of Mania

1991 • 191 citations

Risperidone in the treatment of acute mania

2005 • 189 citations

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Bipolar Disorders, Part I: Treatment of Bipolar Depression

2002 • 189 citations

Topiramate monotherapy in the management of acute mania: results of four double‐blind placebo‐controlled trials

2006 • 182 citations

Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol

2004 • 178 citations

The International Society for Bipolar Disorders (ISBD) consensus guidelines for the safety monitoring of bipolar disorder treatments

2009 • 177 citations

Suicide Risk in Patients Treated With Lithium

2005 • 177 citations

Effectiveness of aripiprazole v. Haloperidol in acute bipolar mania

2005 • 176 citations

Risperidone Long-Acting Injectable Monotherapy in the Maintenance Treatment of Bipolar I Disorder

2010 • 176 citations

Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder

2011 • 175 citations

ECT in bipolar and unipolar depression: differences in speed of response

2001 • 175 citations

Users' Guides to the Medical Literature

1999 • 175 citations

Valproate as an Adjunct to Neuroleptic Medication for the Treatment of Acute Episodes of Mania: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study

2000 • 175 citations

A Comparison of the Efficacy, Safety, and Tolerability of Divalproex Sodium and Olanzapine in the Treatment of Bipolar Disorder

2002 • 175 citations

Treatment and Prevention

1992 • 175 citations

The World Federation of Socleties of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part II: Treatment of Mania

2003 • 174 citations

Efficacy and Safety of Fluoxetine in Treating Bipolar II Major Depressive Episode

1998 • 173 citations

Divalproex in the treatment of bipolar depression: a placebo-controlled study

2004 • 172 citations

Treatment guidelines for bipolar disorder: A critical review

2005 • 172 citations

Forty Years of Lithium Treatment

1997 • 171 citations

Quetiapine Versus Placebo in Combination With Lithium or Divalproex for the Treatment of Bipolar Mania

2004 • 171 citations

Lamotrigine

2003 • 170 citations

Olanzapine compared to lithium in mania: a double-blind randomized controlled trial

1999 • 170 citations

The Prospective Course of Rapid-Cycling Bipolar Disorder: Findings From the STEP-BD

2008 • 170 citations

Aripiprazole monotherapy in the treatment of acute bipolar I mania: A randomized, double-blind, placebo- and lithium-controlled study

2008 • 169 citations

Impact of a Psychoeducational Family Intervention on Caregivers of Stabilized Bipolar Patients

2004 • 169 citations

PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers

2002 • 167 citations

Treatment of bipolar disorder: a systematic review of available data and clinical perspectives

2008 • 166 citations

Persistent Neuropsychological Deficit in Euthymic Bipolar Patients

2007 • 164 citations

Extended-Release Carbamazepine Capsules as Monotherapy for Acute Mania in Bipolar Disorder

2005 • 164 citations

Maintenance Efficacy of Divalproex in the Prevention of Bipolar Depression

2003 • 163 citations

Long‐term antidepressant treatment in bipolar disorder: meta‐analyses of benefits and risks

2008 • 162 citations

Continuation of Quetiapine Versus Switching to Placebo or Lithium for Maintenance Treatment of Bipolar I Disorder

2011 • 162 citations

Asenapine in the treatment of acute mania in bipolar I disorder: A randomized, double-blind, placebo-controlled trial

2010 • 162 citations

Lithium-discontinuation-induced refractoriness: preliminary observations

1992 • 161 citations

Rapid and Non-Rapid Cycling Bipolar Disorder

2003 • 160 citations

Efficacy of Adjunctive Aripiprazole to Either Valproate or Lithium in Bipolar Mania Patients Partially Nonresponsive to Valproate/Lithium Monotherapy: A Placebo-Controlled Study

2008 • 160 citations

Ziprasidone in Acute Bipolar Mania

2005 • 159 citations

Lithium response and genetics of affective disorders

1994 • 159 citations

Treatment of Suicide Attempters With Bipolar Disorder: A Randomized Clinical Trial Comparing Lithium and Valproate in the Prevention of Suicidal Behavior

2011 • 157 citations

A randomized, double‐blind, placebo‐controlled study of maintenance treatment with adjunctive risperidone long‐acting therapy in patients with bipolar I disorder who relapse frequently

2009 • 157 citations

Practice Parameters for the Assessment and Treatment of Children and Adolescents With Bipolar Disorder

1997 • 156 citations

Prophylactic Lithium: A Double-Blind Trial in Recurrent Affective Disorders

1970 • 156 citations

Antidepressants and suicide: what is the balance of benefit and harm

2004 • 155 citations

Do antidepressants t(h)reat(en) depressives? Toward a clinically judicious formulation of the antidepressant–suicidality FDA advisory in light of declining national suicide statistics from many countries

2006 • 155 citations

The use of lithium in manic-depressive psychosis

1964 • 154 citations

Carbamazepine vs Lithium in the Treatment and Prophylaxis of Mania

1988 • 153 citations

Carbamazepine and Haloperidol v Placebo and Haloperidol in Excited Psychoses

1984 • 153 citations

Psychoactive Drugs in Mania

1975 • 153 citations

Effect of symptoms on executive function in bipolar illness

2004 • 152 citations

Lower Switch Rate in Depressed Patients With Bipolar II Than Bipolar I Disorder Treated Adjunctively With Second-Generation Antidepressants

2006 • 147 citations

Effectiveness of the extended release formulation of quetiapine as monotherapy for the treatment of acute bipolar depression

2011 • 146 citations

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part III: Maintenance Treatment

2004 • 146 citations

Alcoholism and drug abuse in three groups — bipolar I, unipolars and their acquaintances

1998 • 145 citations

Prophylactic Efficacy of Lithium Versus Carbamazepine in Treatment-Naive Bipolar Patients

2003 • 145 citations

Double-Blind Comparison of the Continued Use of Antipsychotic Treatment Versus Its Discontinuation in Remitted Manic Patients

2004 • 144 citations

A controlled evaluation of lithium prophylaxis in affective disorders

1972 • 143 citations

Evidence for a biochemical lesion in depression.

