Mechanistic advances in eukaryotic gene activation

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

DNA RECOGNITION BY PROTEINS WITH THE HELIX-TURN-HELIX MOTIF

1990 • 580 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

Zinc fingers and other metal-binding domains. Elements for interactions between macromolecules.

1990 • 509 citations

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID.

1990 • 501 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

Functional Domains and Upstream Activation Properties of Cloned Human TATA Binding Protein

1990 • 471 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1990 • 450 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives

1990 • 386 citations

A mediator required for activation of RNA polymerase II transcription in vitro

1991 • 383 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

Function of a yeast TATA element-binding protein in a mammalian transcription system

1988 • 364 citations

What determines the specificity of action of Drosophila homeodomain proteins?

1990 • 357 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)

1990 • 346 citations

Cloning of a Transcriptionally Active Human TATA Binding Factor

1990 • 332 citations

Sequence-Specific DNA Binding by a Short Peptide Dimer

1990 • 318 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

How different eukaryotic transcriptional activators can cooperate promiscuously

1990 • 261 citations

Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions

1989 • 256 citations

Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.

1990 • 255 citations

Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID

1990 • 254 citations

Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

1990 • 227 citations

Promoter specificity and modulation of RNA polymerase II transcription

1989 • 221 citations

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

1990 • 221 citations

DNA binding specificity of steroid receptors

1989 • 212 citations

An enhancer stimulates transcription in Trans when attached to the promoter via a protein bridge

1989 • 202 citations

Altered protein conformation on DNA binding by Fos and Jun

1990 • 193 citations

The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex.

1990 • 191 citations

Arabidopsis thaliana contains two genes for TFIID

1990 • 160 citations

GAL11P: A yeast mutation that potentiates the effect of weak GAL4-derived activators

1990 • 149 citations

A Potent GAL4 Derivative Activates Transcription at a Distance in Vitro

1990 • 148 citations

Transcription initiation complexes and upstream activation with RNA polymerase II lacking the C-terminal domain of the largest subunit.

1990 • 53 citations

The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro.

1990 • 44 citations

Synergistic activation of transcription by multiple binding sites for NF-κB even in absence of co-operative factor binding to DNA

1990 • 43 citations

Transcriptional activation by Sp1 as directed through TATA or initiator: specific requirement for mammalian transcription factor IID

1990 • 12 citations