Acute Cardiovascular Effects of OPC-18790 in Patients With Congestive Heart Failure

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

1991 • 2,186 citations

Instantaneous Pressure-Volume Relationships and Their Ratio in the Excised, Supported Canine Left Ventricle

1974 • 1,307 citations

Continuous measurement of left ventricular volume in animals and humans by conductance catheter.

1984 • 904 citations

Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work.

1985 • 873 citations

Left ventricular interaction with arterial load studied in isolated canine ventricle

1983 • 788 citations

Effective arterial elastance as index of arterial vascular load in humans.

1992 • 773 citations

Left ventricular volume and mass from single-plane cineangiocardiogram. A comparison of anteroposterior and right anterior oblique methods

1970 • 641 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships.

1987 • 487 citations

Effects of Vesnarinone on Morbidity and Mortality in Patients with Heart Failure

1993 • 482 citations

Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle.

1985 • 452 citations

Evaluation of a New Bipyridine Inotropic Agent — Milrinone — in Patients with Severe Congestive Heart Failure

1983 • 340 citations

Ventriculoarterial coupling in normal and failing heart in humans.

1989 • 337 citations

Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting.

1982 • 278 citations

Influence of contractile state on curvilinearity of in situ end-systolic pressure-volume relations.

1989 • 260 citations

Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure. Dose-response relationships and comparison to nitroprusside.

1985 • 258 citations

Use of a conductance (volume) catheter and transient inferior vena caval occlusion for rapid determination of pressure‐volume relationships in man

1988 • 224 citations

Hemodynamic changes mimicking a vasodilator drug response in the absence of drug therapy after right heart catheterization in patients with chronic heart failure.

1985 • 185 citations

Left ventricular-arterial coupling relations in the normal human heart

1993 • 185 citations

Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading

1993 • 151 citations

Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants.

1993 • 142 citations

Influence of heart rate on left ventricular performance in conscious dogs.

1987 • 124 citations

Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart.

1987 • 89 citations

Relation between ventriculoarterial coupling and myocardial energetics in patients with idiopathic dilated cardiomyopathy

1994 • 87 citations

Ventricular systolic assessment in patients with dilated cardiomyopathy by preload-adjusted maximal power. Validation and noninvasive application.

1994 • 83 citations

Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives

1992 • 65 citations

Usefulness of OPC-8212, a quinolinone derivative, for chronic congestive heart failure in patients with ischemic heart disease or idiopathic dilated cardiomyopathy

1991 • 61 citations

Ventricular load optimization by unloading therapy in patients with heart failure

1991 • 59 citations

Inotropic effect of enoximone in patients with severe heart failure: Demonstration by left ventricular end-systolic pressure-volume analysis

1987 • 52 citations

Amrinone in Cardiac Surgical Patients With Left-Ventricular Dysfunction

1993 • 50 citations

Determinants of end-systolic pressure-volume relations during acute regional ischemia in situ.

1989 • 43 citations

Cardiovascular actions of OPC-18790: A novel positive inotropic agent with little chronotropic action

1992 • 32 citations

Hemodynamic dependence of myocardial oxygen consumption indexes

1990 • 29 citations

Determination of left ventricular volume using a conductance catheter in the diseased human heart

1992 • 24 citations

Comparison of single and biplane ventriculography for determination of left ventricular volume and ejection fraction

1992 • 22 citations

Long-term Oral Therapy of Congestive Heart Failure with Phosphodiesterase Inhibitors

1989 • 22 citations

Effects of a Novel Cardiotonic Agent (±)-6-[3-(3,4-Dimethoxybenzylamino)-2-Hydroxypropoxy]-2(1H)-Quinolinone (OPC-18790) on Contractile Force, Cyclic AMP Level, and Aequorin Light Transients in Dog Ventricular Myocardium

1994 • 22 citations

Positive inotropic and lusitropic effects of intravenous flosequinan in patients with heart failure

1992 • 18 citations

Effects of a novel inotropic agent (OPC-18790) on systolic and diastolic function in patients with severe heart failure

1994 • 17 citations

2(1H)-Quinolinones with cardiac stimulant activity. 3. Synthesis and biological properties of 6-imidazol-1-yl derivatives

1989 • 16 citations

Effects of OPC-18790, a New Positive Inotropic Agent, on Canine Ventricular Arrhythmias

1993 • 16 citations

Ventricular-load optimization by inotropic stimulation in patients with heart failure

1991 • 11 citations

Differential effects of OPC‐18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea‐pig isolated ischaemic heart

1995 • 11 citations

Voltage-dependent inhibition of the delayed outward potassium current by OPC-8490, a novel positive inotropic agent, in isolated atrial myocytes of guinea-pig heart

1990 • 9 citations

Pharmacokinetics and Pharmacodynamics of Intravenous OPC‐18790 in Humans: A Novel Nonglycosidic Inotropic Agent

1994 • 9 citations

Comparative hemodynamic effects of OPC-18790 and dobutamine in patients with advanced heart failure

1994 • 8 citations

Quinolinone derivatives in the management of congestive heart failure

1994 • 5 citations

Stereoselective high-performance liquid chromatographic assay for the determination of OPC-18790 enantiomers in human plasma and urine

1993 • 5 citations