2000 • 143 citations

Ziprasidone Plus a Mood Stabilizer in Subjects With Bipolar I Disorder

2010 • 142 citations

Efficacy and Safety of Long-Term Fluoxetine Versus Lithium Monotherapy of Bipolar II Disorder: A Randomized, Double-Blind, Placebo-Substitution Study

2010 • 142 citations

Enhancing medication adherence in patients with bipolar disorder

2009 • 142 citations

A Randomized, Placebo-Controlled, Multicenter Study of Divalproex Sodium Extended Release in the Treatment of Acute Mania

2006 • 142 citations

Family‐focused treatment for caregivers of patients with bipolar disorder

2010 • 141 citations

Antidepressant Discontinuation in Bipolar Depression

2010 • 141 citations

A re‐evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network

2003 • 141 citations

The comparative efficacy and safety of carbamazepine versus lithium: a randomized, double-blind 3-year trial in 83 patients.

1986 • 140 citations

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the Treatment of Acute Bipolar Depression

2011 • 139 citations

Depressive Illness Burden Associated With Complex Polypharmacy in Patients With Bipolar Disorder

2009 • 139 citations

Discoveries in Biological Psychiatry

1971 • 139 citations

Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial

1984 • 139 citations

A randomized comparison of divalproex oral loading versus haloperidol in the initial treatment of acute psychotic mania.

1996 • 138 citations

Carbamazepine versus lithium in the prophylaxis of bipolar affective disorder

1992 • 136 citations

Lithium prophylaxis of depression in bipolar I, bipolar II, and unipolar patients

1976 • 136 citations

Lithium Carbonate and Affective Disorders

1976 • 133 citations

PROPHYLACTIC LITHIUM IN RECURRENT AFFECTIVE DISORDERS

1972 • 133 citations

Self-Reported History of Manic/Hypomanic Switch Associated With Antidepressant Use

2007 • 132 citations

Medication Treatment for the Severely and Persistently Mentally Ill

1999 • 131 citations

Augmentative repetitive navigated transcranial magnetic stimulation (rTMS) in drug‐resistant bipolar depression

2009 • 130 citations

Review of the use of Topiramate for treatment of psychiatric disorders.

2005 • 130 citations

Efficacy of aripiprazole adjunctive to lithium or valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study

2011 • 129 citations

Antidepressant-Associated Mood Elevations in Bipolar II Disorder Compared With Bipolar I Disorder and Major Depressive Disorder

2008 • 128 citations

Safety and Tolerability of Oral Loading Divalproex Sodium in Acutely Manic Bipolar Patients

1999 • 128 citations

Carbamazepine versus lithium in mania: a double-blind study.

1987 • 128 citations

Carbamazepine and valproate monotherapy: feasibility, relative safety and efficacy, and therapeutic drug monitoring in manic disorder

2000 • 127 citations

The Impact of Antidepressant Discontinuation Versus Antidepressant Continuation on 1-Year Risk for Relapse of Bipolar Depression

2001 • 127 citations

Valproate for acute mood episodes in bipolar disorder

2003 • 125 citations

LITHIUM MAINTENANCE TREATMENT OF MANIC‐MELANCHOLIC PATIENTS: ITS ROLE IN THE DAILY ROUTINE

1976 • 125 citations

A Double-Blind, Randomized, Placebo-Controlled 4-Week Study on the Efficacy and Safety of the Purinergic Agents Allopurinol and Dipyridamole Adjunctive to Lithium in Acute Bipolar Mania

2008 • 125 citations

Quetiapine monotherapy for mania associated with bipolar disorder: combined analysis of two international, double-blind, randomised, placebo-controlled studies

2005 • 124 citations

Mood stabilizers in the prevention of recurrent affective disorders: a meta‐analysis

1999 • 123 citations

Differential Efficacy of Lithium and Carbamazepine in the Prophylaxis of Bipolar Disorder: Results of the MAP Study

2000 • 123 citations

Report of the Texas Consensus Conference Panel on Medication Treatment of Bipolar Disorder 2000

2002 • 122 citations

Valproate for the treatment of acute bipolar depression: Systematic review and meta-analysis

2009 • 120 citations

Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo‐controlled clinical trial with inhaled loxapine

2012 • 120 citations

Are antidepressants safe in the treatment of bipolar depression? A critical evaluation of their potential risk to induce switch into mania or cycle acceleration

2008 • 120 citations

Protein Kinase C Inhibition by Tamoxifen Antagonizes Manic-Like Behavior in Rats: Implications for the Development of Novel Therapeutics for Bipolar Disorder

2007 • 119 citations

Psychotropic drug prescription patterns among patients with bipolar I disorder

2000 • 119 citations

Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis

2009 • 118 citations

Divalproex sodium versus placebo in the treatment of acute bipolar depression: A systematic review and meta-analysis

2009 • 118 citations

Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD Participants

2006 • 118 citations

Psychoeducation in bipolar patients with comorbid personality disorders

2004 • 114 citations

Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk

1995 • 114 citations

Phenytoin as an Antimanic Anticonvulsant: A Controlled Study

2000 • 114 citations

Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers

2001 • 113 citations

Comparison of the Antimanic Efficacy of Carbamazepine and Lithium Carbonate by Double-Blind Controlled Study

1990 • 113 citations

Treatment Options for Bipolar Depression

2010 • 113 citations

Lithium Treatment of Acute Mania in Adolescents: A Placebo-Controlled Discontinuation Study

2004 • 112 citations

Lithium Plus Valproate Combination Therapy Versus Monotherapy for Relapse Prevention in Bipolar I Disorder (BALANCE): A Randomised Open-Label Trial

2011 • 112 citations

Adjunctive Armodafinil for Major Depressive Episodes Associated With Bipolar I Disorder

2010 • 111 citations

Texas Medication Algorithm Project, Phase 3 (TMAP-3)

2003 • 111 citations

A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder

2005 • 110 citations

Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid‐cycling disease course: a randomized, double‐blind, placebo‐controlled study

2007 • 110 citations

A comparison of haloperidol, lithium carbonate and their combination in the treatment of mania

1980 • 110 citations

SSRIs as mood stabilizers for Bipolar II Disorder? A proof of concept study

2006 • 109 citations

Lamotrigine compared with lithium in mania: a double-blind randomized controlled trial.

