Tamoxifen in the Treatment of Breast Cancer

The pharmacology and clinical uses of tamoxifen

1984 • 873 citations

The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.

1976 • 820 citations

Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen*

1978 • 407 citations

Tamoxifen in advanced breast cancer

1978 • 343 citations

Randomized Clinical Trial of Diethylstilbestrol versus Tamoxifen in Postmenopausal Women with Advanced Breast Cancer

1981 • 334 citations

Contrasting Endocrine Activities of cis and trans Isomers in a Series of Substituted Triphenylethylenes

1966 • 315 citations

CONTROLLED TRIAL OF TAMOXIFEN AS SINGLE ADJUVANT AGENT IN MANAGEMENT OF EARLY BREAST CANCER

1985 • 291 citations

Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial.

1986 • 215 citations

Tamoxifen as initial sole treatment of localised breast cancer in elderly women: a pilot study.

1982 • 184 citations

Randomized trial of bilateral oophorectomy versus tamoxifen in premenopausal women with metastatic breast cancer.

1986 • 175 citations

Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells.

1987 • 172 citations

Tamoxifen (Antiestrogen) Therapy in Advanced Breast Cancer

1977 • 169 citations

A randomized comparison of tamoxifen with surgical oophorectomy in premenopausal patients with advanced breast cancer.

1986 • 160 citations

Tamoxifen versus aminoglutethimide in advanced breast carcinoma: a randomized cross-over trial.

1981 • 155 citations

Experimental and clinical results with intraperitoneal cisplatin.

1985 • 150 citations

Tamoxifen Flare in Advanced Breast Cancer

1978 • 142 citations

Estrogen-Like Action of Tamoxifen on Vaginal Epithelium in Breast Cancer Patients

1981 • 138 citations

Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance

1982 • 133 citations

Evaluation of Tamoxifen Doses With and Without Fluoxymesterone in Advanced Breast Cancer

1983 • 129 citations

Primary treatment of breast cancer in elderly women with Tamoxifen.

1983 • 118 citations

Role and mechanism of action of tamoxifen in premenopausal women with metastatic breast carcinoma.

1986 • 113 citations

Tamoxifen therapy in premenopausal patients with metastatic breast cancer.

1980 • 107 citations

Combination Chemotherapy Compared to Tamoxifen as Initial Therapy for Stage IV Breast Cancer in Elderly Women

1986 • 105 citations

Hormonal Therapy of Breast Cancer: New Approaches and Concepts

1978 • 102 citations

Long-term tamoxifen adjuvant therapy in node-positive breast cancer: A metabolic and pilot clinical study

1984 • 99 citations

Determination and pharmacology of a new hydroxylated metabolite of tamoxifen observed in patient sera during therapy for advanced breast cancer.

1983 • 96 citations

Effects of biologically active metabolites of tamoxifen on the proliferation kinetics of MCF-7 human breast cancer cells in vitro.

1983 • 95 citations

In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer

1977 • 93 citations

Antiestrogen-induced remissions in premenopausal women with stage IV breast cancer: effects on ovarian function.

1980 • 92 citations

The effectiveness of long term tamoxifen treatment in a laboratory model for adjuvant hormone therapy of breast cancer.

1979 • 89 citations

Current status of Milan adjuvant chemotherapy trials for node-positive and node-negative breast cancer.

1986 • 87 citations

Antiestrogens in the treatment of breast cancer

1976 • 86 citations

Tamoxifen versus aminoglutethimide versus combined tamoxifen and aminoglutethimide in the treatment of advanced breast carcinoma.

1982 • 86 citations

Tamoxifen as primary treatment of breast cancer in elderly or frail patients: a practical management.

1985 • 85 citations

Oral high-dose medroxyprogesterone acetate versus tamoxifen. A randomized crossover trial in postmenopausal patients with advanced breast cancer.

1986 • 74 citations

Concurrent or sequential use of cytotoxic chemotherapy and hormone treatment in advanced breast cancer: report of the Swiss Group for Clinical Cancer Research.

