Small Peptide Mimics of Nerve Growth Factor Bind TrkA Receptors and Affect Biological Responses

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Solid phase peptide synthesis utilizing 9‐fluorenylmethoxycarbonyl amino acids

1990 • 2,426 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

β-Hairpin families in globular proteins

1985 • 533 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

Conformation of β-hairpins in protein structures

1989 • 476 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.

1992 • 368 citations

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

1994 • 353 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors.

1994 • 313 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.

1991 • 255 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Design and Synthesis of a Mimetic from an Antibody Complementarity-Determining Region

1991 • 163 citations

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

1993 • 151 citations

Nerve Growth Factor

1977 • 113 citations

Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF.

1986 • 112 citations

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.

1991 • 111 citations

Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope.

1986 • 110 citations

Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants

1993 • 88 citations

Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.

1992 • 65 citations

Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors.

1993 • 63 citations

The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trkA

1992 • 58 citations

The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.

1990 • 57 citations

Immunological relationships of NGF, BDNF, and NT-3: recognition and functional inhibition by antibodies to NGF

1993 • 54 citations

Characterization of antibodies to synthetic nerve growth factor (NGF) and ProNGF peptides

1989 • 29 citations

Immunological determinants of nerve growth factor involved in p140^trk (Trk) receptor binding

1994 • 23 citations