2000 • 108 citations

Divalproex in the Treatment of Acute Bipolar Depression

2007 • 108 citations

Asenapine versus olanzapine in acute mania: a double‐blind extension study

2009 • 108 citations

A randomized, placebo‐ and active‐controlled study of paliperidone extended release for the treatment of acute manic and mixed episodes of bipolar I disorder

2010 • 107 citations

Discoveries in Biological Psychiatry

1984 • 107 citations

Long-Term Mental Health Resource Utilization and Cost of Care Following Group Psychoeducation or Unstructured Group Support for Bipolar Disorders

2009 • 106 citations

Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study

2008 • 106 citations

Texas Medication Algorithm Project, Phase 3 (TMAP-3)

2003 • 105 citations

Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials

2011 • 104 citations

Stabilizing the stabilizer: group psychoeducation enhances the stability of serum lithium levels

2005 • 103 citations

N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial

2010 • 102 citations

Rate of switch in bipolar patients prospectively treated with second‐generation antidepressants as augmentation to mood stabilizers

2001 • 102 citations

Asenapine for long-term treatment of bipolar disorder: A double-blind 40-week extension study

2010 • 102 citations

Antiepileptics and Blood Dyscrasias: A Cohort Study

1998 • 102 citations

Randomized, double-blind pilot trial comparing lamotrigine versus citalopram for the treatment of bipolar depression

2006 • 102 citations

A Randomized, Double-Blind, Placebo-Controlled Add-On Trial of Quetiapine in Outpatients With Bipolar Disorder and Alcohol Use Disorders

2008 • 101 citations

The Effect of Carbamazepine and Lithium on Remission from Affective Illness

1987 • 101 citations

Mood state at study entry as predictor of the polarity of relapse in bipolar disorder

2004 • 101 citations

Transcranial magnetic stimulation in patients with bipolar depression: a double blind, controlled study

2002 • 100 citations

Efficacy and Safety of Adjunctive Oral Ziprasidone for Acute Treatment of Depression in Patients With Bipolar I Disorder

2011 • 99 citations

Mood-stabilisers reduce the risk of developing antidepressant-induced maniform states in acute treatment of bipolar I depressed patients

2001 • 99 citations

Texas Medication Algorithm Project: definitions, rationale, and methods to develop medication algorithms.

1998 • 99 citations

Adjunctive treatment of manic agitation with lorazepam versus haloperidol: a double-blind study.

1992 • 98 citations

Acute bipolar mania: a systematic review and meta‐analysis of co‐therapy vs. monotherapy

2006 • 98 citations

Risperidone and Paroxetine Given Singly and in Combination for Bipolar Depression

2004 • 98 citations

Cognitive behaviour therapy and supportive therapy for bipolar disorders: relapse rates for treatment period and 2-year follow-up

2011 • 98 citations

A 6-Month, Double-Blind, Maintenance Trial of Lithium Monotherapy Versus the Combination of Lithium and Divalproex for Rapid-Cycling Bipolar Disorder and Co-Occurring Substance Abuse or Dependence

2008 • 97 citations

Comparison of fluoxetine, olanzapine, and combined fluoxetine plus olanzapine initial therapy of bipolar type I and type II major depression—lack of manic induction

2005 • 95 citations

Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder

2002 • 95 citations

Olanzapine Versus Risperidone in the Treatment of Manic or Mixed States in Bipolar I Disorder

2006 • 95 citations

Venlafaxine monotherapy in women with bipolar II and unipolar major depression

2000 • 95 citations

The Bech-Rafaelsen Mania Scale in Clinical Trials of Therapies for Bipolar Disorder

2002 • 95 citations

Moclobemide vs. imipramine in bipolar depression: a multicentre double‐blindclinical trial

2001 • 94 citations

Divalproex, lithium and suicide among Medicaid patients with bipolar disorder

2007 • 93 citations

Valproate in the Treatment of Acute Mania

1996 • 92 citations

Comparison of Carbamazepine and Lithium in the Prophylaxis of Bipolar Disorders

1995 • 91 citations

Efficacy of high frequency (rapid) suprathreshold repetitive transcranial magnetic stimulation of right prefrontal cortex in bipolar mania: A randomized sham controlled study

2009 • 91 citations

Lithium versus antidepressants in the long-term treatment of unipolar affective disorder

2006 • 91 citations

Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder

2006 • 91 citations

Electroconvulsive therapy is equally effective in unipolar and bipolar depression

2009 • 91 citations

Second generation antipsychotics in the treatment of bipolar depression: a systematic review and meta-analysis

2011 • 90 citations

A Double-Blind, Randomized, Placebo-Controlled, Prophylaxis Study of Adjunctive Gabapentin for Bipolar Disorder

2006 • 90 citations

Atypical antipsychotics: newer options for mania and maintenance therapy

2005 • 90 citations

Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania

2010 • 89 citations

Asenapine as Adjunctive Treatment for Acute Mania Associated With Bipolar Disorder

2011 • 89 citations

A Comparison of Lithium Carbonate and Chlorpromazine in Mania

1970 • 89 citations

Typical and Atypical Antipsychotics in Bipolar Depression

2005 • 89 citations

A Randomized, Double‐Blind, Placebo‐Controlled Pilot Study of Naltrexone in Outpatients With Bipolar Disorder and Alcohol Dependence

2009 • 88 citations

Are Antidepressants Associated With New-Onset Suicidality in Bipolar Disorder?