1983 • 71 citations

Tamoxifen-induced hypercalcemia in breast cancer

1981 • 67 citations

Adjuvant treatment for early breast cancer: the Ludwig breast cancer studies.

1986 • 66 citations

The Christie Hospital Tamoxifen (Nolvadex) adjuvant trial for operable breast carcinoma - 7-yr results

1985 • 62 citations

Efforts to combine endocrine and chemotherapy in the management of breast cancer: Do two and two equal three?

1983 • 62 citations

Tamoxifen versus placebo: double-blind adjuvant trial in elderly women with stage II breast cancer.

1986 • 56 citations

Current overview of EORTC clinical trials with tamoxifen.

1976 • 55 citations

Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer.

1981 • 53 citations

Therapeutic effect of tamoxifen versus tamoxifen combined with medroxyprogesterone acetate in advanced breast cancer in postmenopausal women.

1979 • 52 citations

Adjuvant tamoxifen in postmenopausal breast cancer: Preliminary results of a randomized trial

1986 • 46 citations

A randomized trial of aminoglutethimide versus tamoxifen in metastatic breast cancer.

1982 • 45 citations

Tamoxifen (Nolvadex) for premenopausal patients with advanced breast cancer

1984 • 41 citations

Megestrol acetate v tamoxifen in advanced breast cancer: correlation of hormone receptors and response.

1986 • 40 citations

Antiestrogen treatment of breast cancer: an overview.

1982 • 37 citations

Tamoxifen and oophorectomy in the treatment of recurrent breast cancer: a Southwest Oncology Group Study.

1982 • 36 citations

Methotrexate and 5-fluorouracil following tamoxifen and premarin in advanced breast cancer.

1983 • 34 citations

Tamoxifen. Use in treatment of metastatic breast cancer refractory to combination chemotherapy

1979 • 34 citations

The value of magnetic resonance imaging in assessment of carcinoma of the cervix and its response to radiotherapy

1992 • 28 citations

Chemotherapy Versus Combination of Chemotherapy and Endocrine Therapy in Advanced Breast Cancer

1983 • 28 citations

Adjuvant tamoxifen in postmenopausal high-risk breast cancer patients: present status of Danish Breast Cancer Cooperative Group trials.

1986 • 28 citations

Antiestrogen-cytotoxic chemotherapy and bacillus Calmette-Guerin vaccination in stage II breast cancer: seventy-two-month follow-up.

1984 • 27 citations

Tamoxifen therapy in premenopausal women with metastatic breast cancer.

1985 • 27 citations

The tamoxifen trial - a double-blind comparison with stilboestrol in postmenopausal women with advanced breast cancer.

1980 • 26 citations

Chemoendocrine therapy vs chemotherapy alone for advanced breast cancer in postmenopausal women: Preliminary report of a randomized study

1983 • 26 citations

Randomized clinical trial of tamoxifen plus sequential CMF chemotherapy versus tamoxifen alone in postmenopausal women with advanced breast cancer

1981 • 25 citations

Comparison of tamoxifen and hypophysectomy in breast cancer treatment

1980 • 23 citations

Tamoxifen therapy of metastatic breast cancer.

1987 • 21 citations

Combined cytotoxic and endocrine therapy in postmenopausal patients with advanced breast cancer

1985 • 19 citations

Removable subcuticular skin suture in acute appendicitis: a prospective comparative clinical trial.

1982 • 19 citations

Tamoxifen (nolvadex) versus adrenalectomy in metastatic breast cancer

1984 • 18 citations

Sequential treatment of metastatic breast cancer with tamoxifen after megestrol acetate therapy and vice versa (a retrospective study)

1985 • 10 citations

Response of advanced breast cancer to total endocrine ablation after exacerbation on tamoxifen: Results in seven patients and possible mechanism of action

1987 • 7 citations

Tamoxifen Therapy for Premenopausal and Postmenopausal Japanese Females with Advanced Breast Cancer

1982 • 7 citations

A clinical assessment of loading dose tamoxifen for advanced breast carcinoma.

1984 • 6 citations

Combined therapy in advanced breast cancer

1985 • 6 citations