2006 • 88 citations

Lamotrigine Compared with Lithium in Mania: A Double-Blind Randomized Controlled Trial

2000 • 88 citations

RAPID RECURRENCE OF MANIA FOLLOWING ABRUPT DISCONTINUATION OF LITHIUM

1988 • 88 citations

Diagnostic criteria for bipolarity based on an international sample of 5,635 patients with DSM-IV major depressive episodes

2011 • 87 citations

Physical treatments for bipolar disorder: A review of electroconvulsive therapy, stereotactic surgery and other brain stimulation techniques

2010 • 86 citations

Treatment of bipolar depression: An update

2007 • 85 citations

Rates of response, euthymia and remission in two placebo‐controlled olanzapine trials for bipolar mania

2003 • 85 citations

Meta-analysis: Methods, strengths, weaknesses, and political uses

2006 • 85 citations

A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder

2004 • 85 citations

Olanzapine Versus Divalproex Versus Placebo in the Treatment of Mild to Moderate Mania

2008 • 84 citations

A double-blind, randomized, placebo-controlled prophylaxis trial of oxcarbazepine as adjunctive treatment to lithium in the long-term treatment of bipolar I and II disorder

2008 • 84 citations

Psychopharmacological treatment with lithium and antiepileptic drugs: suggested guidelines from the Danish Psychiatric Association and the Child and Adolescent Psychiatric Association in Denmark

2003 • 84 citations

A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic?

2007 • 83 citations

Are bipolar II patients cognitively impaired? A systematic review

2011 • 83 citations

A meta-analysis of the use of typical antipsychotic agents in bipolar disorder

2001 • 82 citations

Combined Chlorpromazine and Electroconvulsive Therapy in Mania

1994 • 82 citations

Differential Efficacy of Olanzapine and Lithium in Preventing Manic or Mixed Recurrence in Patients With Bipolar I Disorder Based on Number of Previous Manic or Mixed Episodes

2006 • 81 citations

Efficacy and safety of aripiprazole in subpopulations with acute manic or mixed episodes of bipolar I disorder

2007 • 80 citations

Meta-analysis of placebo-controlled trials with mirtazapine using the core items of the Hamilton Depression Scale as evidence of a pure antidepressive effect in the short-term treatment of major depression

2001 • 80 citations

Repetitive transcranial magnetic stimulation as an add-on therapy in the treatment of mania: a case series of eight patients

2004 • 80 citations

AACAP OFFICIAL ACTION: Practice Parameters for the Psychiatric Assessment of Children and Adolescents

1995 • 79 citations

Recurrent Affective Syndromes in Bipolar and Unipolar Mood Disorders at Follow-Up

1995 • 79 citations

Bipolar Disorder: It's All in Your Mind? The Neuropsychological Profile of a Biological Disorder

2004 • 78 citations

A randomized, placebo- and active-controlled study of paliperidone extended-release as maintenance treatment in patients with bipolar I disorder after an acute manic or mixed episode

2012 • 78 citations

Short‐term fluoxetine monotherapy for bipolar type II or bipolar NOS major depression – low manic switch rate

2004 • 78 citations

New Directions in Affective Disorders

1989 • 77 citations

Texas Medication Algorithm Project

2001 • 77 citations

Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: A randomized, placebo-controlled study

2010 • 77 citations

Efficacy of Quetiapine Monotherapy for the Treatment of Depressive Episodes in Bipolar I Disorder

2008 • 76 citations

A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms.

1993 • 76 citations

A brief dyadic group based psychoeducation program improves relapse rates in recently remitted bipolar disorder: A pilot randomised controlled trial

2009 • 76 citations

Olanzapine plus carbamazepinev.carbamazepine alone in treating manic episodes

2008 • 76 citations

Impact of Antidepressant Continuation After Acute Positive or Partial Treatment Response for Bipolar Depression

2009 • 76 citations

Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients

2008 • 75 citations

Episode sequence in bipolar disorder and response to lithium treatment

1991 • 75 citations

Olanzapine versus lithium in the acute treatment of bipolar mania: A double-blind, randomized, controlled trial

2007 • 75 citations

Comparison of Rapid-Cycling and Non–Rapid-Cycling Bipolar I Manic Patients During Treatment With Olanzapine

2004 • 75 citations

Fluoxetine monotherapy of bipolar type II and bipolar NOS major depression: a double-blind, placebo-substitution, continuation study

2005 • 75 citations

The Maudsley Bipolar Disorder Project

2005 • 74 citations

Ziprasidone in the treatment of acute mania: a 12-week, placebo-controlled, haloperidol-referenced study

2008 • 74 citations

A double blind, randomized, placebo-controlled trial of quetiapine as an add-on therapy to lithium or divalproex for the treatment of bipolar mania

2007 • 74 citations

Extended-Release Carbamazepine Capsules as Monotherapy in Bipolar Disorder

2006 • 73 citations

A case series on the hypothesized connection between dementia and bipolar spectrum disorders: Bipolar type VI?

2007 • 73 citations

Inositol augmentation of lithium or valproate for bipolar depression

2006 • 73 citations

Treatment of bipolar disorder: a complex treatment for a multi-faceted disorder

2007 • 72 citations

Zur Nosologie endogener Depressionen

1968 • 72 citations

Prediction and prevention of suicide in patients with unipolar depression and anxiety

2007 • 71 citations

A randomized, double‐blind, placebo‐controlled clinical trial of acamprosate in alcohol‐dependent individuals with bipolar disorder: a preliminary report

2012 • 71 citations

Olanzapine/fluoxetine combination vs. lamotrigine in the 6-month treatment of bipolar I depression

2008 • 71 citations

Adjunctive Topiramate Therapy in Patients Receiving a Mood Stabilizer for Bipolar I Disorder

2006 • 71 citations

Verapamil for the Treatment of Acute Mania: A Double-Blind, Placebo-Controlled Trial

1998 • 69 citations

Quetiapine for the treatment of bipolar II depression: Analysis of data from two randomized, double-blind, placebo-controlled studies

2008 • 69 citations

Olanzapine in the acute treatment of bipolar I disorder with a history of rapid cycling

2002 • 68 citations

Prescription Patterns of Psychotropic Medications in Elderly Compared With Younger Participants Who Achieved a “Recovered” Status in the Systematic Treatment Enhancement Program for Bipolar Disorder

2008 • 68 citations

Do Atypical Antipsychotics Effectively Treat Co-Occurring Bipolar Disorder and Stimulant Dependence?

2008 • 67 citations

The Use of Placebo in Clinical Trials on Bipolar Disorder: A New Approach for an Old Debate

2004 • 67 citations

Randomized, placebo-controlled trial of risperidone for acute treatment of bipolar anxiety

2008 • 67 citations

Placebo-Controlled Adjunctive Trial of Pramipexole in Patients With Bipolar Disorder

2011 • 66 citations

The Efficacy of Cognitive-Behavioral Therapy in Bipolar Disorder

2009 • 66 citations

A randomized, placebo-controlled study of adjunctive ramelteon in ambulatory bipolar I disorder with manic symptoms and sleep disturbance

2010 • 65 citations

The comparative prophylactic efficacy of lithium and carbamazepine in patients with bipolar I disorder

1999 • 65 citations

Acute Dysphoric Mania: Treatment Response to Olanzapine Versus Placebo

2003 • 65 citations

Evaluation of the efficacy and safety of paliperidone extended-release in the treatment of acute mania: A randomized, double-blind, dose-response study

2010 • 65 citations

Aripiprazole in combination with lamotrigine for the long‐term treatment of patients with bipolar I disorder (manic or mixed): a randomized, multicenter, double‐blind study (CN138‐392)

2012 • 64 citations

Number Needed to Treat to Harm for Discontinuation Due to Adverse Events in the Treatment of Bipolar Depression, Major Depressive Disorder, and Generalized Anxiety Disorder With Atypical Antipsychotics

2010 • 64 citations

The comparative efficacy of carbamazepine low and high serum level and lithium carbonate in the prophylaxis of affective disorders

1993 • 64 citations

Trends in pharmacotherapy of Schizoaffective and bipolar affective disorders: a 5-year naturalistic study

1996 • 64 citations

Olanzapine Versus Placebo in Acute Mania

2003 • 64 citations

Texas Medication Algorithm Project: development and feasibility testing of a treatment algorithm for patients with bipolar disorder.

2001 • 62 citations

Olanzapine-Divalproex Combination Versus Divalproex Monotherapy in the Treatment of Bipolar Mixed Episodes

2009 • 62 citations

Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials

2011 • 62 citations

Bipolar I and II disorder residual symptoms: Oxcarbazepine and carbamazepine as add-on treatment to lithium in a double-blind, randomized trial

2008 • 62 citations

The BALANCE trial – Authors' reply

2010 • 62 citations

Switching, Induction of Rapid Cycling, and Increased Suicidality With Antidepressants in Bipolar Patients: Fact or Overinterpretation?

2008 • 62 citations

Risk and Protective Factors in the Development of Psychopathology

1995 • 61 citations

Latest maintenance data on lamotrigine in bipolar disorder

2003 • 61 citations

Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double‐blind, randomized, placebo‐controlled trial

2012 • 61 citations

Recurrence in Bipolar I Disorder: A Post Hoc Analysis Excluding Relapses in Two Double-blind Maintenance Studies

2006 • 61 citations

Effects of olanzapine alone and olanzapine/fluoxetine combination on health-related quality of life in patients with bipolar depression: Secondary analyses of a double-blind, placebo-controlled, randomized clinical trial

2004 • 61 citations

Incidence and Time Course of Subsyndromal Symptoms in Patients With Bipolar I Disorder

2006 • 60 citations

The comparative prophylactic efficacy of lithium and carbamazepine in patients with bipolar I disorder

1999 • 60 citations

Are antidepressants less effective in the acute treatment of bipolar I compared to unipolar depression?

2001 • 60 citations

Safety and Tolerability of Lamotrigine

2011 • 60 citations

Olanzapine/Fluoxetine Combination for the Treatment of Mixed Depression in Bipolar I Disorder

2009 • 60 citations

Acute Efficacy of Divalproex Sodium Versus Placebo in Mood Stabilizer–Naive Bipolar I or II Depression

2010 • 59 citations

Clinical value of early partial symptomatic improvement in the prediction of response and remission during short-term treatment trials in 3369 subjects with bipolar I or II depression

2010 • 59 citations

The lithiumeter: a measured approach

2011 • 59 citations

A double‐blind study of L‐sulpiride versus amitriptyline in lithium‐maintained bipolar depressives

1993 • 59 citations

Practice Parameters for the Assessment and Treatment of Children and Adolescents With Bipolar Disorder

1997 • 59 citations

Lithium versus carbamazepine in the maintenance treatment of bipolar II disorder and bipolar disorder not otherwise specified

1999 • 59 citations

Pharmacotherapy for the Treatment of Acute Bipolar II Depression

2010 • 58 citations

Double‐blind comparative clinical trial of pimozide and chlorpromazine in mania

1981 • 58 citations

Double‐blind randomized controlled study comparing short‐term efficacy of bifrontal and bitemporal electroconvulsive therapy in acute mania

2008 • 58 citations

International therapeutic guidelines for bipolar disorder

2007 • 57 citations

Effects of Prior Authorization on Medication Discontinuation Among Medicaid Beneficiaries With Bipolar Disorder

2009 • 57 citations

Pharmacological interventions for the prevention of relapse in bipolar disorder: a systematic review of controlled trials

2008 • 57 citations

Lithium compared to valproic acid and carbamazepine in the treatment of mania: a statistical meta-analysis

1996 • 57 citations

Lithium combined with carbamazepine or haloperidol in the treatment of mania.

1995 • 57 citations

Zur Nosologie endogener Depressionen: Vergleich der Ergebnisse zweier Untersuchungen

1968 • 57 citations

Lithium versus carbamazepine in the maintenance treatment of bipolar II disorder and bipolar disorder not otherwise specified

1999 • 57 citations

Analyses of Treatment-Emergent Mania With Olanzapine/Fluoxetine Combination in the Treatment of Bipolar Depression

2005 • 57 citations

I Know This Much Is True

2000 • 56 citations

Atypical antipsychotics in bipolar depression: Neurobiological basis and clinical implications

2006 • 56 citations

Abrupt lithium discontinuation in manic‐depressive patients

1982 • 56 citations

Efficacy and acceptability of mood stabilisers in the treatment of acute bipolar depression: systematic review

2010 • 56 citations

The Maudsley bipolar disorder project. A survey of psychotropic prescribing patterns in bipolar I disorder

2002 • 55 citations

Carbamazepine Compared to Haloperidol in Acute Mania

1989 • 55 citations

The sales of antidepressants and suicide rates in Norway and its counties 1980–2004

2007 • 55 citations

Response and remission rates in Chinese patients with bipolar mania treated for 4 weeks with either quetiapine or lithium: a randomized and double-blind study

2007 • 54 citations

Relationship of Mania Symptomatology to Maintenance Treatment Response with Divalproex, Lithium, or Placebo

2005 • 54 citations

Prophylactic effect of phenytoin in bipolar disorder: a controlled study

2003 • 53 citations

Early findings from a pharmacokinetically designed double-blind and placebo-controlled study of lithium for adolescents comorbid with bipolar and substance dependency disorders

1992 • 53 citations

Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double‐blind randomized controlled trial

2009 • 52 citations

Prophylactic efficacy of maprotiline on unipolar depression relapse.

1991 • 52 citations

An update of evidence-based treatment of bipolar depression: where do we stand?

2009 • 52 citations

Long-term outcome of bipolar depressed patients receiving lamotrigine as add-on to lithium with the possibility of the addition of paroxetine in nonresponders: a randomized, placebo-controlled trial with a novel design

2011 • 52 citations

Level of response and safety of pharmacological monotherapy in the treatment of acute bipolar I disorder phases: a systematic review and meta-analysis

2010 • 52 citations

Selecting effective long-term treatment for bipolar patients: monotherapy and combinations.

2003 • 52 citations

A double-blind study comparing idazoxan and bupropion in bipolar depressed patients

1999 • 52 citations

Acute Mania: Haloperidol Dose and Augmentation With Lithium or Lorazepam

1999 • 52 citations

Spotlight on Lamotrigine in Bipolar Disorder1

2004 • 51 citations

International Consensus Group on the Evidence-Based Pharmacologic Treatment of Bipolar I and II Depression

2008 • 51 citations

Reduced Suicidal Ideation in Bipolar I Disorder Mixed-Episode Patients in a Placebo-Controlled Trial of Olanzapine Combined With Lithium or Divalproex

2006 • 50 citations

Aripiprazole monotherapy in patients with rapid-cycling bipolar I disorder: an analysis from a long-term, double-blind, placebo-controlled study

2008 • 49 citations

A Randomized Controlled Trial of Cognitive Behavioral Group Therapy for Bipolar Disorder

2011 • 49 citations

Olanzapine in the long-term treatment of bipolar disorder: A systematic review and meta-analysis

2009 • 49 citations

Maintenance of response following stabilization of mixed index episodes with olanzapine monotherapy in a randomized, double-blind, placebo-controlled study of bipolar 1 disorder

2008 • 49 citations

Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner: an fMRI study

2005 • 49 citations

Meta-analysis: Fact or fiction? How to interpret meta-analyses

2011 • 49 citations

Number needed to treat analyses of drugs used for maintenance treatment of bipolar disorder

2010 • 49 citations

The Ham D₆ is more homogenous and as sensitive as the Ham D₁₇

2007 • 49 citations

Levetiracetam in the Management of Bipolar Depression

2010 • 48 citations

Risperidone alone or in combination for acute mania

2006 • 48 citations

Medication use patterns and 2‐year outcome in first‐admission bipolar disorder with psychotic features

2004 • 48 citations

Aripiprazole monotherapy in the treatment of bipolar disorder: A meta-analysis

2010 • 47 citations

Australian and New Zealand clinical practice guidelines for the treatment of bipolar disorder

2004 • 47 citations

General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry

2011 • 47 citations

Receptor targets for antidepressant therapy in bipolar disorder: An overview

2011 • 46 citations

A comparison of two fixed doses of aripiprazole with placebo in acutely relapsed, hospitalized patients with bipolar disorder I (manic or mixed) in subpopulations (CN138-007)

2010 • 46 citations

Validating Kraepelin's two types of depressive mixed states: ‘depression with flight of ideas’ and ‘excited depression’

2004 • 46 citations

Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double‐blind, controlled, add‐on clinical trial

2010 • 46 citations

Aripiprazole in the Maintenance Treatment of Bipolar Disorder: A Critical Review of the Evidence and Its Dissemination into the Scientific Literature

2011 • 45 citations

The effectiveness of cognitive behavioral group therapy in treating bipolar disorder: a randomized controlled study

2011 • 45 citations

Symptomatic Remission in Patients With Bipolar Mania

2005 • 45 citations

Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate.

2004 • 44 citations

Risperidone long-acting injectable (Risperdal Consta^®) for maintenance treatment in patients with bipolar disorder

2010 • 44 citations

Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)

2009 • 44 citations

Oxcarbazepine in the maintenance treatment of bipolar disorder

2008 • 43 citations

Olanzapine alone or in combination for acute mania

2003 • 43 citations

Genetic features of antidepressant induced mania and hypo-mania in bipolar disorder

2004 • 43 citations

Lithium in bipolar and other affective disorders: prescribing practice in the UK

2010 • 43 citations

ECNP Consensus Meeting March 2000 Nice

2001 • 42 citations

Neuroleptics in Acute Mania: A Pharmacoepidemiologic Study

1996 • 42 citations

Aripiprazole as adjunct to a mood stabilizer and citalopram in bipolar depression: a randomized placebo‐controlled pilot study

2010 • 42 citations

Rapid versus non-rapid cycling as a predictor of response to olanzapine and divalproex sodium for bipolar mania and maintenance of remission: Post hoc analyses of 47-week data

2005 • 42 citations

Extended-Release Quetiapine as Monotherapy for the Treatment of Adults With Acute Mania: A Randomized, Double-Blind, 3-Week Trial

2011 • 42 citations

Inter-episodic morbidity and drop-out under carbamazepine and lithium in the maintenance treatment of bipolar disorder

2002 • 41 citations

Lithium treatment of manic-depressive disorder. Dosage and control.

1967 • 40 citations

Refractoriness in Bipolar Disorder: Definitions and Evidence‐Based Treatment

2011 • 40 citations

Depressive relapse during lithium treatment associated with increased serum thyroid‐stimulating hormone: results from two placebo‐controlled bipolar I maintenance studies

2009 • 40 citations

Efficacy of ziprasidone in dysphoric mania: Pooled analysis of two double-blind studies

2009 • 39 citations

Mental and Physical Health of Homeless Persons Who Use Emergency Shelters in Vancouver

1993 • 39 citations

European College of Neuropsychopharmacology

1986 • 39 citations

Number needed to treat and time to response/remission for quetiapine monotherapy efficacy in acute bipolar depression: evidence from a large, randomized, placebo-controlled study

2007 • 38 citations

Quetiapine XR efficacy and tolerability as monotherapy and as adjunctive treatment to conventional antidepressants in the acute and maintenance treatment of major depressive disorder: a review of registration trials

2009 • 38 citations

Experimental Withdrawal of Lithium in Recovered Manic-Depressive Patients: A Report of Five Cases

1971 • 37 citations

Cognitive-Behavioral Therapy for Depression in Bipolar Disorder: A Meta-Analysis

2010 • 37 citations

Lithium Withdrawal Triggers Psychosis

1982 • 37 citations

Efficacy and safety of two treatment algorithms in bipolar depression consisting of a combination of lithium, lamotrigine or placebo and paroxetine

2010 • 37 citations

Notes on mental disorders in Pharaonic Egypt

2000 • 37 citations

Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6‐month, randomized, placebo‐controlled, double‐blind maintenance trial

2011 • 36 citations

Is Anticonvulsant Treatment of Mania a Class Effect? Data from Randomized Clinical Trials

2009 • 34 citations

Onset of antidepressant effect of olanzapine and olanzapine/fluoxetine combination in bipolar depression

2007 • 34 citations

LITHIUM PROPHYLAXIS IN AFFECTIVE DISORDERS

1972 • 33 citations

Strategies for preventing the recurrence of bipolar disorder.

2004 • 33 citations

Suicidal Ideation and Pharmacotherapy Among STEP-BD Patients

2005 • 32 citations

Is treatment-associated hypomania rare with duloxetine: Secondary analysis of controlled trials in non-bipolar depression

2005 • 32 citations

Randomized, Double-Blind, Placebo-Controlled Study of Divalproex Extended Release Loading Monotherapy in Ambulatory Bipolar Spectrum Disorder Patients With Moderate-to-Severe Hypomania or Mild Mania

2010 • 31 citations

Comparative efficacy and acceptability of mood stabilizer and second generation antipsychotic monotherapy for acute mania — A systematic review and meta-analysis

2010 • 31 citations

Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study.

2010 • 31 citations

Algorithms for the treatment of bipolar manic-depressive illness.

1995 • 31 citations

International Consensus Group on Depression Prevention in Bipolar Disorder

2011 • 30 citations

A Randomized, Placebo-Controlled, Multicenter Study of Divalproex Sodium Extended-Release in the Acute Treatment of Mania

2010 • 30 citations

Lamotrigine: when and where does it act in affective disorders? A systematic review

2010 • 29 citations

Rapid antipsychotic response with ziprasidone predicts subsequent acute manic/mixed episode remission

2009 • 29 citations

Revised Korean medication algorithm for bipolar disorder

2008 • 29 citations

Lithium Treatment of Manic-Depressive Disorder

1967 • 28 citations

Handbook of Bipolar Disorder

2005 • 28 citations

Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: A pilot study

2009 • 28 citations

NICE issues new guidance to improve the treatment of bipolar disorder

2006 • 28 citations

Thrombocytopenia associated with carbamazepine: a case series.

1991 • 28 citations

Revisiting the effectiveness of standard antidepressants in bipolar disorder: are monoamine oxidase inhibitors superior?

2009 • 28 citations

Efficacy and safety of olanzapine in the treatment of Japanese patients with bipolar I disorder in a current manic or mixed episode: A randomized, double-blind, placebo- and haloperidol-controlled study

2011 • 27 citations

The study protocol of the Norwegian randomized controlled trial of electroconvulsive therapy in treatment resistant depression in bipolar disorder

2010 • 27 citations

Placebo-controlled study of quetiapine monotherapy in ambulatory bipolar spectrum disorder with moderate-to-severe hypomania or mild mania

2009 • 27 citations

The Pharmacological Treatment of Bipolar Affective Disorder: Practice Is Improving but Could Still be Better

2003 • 26 citations

Olanzapine vs. lithium in management of acute mania

2009 • 26 citations

Role of aripiprazole in treating mood disorders

2006 • 25 citations

Treatment of bipolar depressive mood disorders: Algorithms for pharmacotherapy

1997 • 25 citations

Changes in outpatient lithium treatment in the Netherlands during 1996–2005

2008 • 25 citations

Brief Reports: Patterns of Psychotropic Medication Use by Race Among Veterans With Bipolar Disorder

2006 • 24 citations

Long-term maintenance drug therapy in recurrent affective illness: current status and issues.

1977 • 24 citations

Abstracts

2010 • 23 citations

Quetiapine Monotherapy as Treatment for Anxiety Symptoms in Patients With Bipolar Depression

2009 • 22 citations

Quality of Reporting of Randomized Controlled Trials of Pharmacologic Treatment of Bipolar Disorders

2011 • 22 citations

Service utilization and costs of olanzapine versus divalproex treatment for acute mania: results from a randomized, 47-week clinical trial

2005 • 22 citations

Use of lithium in the adult populations of Denmark, Norway and Sweden

2009 • 22 citations

Trends in lithium prescription in Spain from 1985 to 2003

2006 • 22 citations

Pharmacotherapy patterns in the treatment of bipolar disorder

2002 • 22 citations

Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis

2009 • 21 citations

Prescribing trends of antidepressants in bipolar depression.

1995 • 21 citations

Comparison of paroxetine and amitriptyline as adjunct to lithium maintenance therapy in bipolar depression: A reanalysis of a randomized, double-blind study

2010 • 21 citations

Indian study sparks debate on the use of placebo in psychiatry trials

2006 • 20 citations

Class effect of pharmacotherapy in bipolar disorder: fact or misbelief?

2011 • 20 citations

Lithium Treatment in Aarhus. 1. Prevalence

1989 • 19 citations

Book review

1971 • 19 citations

Improvement of positive and negative syndrome scale cognitive score associated with olanzapine treatment of acute mania

2004 • 18 citations

Guideline Watch (November 2005): Practice Guideline for the Treatment of Patients with Bipolar Disorder, 2nd Edition

2007 • 18 citations

Living with bipolar disorder

2004 • 18 citations

Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: Long-term changes in weight and metabolic profiles

2011 • 17 citations

Medication patterns and costs associated with olanzapine and other atypical antipsychotics in the treatment of bipolar disorder

2007 • 16 citations

NIMH report. Five-center study clarifies use of lithium, imipramine for recurrent affective disorders.

1984 • 16 citations

Early symptom change and prediction of subsequent remission with olanzapine augmentation in divalproex-resistant bipolar mixed episodes

2010 • 16 citations

The impact of response to previous mood stabilizer therapy on response to olanzapine versus placebo for acute mania

2002 • 16 citations

Ethics of a placebo-controlled trial in severe mania

2006 • 16 citations

Effectiveness and safety of adjunctive antidepressants in the treatment of bipolar depression: a review.

2008 • 15 citations

III. A DOUBLE BLIND STUDY OF THE PROPHYLACTIC EFFECT OF LITHIUM IN MANIC‐DEPRESSIVE DISEASE

1977 • 14 citations

[Has drug treatment of manic disorders changed in clinical routine practice? Retrospective analysis of treatment modalities and results in a university psychiatric clinic].

1996 • 14 citations

Psychopharmacological Treatment Status in Outpatients with Bipolar Disorder: A Clinical Survey in Germany

2010 • 13 citations

Guidelines for treatment of bipolar disorder

2000 • 12 citations

Mania From Dose-Related Ziprasidone Augmentation of an SSRI

2003 • 12 citations

Ziprasidone HCl capsules for the adjunctive maintenance treatment of bipolar disorder in adults

2010 • 12 citations

Naturalistic evaluation of inpatient treatment of mania in a private Brazilian psychiatric hospital

2003 • 12 citations

Questionnaire survey on the prescribing practice of Japanese psychiatrists for mood disorders.

1999 • 12 citations

Study design and patient characteristics and outcome in acute mania clinical trials

2011 • 12 citations

International Psychopharmacology Algorithm Project: Algorithms in Psychopharmacology

1997 • 11 citations

Clinical Practice Guidelines: The Massachusetts Experience in Psychiatry

1999 • 11 citations

P.2.e.037 The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial

2009 • 10 citations

Five-Center Study Clarifies Use of Lithium, Imipramine for Recurrent Affective Disorders

1984 • 10 citations

Deramciclane in GAD

2001 • 8 citations

Praxis der stationären Akutbehandlung von Manien

1994 • 7 citations

Use of Carbamazepine in Affective Illness

1989 • 6 citations

Typical neuroleptics vs. atypical antipsychotics in the treatment of acute mania in a natural setting

2005 • 6 citations

Clinical Practice Guidelines: The Massachusetts Experience in Psychiatry

1999 • 6 citations

Méta-analyses ou méga-essais: un même niveau de preuves?

2007 • 5 citations

[Pharmacotherapeutic trends at the beginning of the millennium in Hungary: pharmacotherapy of bipolar patients. Part II].

2004 • 3 citations

P.3.c.005 Aripiprazole monotherapy in acute bipolar I mania: a randomized, placebo- & lithium-controlled study (CN138–135)

2007 • 2 citations

Deleted Work

1955 • 0 citations